Since the development of the first clinical MRI contrast agent, Gd(DTPA) (or Magnevist®) in the early 1980s, another three linear and three macrocyclic (eg. Gd(DOTA) (Dotarem®) have been introduced in the clinic and inspired a huge number of researchers worldwide to perform preclinical research to obtain contrast agents for many kinds of clinical applications, which are described in this book. The most current research has been assembled here and can be used by the scientific community to continue increasing the relevance of metal-containing molecules and nanomaterials for MRI-based diagnosis and thus increase the practical use of these systems.
- Presents the importance of metal-containing molecules and nanomaterials for MRI-based diagnosis and the practical use of these systems.
- Discusses the structure and dynamics of Ln-based contrast agents as well as computational studies related to these agents.
- Endorses and stimulates research in the vibrant field of biological inorganic chemistry.
- Reviews the most current research supporting the relevance of metal-containing molecules and nanomaterials for diagnosis and therapy.
- The authors are preeminent bioinorganic and medicinal inorganic chemists and review the most current research in this field.
The diagnostic application of MRI Contrast agents, both in the form of Gd3+ and transition metal complexes, like Mn at different oxidation states, as well as of nanomaterials, such as iron oxides, ferrites and Ln3+ salts, including their theranostic potential, is described in detail.
Chapter 1 Synthesis and Characterization of Ligands and Their Gd(III)
Complexes
Raphaėl Tripier, Maryline Beyler
Chapter 2 PARASHIFT Systems: Including 19F Effects
Peter Harvey
Chapter 3 Targeted MRI Contrast Agents
Alexander G. Sertage, Md. Sydul Islam, and Matthew J. Allen
Chapter 4 Responsive MRI Contrast Agents
Luke A. Marchetti, Manon Isaac, Célia S. Bonnet
Chapter 5 Mn-Based Small Complexes as MRI Contrast Agents
Zoltįn Garda, Sara Lacerda and Éva Tóth
Chapter 6 Other First-Row Transition Metal-Based Complexes as MRI Contrast
Agents
Janet R. Morrow and Jaclyn J. Raymond
Chapter 7 Lanthanide-based paramagnetic chemical exchange saturation transfer
(paraCEST) agents for MRI
A. Dean Sherry & Mark Woods
Chapter 8 LipoCEST and Similar Systems
Silvio Aime and Enzo Terreno
Chapter 9 Superparamagnetic Iron Oxide and Ferrite Nanoparticles for MRI
Thomas Vangijzegem, Levy Van Leuven, Dimitri Stanicki, Robert N. Muller,
Sophie Laurent
Chapter 10 Ln-based particles as MRI contrast agents
Joop A. Peters and Kristina Djanashvili
Chapter 11 Manganese and Iron Based Nanoparticles as MRI Contrast Agents
Fabio Carniato, Lorenzo Tei, and Carlos F,G. C. Geraldes
Chapter 12 Advances in PET/MRI and Probe Development for Biomedical Precision
Imaging Applications
Jan Kretschmer, Juan Pellico, Angelina Prytula-Kurkunova, Rafael Torres
Martin De Rosales, Andre Ferreira Martins
Carlos F. G. C. Geraldes received his Licenciatura (MS equivalent) in Chemistry from the University of Coimbra in 1972, and his Doctor of Philosophy (D.Phil) degree in Inorganic Chemistry from the University of Oxford in 1976 with Prof. Robert J. P. Williams. In his graduate work, he studied the solution conformation of a series of mono and dinucleotides using the so-called Lanthanide Probe Method, measuring the proton NMR induced shifts and nuclear relaxation rates of their complexes of whole paramagnetic Ln(III) series combined with coupling constants and NOE data.
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