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xiii | |
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xvii | |
Preface |
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xix | |
Acknowledgments |
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xxiii | |
Author Bio |
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xxv | |
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1 | (22) |
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1 | (1) |
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1.2 Types of Research Studies |
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2 | (1) |
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1.3 Sources of Medical Data |
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2 | (1) |
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1.4 Measures of Central Tendency |
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3 | (2) |
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1.5 Data Sampling and Its Types |
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5 | (1) |
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1.5.1 Probability Sampling Methods |
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5 | (1) |
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1.5.2 Non-probability Sampling Methods |
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6 | (1) |
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1.6 Statistical Significance Analysis |
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6 | (4) |
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10 | (1) |
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11 | (3) |
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13 | (1) |
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13 | (1) |
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14 | (1) |
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14 | (1) |
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1.9.1 Linear and Non-linear Relationship |
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14 | (1) |
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1.9.2 Use of Curve-Fitting Method |
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14 | (1) |
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14 | (4) |
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1.10.1 Pearson Correlation (PC) |
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15 | (1) |
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1.10.2 Spearman Rank Correlation (SRC) |
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16 | (2) |
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18 | (5) |
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18 | (1) |
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1.11.2 Estimation of Regression Coefficients |
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19 | (4) |
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Chapter 2 Probability Theory |
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23 | (12) |
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2.1 Basic Concept of Probability |
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23 | (1) |
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24 | (1) |
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2.3 Conditional Probability |
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24 | (2) |
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25 | (1) |
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26 | (2) |
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28 | (1) |
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2.6 Distribution Functions |
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28 | (3) |
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2.6.1 Binomial Distribution |
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29 | (1) |
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2.6.2 Poisson Distribution |
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30 | (1) |
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2.6.3 Normal Distribution |
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30 | (1) |
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31 | (1) |
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32 | (1) |
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32 | (3) |
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Chapter 3 Medical Data Acquisition and Pre-processing |
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35 | (10) |
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35 | (3) |
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3.1.1 Data Formats for Medical Images |
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35 | (1) |
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3.1.1.1 DICOM (Digital Imaging and Communications in Medicine) |
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36 | (1) |
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36 | (1) |
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3.1.1.3 NlfTI (Neuroimaging Informatics Technology Initiative) |
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36 | (1) |
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3.1.1.4 MINC (Medical Imaging NetCDF) |
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36 | (1) |
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3.1.2 Medical Data Formats for Signals |
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37 | (1) |
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3.1.2.1 EDF (European Data Format) |
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37 | (1) |
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3.1.2.2 BDF (BioSemi Data Format) |
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37 | (1) |
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3.1.2.3 GDF (General Data Format) |
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38 | (1) |
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3.2 Data Augmentation and Generation |
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38 | (1) |
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38 | (1) |
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39 | (3) |
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3.4.1 Statistical Approach |
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40 | (1) |
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3.4.1.1 Listwise Deletion |
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40 | (1) |
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3.4.1.2 Pairwise Deletion |
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40 | (1) |
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3.4.1.3 Multiple Imputation |
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40 | (1) |
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3.4.1.4 Maximum Likelihood Imputation |
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41 | (1) |
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3.4.2 Machine Learning for Data Imputation |
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41 | (1) |
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3.4.2.1 K-Nearest Neighbour (KNN) |
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41 | (1) |
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3.4.2.2 Bayesian Network (BN) |
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41 | (1) |
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42 | (3) |
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Chapter 4 Medical Image Processing |
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45 | (20) |
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4.1 Medical Image Modalities, Their Applications, Advantages and Limitations |
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45 | (4) |
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46 | (1) |
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46 | (1) |
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4.1.2.1 Positron Emission Tomography (PET) |
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46 | (1) |
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46 | (1) |
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4.1.4 Photoacoustic Imaging |
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47 | (1) |
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47 | (1) |
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4.1.6 Magnetic Resonance Imaging (MRI) |
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47 | (1) |
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4.1.7 Ultrasound Imaging Techniques |
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48 | (1) |
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4.2 Medical Image Enhancement |
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49 | (2) |
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51 | (5) |
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4.4 Medical Image De-noising |
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56 | (3) |
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56 | (1) |
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56 | (2) |
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4.4.1.2 Non-linear Filters |
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58 | (1) |
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4.4.2 Transform Domain Filtering |
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58 | (1) |
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4.4.2.1 Non-data Adaptive Transform |
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58 | (1) |
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4.4.2.2 Data-Adaptive Transforms |
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59 | (1) |
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59 | (1) |
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59 | (6) |
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4.6.1 Region-Growing Segmentation |
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61 | (4) |
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65 | (12) |
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5.1 Origin of Bio-signals |
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65 | (1) |
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5.2 Different Types of Bio-signals |
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65 | (7) |
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65 | (3) |
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5.2.2 Electroencephalogram (EEG) |
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68 | (1) |
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5.2.3 Electroocculogram (EOG) |
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69 | (1) |
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5.2.4 Electromyogram (EMG) |
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69 | (3) |
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72 | (1) |
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5.4 Filtering of Bio-signals |
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73 | (1) |
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5.5 Applications of Bio-signals |
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74 | (3) |
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Chapter 6 Feature Extraction |
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77 | (30) |
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77 | (1) |
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6.2 Echographic Characteristics of Breast Tumours in Ultrasound Imaging |
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78 | (1) |
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6.3 Texture Feature Extraction |
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78 | (22) |
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6.3.1 First-Order Statistical Features |
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78 | (4) |
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6.3.2 Grey-Level Co-occurrence Matrices |
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82 | (5) |
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6.3.3 Grey-Level Difference Statistics |
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87 | (1) |
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6.3.4 Neighbourhood Grey-Tone Difference Matrix |
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88 | (3) |
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6.3.5 Statistical Feature Matrix |
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91 | (1) |
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6.3.6 Texture Energy Measures |
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92 | (1) |
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6.3.7 Fractal Dimension Texture Analysis |
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93 | (2) |
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6.3.8 Spectral Measures of Texture |
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95 | (1) |
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6.3.9 Run-Length Texture Features |
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96 | (4) |
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6.4 Shape Feature Extraction |
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100 | (2) |
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100 | (1) |
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100 | (2) |
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6.5 Feature Normalization |
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102 | (5) |
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6.5.1 Brief Overview of Feature Normalization Techniques |
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102 | (5) |
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Chapter 7 Introduction to Machine Learning |
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107 | (28) |
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7.1 Introduction: What Is Machine Learning? |
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107 | (1) |
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7.2 Classification of Machine Learning (ML) Methods |
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108 | (1) |
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7.3 Steps in Implementation of Machine Learning |
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109 | (4) |
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7.4 Training, Testing and Validation |
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113 | (1) |
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7.5 Machine Learning Methods |
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114 | (16) |
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7.5.1 Supervised Learning |
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114 | (11) |
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7.5.2 Unsupervised Learning |
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125 | (5) |
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7.6 Performance Evaluation of Machine Learning Model |
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130 | (5) |
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Chapter 8 Cancer Detection: Breast Cancer Detection Using Mammography, Ultrasound and Magnetic Resonance Imaging (MRI) |
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135 | (18) |
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135 | (1) |
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8.2 Different Imaging Modalities |
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136 | (5) |
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136 | (1) |
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137 | (3) |
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8.2.3 Magnetic Resonance Imaging (MRI) |
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140 | (1) |
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8.3 Breast Imaging Reporting and Data System (BI-RADS) |
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141 | (1) |
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8.4 Usefulness of Machine Learning (ML) |
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141 | (6) |
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8.4.1 Image Pre-processing |
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142 | (1) |
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143 | (1) |
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143 | (2) |
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145 | (1) |
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146 | (1) |
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8.4.6 Performance Evaluation |
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147 | (1) |
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8.5 Issues and Challenges |
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147 | (2) |
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149 | (4) |
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Chapter 9 Sickle Cell Disease Management: A Machine Learning Approach |
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153 | (18) |
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153 | (2) |
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9.2 Severity Detection of Sickle Cell Disease |
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155 | (4) |
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9.2.1 Analysis of Clinical Complications |
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156 | (1) |
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9.2.2 Analysis of Clinical Attributes |
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156 | (2) |
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9.2.3 Analysis of Microscopic Images of RBC |
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158 | (1) |
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9.3 Hydroxyurea Dosage Prediction for SCD Patients |
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159 | (6) |
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9.4 Patient Response to Medications through Hydroxyurea (HU) |
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165 | (3) |
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9.5 SCD Management Proposed Model |
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168 | (1) |
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168 | (3) |
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Chapter 10 Detection of Pulmonary Disease |
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171 | (20) |
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10.1 Introduction to Pulmonary Disorders |
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171 | (1) |
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10.2 Restrictive and Obstructive Lung Diseases |
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172 | (2) |
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10.2.1 Obstructive Lung Disease |
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172 | (1) |
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10.2.2 Restrictive Lung Disease |
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173 | (1) |
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10.3 Diagnosis of Disease and Disorder |
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174 | (1) |
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175 | (1) |
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176 | (3) |
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179 | (1) |
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10.7 Arterial Blood Gas Analysis |
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180 | (1) |
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180 | (1) |
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181 | (1) |
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182 | (1) |
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10.11 Pulmonary Function Test |
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183 | (2) |
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10.12 Challenges and Issues |
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185 | (1) |
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10.13 Application of Machine Learning in Diagnosis of Pulmonary Disorder |
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186 | (2) |
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188 | (3) |
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Chapter 11 Mental Illness and Neurodevelopmental Disorders |
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191 | (22) |
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11.1 Neurodevelopmental Disorders |
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191 | (1) |
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11.2 Developmental Dyslexia |
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191 | (4) |
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11.2.1 Diagnostic Methods |
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192 | (1) |
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11.2.2 Behavioural Method |
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192 | (1) |
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11.2.3 Brain Imaging Modalities |
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193 | (1) |
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11.2.4 Recent Advancement in Diagnostic Techniques |
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193 | (2) |
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11.3 Attention-Deficit/Hyperactivity Disorder (ADHD) |
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195 | (3) |
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195 | (1) |
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195 | (1) |
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196 | (1) |
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11.3.4 Diagnosis Based on Brain Imaging and Machine Learning Methods |
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196 | (1) |
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11.3.5 Treatment for ADHD |
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197 | (1) |
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198 | (5) |
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11.4.1 Parkinson's Disease Prognosis and Measurement Rating Scales |
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199 | (1) |
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199 | (1) |
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199 | (1) |
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11.4.2 Involvement of Digital Technologies for Detection and Monitoring of PD |
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200 | (3) |
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203 | (2) |
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11.5.1 Recent Literatures on Epilepsy Detection |
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203 | (1) |
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11.5.2 Generalized Machine Learning Model for Epilepsy Detection System |
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204 | (1) |
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205 | (8) |
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206 | (1) |
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11.6.2 A Machine Learning Model for Schizophrenia Detection |
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206 | (7) |
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Chapter 12 Applications and Challenges |
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213 | (12) |
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12.1 Role of Machine Learning in Healthcare Research |
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213 | (1) |
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12.2 Efficient Diagnosis of Diabetes |
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214 | (1) |
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215 | (1) |
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216 | (1) |
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217 | (2) |
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219 | (1) |
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12.7 Digital Health Records |
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220 | (1) |
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12.8 Future Research Challenges |
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221 | (4) |
Index |
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225 | |