This comprehensive book offers an in-depth overview of laboratory diagnoses for both inherited and acquired thrombophilias, illuminating the complex interplay between genetic and environmental factors that contribute to venous thromboembolism.
Beginning with foundational concepts in thrombophilia testing, the book systematically covers the diagnosis of key anticoagulant deficiencies, including protein C, protein S, protein Z, antithrombin, and plasminogen, as well as the critical evaluation of prothrombin G20210A and factor V Leiden mutations and other factors involved in thrombosis. It also addresses acquired thrombophilia, highlighting the significant impact of factors such as hyperhomocysteinemia and the influence of medications, lifestyle choices, and underlying health conditions on thrombosis risk.
Each chapter clarifies the principles behind various laboratory assays, detailing the preanalytical variables that can affect results and guiding the interpretation of findings. Real-world challenges in thrombophilia testing such as during pregnancy, the use of oral contraceptives, and monitoring anticoagulation therapy are specifically examined.
Written in a clear yet comprehensive style, this book is aimed at thrombosis specialists, hematologists, laboratory scientists, and students. It provides extensive knowledge, practical guidance, and evidence-based protocols for thrombophilia testing, ensuring accurate diagnosis and effective management of this life-threatening disorder.
1. An Overview of Laboratory Diagnosis of Thrombophilia.-
2. Laboratory
Diagnosis of Congenital Antithrombin Deficiency.-
3. Laboratory Diagnosis of
Congenital and Acquired Protein C Deficiencies and Assays for Circulating
Activated Protein C levels.-
4. Laboratory Diagnosis of Hereditary and
Acquired Protein S Deficiencies.-
5. Laboratory Diagnosis of Protein Z
Deficiency.-
6. Laboratory Diagnosis of Factor V Leiden.-
7. Laboratory
Diagnosis of Prothrombin G20210A Mutation.-
8. Laboratory Diagnosis of
Congenital and Acquired Hyper-homocysteinemia.-
9. Laboratory Diagnosis of
Congenital Plasminogen Deficiency.-
10. Laboratory Diagnosis of Congenital
Tissue Factor Pathway Inhibitor.-
11. Laboratory Diagnosis of Tissue
Plasminogen Activator Deficiency.-
12. Laboratory Diagnosis of Combined
Inherited/Genetic Thrombophilia.-
13. Laboratory Diagnosis of Inherited and
Acquired Factors Involved in Thrombosis.
Dr Akbar Dorgalaleh is a scientific researcher in the field of thrombosis and haemostasis who has (co-)authored over 120 publications. He is/was on the editorial board of several international journals, including Seminars in Thrombosis and Haemostasis, PLOS One, and Cellular and Molecular Anaesthesia. In addition, Dr Dorgalaleh is a current member of several international scientific societies or working groups, including the International Society on Thrombosis and Hemostasis (ISTH) Scientific Standardisation Committees (SSCs) on the Subcommittee on Factor XIII and Fibrinogen and the International Council for Standardisation in Haematology (ICSH). As editor of the Springer book Congenital Bleeding Disorders: Diagnosis and Management (2nd edition, 2023), he provides a comprehensive insight into congenital bleeding disorders such as Glanzmann thrombasthenia, Bernard-Soulier syndrome and Factor XIII deficiency, covering modern diagnostic and therapeutic advances. Mr Samadov is a medical laboratory professional with extensive experience in clinical diagnostics. He completed his education in medical laboratory science at the Mashhad University of Medical Sciences. Following his studies, he moved to Dushanbe, Tajikistan, where he has built a distinguished career in medical clinical laboratory work spanning over a decade. During his tenure in Dushanbe, Samadov developed extensive expertise in the practical aspects of laboratory medicine.
