E-grāmata: Lock-and-Key Principle: The State of the Art--100 Years On

This is the first volume of a new series that will cover recent developments and new approaches in the molecular chemistry beyond the covalent bond. Around 100 years ago Emil Fischer proposed that enzyme and substrate can be compared to lock and key, a metaphor that is still used to describe enzyme action. In this volume, the impact of the lock-and-key principle on the chemical, biomedical, and materials sciences is discussed in eight contributions of interdisciplinary interest. Among the topics: models for analysis of protein-ligand interactions, macrocytes and antibodies as catalysts, and perspectives on the field from the lock-and-key image to the information paradigm. Annotation copyright Book News, Inc. Portland, Or.

Perspectives in Supramolecular Chemistry will relate recent developments and new exciting approaches in supramolecular chemistry. In supramolecular chemistry, our aim is to understand the molecular chemistry beyond the covalent bond—the series will concentrate on goal-orientated supramolecular chemistry. Perspectives in Supramolecular Chemistry will reflect research which develops supramolecular structures with specific new properties, such as recognition, transport and simulation of biosystems or new materials. The series will cover all areas from theoretical and modelling aspects through organic and inorganic chemistry and biochemistry to materials, solid-state and polymer sciences, reflecting the many and varied applications of supramolecular structures in modern chemistry. The Lock and Key Principle The State of the Art—100 Years on Edited by Jean-Paul Behr Published 100 years after Emil Fischer first proposed the lock-and-key principle, this volume provides a complete review of the subject to date and offers suggestions for further research. The major impact of the lock-and-key principle on the chemical, biomedical and materials sciences is discussed by leaders in the field, with chapters dedicated to molecular recognition, nucleic acid and protein chemistry, crystallography and the development of Emil Fischer’s initial ideas. The Lock-and-Key Principle is the most up-to-date review of progress in supramolecular chemistry and the lock-and-key principle, and will become the essential guide to the past, present and future of this remarkable idea. The interdisciplinary nature of this topic is highlighted in The Lock-and-Key Principle ensuring that this volume is essential reading for chemists, molecular biologists, biochemists and materials scientists working in the areas of molecular recognition, enzymology, immunology, protein and nucleic acid chemistry, crystallography, bioinorganic and bioorganic chemistry and supramolecular chemistry