The fourth edition of this authoritative text covers every aspect of liver disease affecting infants, children and adolescents. As in the previous editions, it offers an integrative approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. All of the chapters are written by international experts and address the unique pathophysiology, manifestations and management of these disorders. This edition of the landmark text features extended coverage of viral hepatitis, metabolic liver disease, fatty liver disease and liver transplantation, including a new chapter on post-transplant care and outcomes. All of the chapters have been updated to reflect changing epidemiology and recent advances in molecular medicine and genomics. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.
Recenzijas
Review of previous edition: 'The essential pediatric hepatology textbook.' New England Journal of Medicine Review of previous edition: 'Well written and organized builds on a strong scientific foundation and effectively bridges pathophysiologic principles with clinical practice, providing authoritative updated reviews on all topics relevant to the discipline. The textbook is the premier reference in the field and should be truly enjoyed by primary care practitioners, gastroenterologists, hepatologists, and anyone genuinely interested in the care of children with liver disease.' Journal of the American Medical Association Review of previous edition: 'The text is accompanied by an excellent selection of color plates and is generally well illustrated throughout the authors are to be congratulated for tapping the writing skills of some of the foremost experts in pediatric hepatology for the text.' Pediatric Gastroenterology
Papildus informācija
Provides comprehensive and authoritative coverage of every aspect of liver disease affecting infants, children and adolescents.
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vii | |
| Preface |
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Section I Pathophysiology of pediatric liver disease |
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1 | (100) |
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1 | (9) |
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2 Functional development of the liver |
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10 | (14) |
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3 Mechanisms of bile formation and cholestasis |
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24 | (8) |
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4 Acute liver failure in children |
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32 | (19) |
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5 Cirrhosis and chronic liver failure |
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51 | (17) |
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68 | (20) |
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7 Laboratory assessment of liver function and injury in children |
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88 | (13) |
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Section II Cholestatic liver disease |
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101 | (164) |
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8 Approach to the infant with cholestasis |
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101 | (10) |
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9 Medical and nutritional management of cholestasis in infants and children |
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111 | (29) |
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10 Neonatal hepatitis and congenital infections |
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140 | (15) |
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11 Biliary atresia and other disorders of the extrahepatic bile ducts |
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155 | (22) |
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12 Neonatal jaundice and disorders of bilirubin metabolism |
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177 | (22) |
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13 Familial hepatocellular cholestasis |
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199 | (17) |
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216 | (18) |
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15 Intestinal failure-associated liver disease |
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234 | (13) |
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16 Disease of the gallbladder in infancy, childhood, and adolescence |
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247 | (18) |
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Section III Hepatitis and immune disorders |
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265 | (122) |
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17 Hepatitis A and hepatitis E virus infection |
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265 | (11) |
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18 Hepatitis B virus infection |
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276 | (19) |
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19 Hepatitis C virus infection |
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295 | (16) |
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311 | (11) |
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21 Sclerosing cholangitis |
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322 | (19) |
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22 Drug-induced liver disease |
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341 | (29) |
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23 Liver disease in immunodeficiencies |
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370 | (17) |
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Section IV Metabolic liver disease |
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387 | (286) |
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24 Laboratory diagnosis of inborn errors of metabolism |
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387 | (13) |
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25 α1Antitrypsin deficiency |
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400 | (19) |
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26 Cystic fibrosis liver disease |
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419 | (16) |
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27 Inborn errors of carbohydrate metabolism |
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435 | (30) |
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28 Copper metabolism and copper storage disorders |
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465 | (28) |
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29 Iron storage disorders |
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493 | (16) |
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30 Heme biosynthesis and the porphyrias |
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509 | (17) |
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526 | (20) |
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32 Lysosomal storage disorders |
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546 | (21) |
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33 Disorders of bile acid synthesis and metabolism |
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567 | (20) |
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34 Inborn errors of fatty acid oxidation |
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587 | (16) |
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35 Mitochondrial hepatopathies |
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603 | (28) |
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36 Non-alcoholic fatty liver disease in children |
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631 | (18) |
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649 | (15) |
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664 | (9) |
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Section V Other considerations and issues in pediatric hepatology |
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673 | (115) |
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39 Bacterial, parasitic, and fungal infections of the liver |
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673 | (21) |
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40 Systemic disease and the liver |
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694 | (16) |
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41 Fibrocystic liver disease |
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710 | (18) |
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728 | (32) |
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43 Liver transplantation in children: indications and surgical aspects |
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760 | (13) |
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44 Liver transplantation in children: post-transplant care |
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773 | (15) |
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| Index |
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788 | |
Frederick J. Suchy, MD is Chief Research Officer and Director, The Children's Hospital Research Institute, Children's Hospital Colorado. He is also Professor of Pediatrics and Associate Dean for Child Health Research, University of Colorado School of Medicine, Aurora, CO, USA. Ronald J. Sokol, MD is Professor and Vice Chair of Pediatrics, Section Head, Gastroenterology, Hepatology and Nutrition, Director, Colorado Clinical and Translational Sciences Institute, and holds the Arnold Silverman MD Chair in Digestive Health, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA. William F. Balistreri, MD is Director Emeritus of the Pediatric Liver Care Center, Medical Director Emeritus, Liver Transplantation, and Dorothy M. M. Kersten Professor of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition at the Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
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