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PART ONE INTRODUCTION |
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1 Organizational Principles of the Liver |
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2 Embryonic Development of the Liver |
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Roque Bort and Kenneth S. Zaret |
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PART TWO THE CELLS |
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3 Microtubules, Actin Filaments and Motor-mediated Vesicular Transport |
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Ronald R. Marchelletta and Sarah F. Hamm-Alvarez |
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5 Ion Pumps and Molecular Motors: P-, F-, and V-type ATPases |
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Sarah Bond, Daniel J. Cipriano, and Michael Forgac |
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6 Hepatocyte Surface Polarity: Its Dynamic Maintenance and Establishment |
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Lelita T. Braiterman and Ann L. Hubbard |
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7 Endocytosis as an Essential Process in Liver Function and Pathology |
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Barbara Schroeder and Mark McNiven |
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8 Membrane Transport in Hepatocellular Secretion |
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Susan Chi and Mark McNiven |
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11 Protein Maturation and Processing at the Endoplasmic Reticulum |
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12 Protein Degradation and the Lysosomal System |
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Susmita Kaushik and Ana Maria Cuervo |
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13 Peroxisome Assembly, Degradation, and Disease |
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14 Gap and Tight Junctions in Liver: Composition, Regulation, and Function |
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Takashi Kojima, Norimasa Sawada, Hiroshi Yamaguchi, Alfredo G. Fort, and David C. Spray |
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SECTION A HEPATOCYTE |
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15 Copper Metabolism and the Liver |
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Michael L. Schilsky and Dennis J. Thiele |
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16 The Central Role of the Liver in Iron Storage and Regulation of Systemic Iron Homeostasis |
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Tracey A. Rouault, Victor Gordeuk, and Gregory Anderson |
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17 Disorders of Bilirubin Metabolism |
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Namita Roy Chowdhury and Jayanta Roy Chowdhury |
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Peter N. Meissner, Richard J. Hift, Ralph E. Kirsch |
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18 Hepatic fatty acid metabolism and dysfunction |
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19 Lipoprotein Metabolism and Cholesterol Balance |
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SECTION B BILE SECRETION |
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20 Bile Acids and the Enterohepatic Circulation |
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21 Hepatocyte Basolateral Membrane Organic Anion Transporters |
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Jo. H. Choi, John W. Murray, and Allan W. Wolkoff |
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22 Nuclear Receptors Regulate Bile Acid Synthesis |
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Guorong Xu and Gerald Salen |
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GH4.27. Hormonal regulation of bile secretion |
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GH4.28. Nucleotide transport and regulation of bile formation |
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Richard M. Roman and J. Gregory Fitz |
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23 The Function of the Canalicular Membrane in Bile Formation and Secretion |
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Ronald P.J. Oude Elferink and Coen C. Paulusma |
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24 Apical Recycling of Canalicular ABC Transporters |
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Yoshiyuki Wakabayashi and Irwin M. Arias |
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25 Cholangiocyte Functions in Health and Disease: The Ciliary Connection |
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Anatoliy I. Masyuk, Tatyana V. Masyuk, and Nicholas F. LaRusso |
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SECTION C SINUSOIDAL CELLS |
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26 The Hepatic Sinusoidal Endothelial Cell: Morphology, Function, and Pathobiology |
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GH4.30. Endothelial and pit cells |
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Filip Braet, Dianzhong Luo, Ilan Spector, David Vermijlen, Eddie Wisse |
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27 Fenestrations in the Liver Sinusoidal Endothelial Cell |
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Victoria C. Cogger and David G. Le Couteur |
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28 Hepatic Stellate Cells |
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Marcos Rojkind and Karina Reyes-Gordillo |
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Ram´on Bataller and David A. Brenner |
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Giuliano Ramadori and Jozsef Dudas |
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PART THREE INTERRELATED CELL FUNCTIONS |
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Gerald I. Shulman and Varman Samuel |
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32 Ca2+ Signaling in the Liver |
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M. Fatima Leite, Mateus T. Guerra, and Michael H. Nathanson |
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GH4.35 Synthesis of and signalling through D-3 phosphoinositides |
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Rial A Christensen, Isabel De Aos Scherpenseel, Lyuba Varticovski |
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GH4.39. Nitric oxide in the liver |
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33 Role of Intracellular Iron Movement and Oxidant Stress in Hepatocellular Injury |
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John J. Lemasters, Akira Uchiyama, Jae-Sung Kim, Kazuyoshi Kon, and Hartmut Jaeschke |
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GH4.18. Hypoxic, Ischemic and reperfusion injury to liver |
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GH4.19. Protective mechanisms against reactive oxygen species |
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34 Regulatory Pathways of Liver Gene Expression: The Central Role of Cyclic AMP |
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Giuseppe Servillo, Maria Agnese Della Fazia, and Paolo Sassone-Corsi |
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35 AMPK: Central Regulator of Glucose and Lipid Metabolism |
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Maria M. Mihaylova and Reuben J. Shaw |
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GH3.16. Energy Metabolism |
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Sam Seifter and Sasha Englard |
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GH4.40. Interleukin-6 signaling during the acute-phase response of the liver |
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Johannes G. Bode, Peter C. Heinrich |
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GH4.43. Hepatocyte growth factor: its role in hepatic growth and pathobiology |
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Reza Zarnegar, Marie C. Defrances, George K. Michalopoulos |
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37 Ribosome Biogenesis and its Role in Cell Growth and Proliferation in the Liver |
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Stefano Fumagalli and George Thomas |
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GH4.5. Gene regulation and in vivo function of liver transcription factors |
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Robert H. Costa, AI-Xuan Le Holternan, Francisco M. Rausa, Guy R. Adami |
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38 Liver Repopulation by Cell Transplantation and the Role of Stem Cells |
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David A. Shafritz, Michael Oertel, Mariana D. Dabeva, and Markus Grompe |
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PART FOUR RELATION TO OTHER ORGANS |
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39 Hepatic Encephalopathy |
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Roger F. Butterworth and Javier Vaquero |
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40 The Kidney in Liver Disease |
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41 Critical Role of the Liver in Coagulation |
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Robert Fathke, Ze Peng, Basil Golding, and Chava Kimchi-Sarfaty |
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PART FIVE PATHOBIOLOGICAL ANALYSIS |
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42 Inheritable Cholestatic Disorders |
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Paul Gissen and Alex S. Knisely |
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GH4.48. Alpha 1-Antitrypsin deficiency |
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43 Adaptive Regulation of Hepatocyte Transporters in Cholestasis |
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44 Pathogenesis of Portal Hypertension |
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Roberto J. Groszmann and Juan G. Abraldes |
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45 Non-alcoholic Fatty Liver Disease: A Pathophysiological Perspective |
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Michael Fuchs and Arun J. Sanyal |
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46 Pathophysiology of Alcoholic Liver Disease |
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Natalia Nieto and Marcos Rojkind |
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47 Inflammation and Drug-induced Liver Injury |
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Robert A. Roth and Patricia E. Ganey |
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49 Back to the Future: A Backward Glance at the Forward Progress of Hepatitis Virus Research |
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50 Molecular Biology of Hepatitis Viruses |
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Christoph Seeger, Michael M.C. Lai, and William S. Mason |
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51 Immune Mechanisms of Viral Clearance and Disease Pathogenesis During Viral Hepatitis |
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Carlo Ferrari and Mario Mondelli |
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GH4.41. Innate immune sensing and the toll-like receptors |
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52 Clinical Implications of the Molecular Biology of Hepatitis B Virus |
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Timothy M. Block, Ju-Tao Guo, and Thomas W. London |
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53 Viral Escape Mechanisms in Hepatitis C and the Clinical Consequences of Persistent Infection |
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Stanley M. Lemon, Patrizia Farci, and Marc G. Ghany |
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54 Current and Future Therapy for Hepatitis B and C |
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Gary L. Davis and Jean-Michel Pawlotsky |
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55 Biological Principles and Clinical Issues Underlying Liver Transplantation for Virus-induced |
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James R. Burton Jr, Hugo R. Rosen, and Paul Martin |
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PART SIX HORIZONS |
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56 Tissue Engineering of the Liver |
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Gregory H. Underhill, Salman R. Khetani, Alice A. Chen, and Sangeeta N. Bhatia |
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57 Aging and the Uncertain Roles of Sirtuins |
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59 Liver-directed Gene Therapy |
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Betsy T. Kren, Clifford J. Steer, Namita Roy Chowdhury, and Jayanta Roy Chowdhury |
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GH4.63. Novel strategies for manipulating hepatic gene expression in vivo |
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Marxa L. Figueiredo, Eric P. Sandgren |
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60 Decoding the Liver Cancer Genome |
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Ju-Seog Lee and Snorri S. Thorgeirsson |
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61 Genome-wide Expression Profiling of Human Hepatocellular Carcinoma |
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Anuradha Budhu and Xin Wei Wang |
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62 Cell Cycle Control in the Liver |
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Jeffrey H. Albrecht and Lisa K. Mullany |
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63 miRNAs and Liver Biology |
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Charles E. Rogler and Leslie E. Rogler |
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64 Imaging Cellular Proteins and Structures: Smaller, Brighter, and Faster |
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65 Zebrafish as a Model System for the Study of Liver Development and Disease |
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66 The Hepatocyte and the Cancer Cell: Dr Jekyll and Mr Hyde |
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Jean-Pierre Gillet, Michael M. Gottesman, and Mitsunori Okabe |
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67 The Role of Endocannabinoids and Their Receptors in the Control of Hepatic Functions |
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George Kunos, Douglas Osei-Hyiaman, S´andor B´atkai, P´al Pacher, Bin Gao, Won-Il Jeong, Jie Liu, and |
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68 Telomeres and Aging, Cancer, and Hepatic Fibrosis |
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Hans L. Tillmann, Ruben R. Plentz, Yvonne Begus-Nahrmann, Andr´e Lechel, and Lenhard K. Rudolph |
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69 Treatment of Cirrhosis with Vitamin A-coupled Liposomes Carrying siRNA against Heat Shock |
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Yoshiro Niitsu, Yasushi Sato, Kazuyuki Murase, and Junji Kato |
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70 The “Green Liver” and Transcriptional Regulation of Phase II Detoxification Genes |
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Christopher Johnson and Jonathan Arias |
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