Klientu atbalsts: 27018494

Grāmatu iegāde | Jauns profils | Ienākt

E-grāmata: Mass Spectrometry in Cancer Research

John Roboz (Mount Sinai School of Medicine, New York, NY, USA)

Formāts: 576 pages
Izdošanas datums: 25-Mar-2002
Izdevniecība: CRC Press Inc
Valoda: eng
ISBN-13: 9781420042696

Citas grāmatas par šo tēmu:

Spectrum analysis, spectrochemistry, mass spectrometry

Formāts - PDF+DRM
Cena: 212,89 €*
* ši ir gala cena, t.i., netiek piemērotas nekādas papildus atlaides
Ielikt grozā
Pievienot vēlmju sarakstam
Šī e-grāmata paredzēta tikai personīgai lietošanai. E-grāmatas nav iespējams atgriezt un nauda par iegādātajām e-grāmatām netiek atmaksāta.

Formāts: 576 pages
Izdošanas datums: 25-Mar-2002
Izdevniecība: CRC Press Inc
Valoda: eng
ISBN-13: 9781420042696

Citas grāmatas par šo tēmu:

Spectrum analysis, spectrochemistry, mass spectrometry

DRM restrictions

Kopēšana (kopēt/ievietot):

nav atļauts
Drukāšana:

nav atļauts
Lietošana:

Digitālo tiesību pārvaldība (Digital Rights Management (DRM))
Izdevējs ir piegādājis šo grāmatu šifrētā veidā, kas nozīmē, ka jums ir jāinstalē bezmaksas programmatūra, lai to atbloķētu un lasītu. Lai lasītu šo e-grāmatu, jums ir jāizveido Adobe ID. Vairāk informācijas šeit. E-grāmatu var lasīt un lejupielādēt līdz 6 ierīcēm (vienam lietotājam ar vienu un to pašu Adobe ID).

Nepieciešamā programmatūra
Lai lasītu šo e-grāmatu mobilajā ierīcē (tālrunī vai planšetdatorā), jums būs jāinstalē šī bezmaksas lietotne: PocketBook Reader (iOS / Android)

Lai lejupielādētu un lasītu šo e-grāmatu datorā vai Mac datorā, jums ir nepieciešamid Adobe Digital Editions (šī ir bezmaksas lietotne, kas īpaši izstrādāta e-grāmatām. Tā nav tas pats, kas Adobe Reader, kas, iespējams, jau ir jūsu datorā.)

Jūs nevarat lasīt šo e-grāmatu, izmantojot Amazon Kindle.

Offering broad coverage of current strategies and techniques, this book examines the application of mass spectrometry in occupational and environmental carcinogens, antineoplastic and chemopreventive agents, and pertinent proteins, lipids, nucleic acids, and glyconojugates. The basic concepts of cancer biology and medicine are reviewed, and instrumentation is discussed. The book is intended for mass spectrometrists, researchers, and doctors. Two hundred-forty figures and 30 tables are included. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Cancer research is becoming multidisciplinary. The complex structural and therapeutic problems require synergistic approaches employing an assortment of biochemical manipulations, chromatographic or electrophoretic separations, sequencing strategies, and … more and more mass spectrometry.

Mass Spectrometry in Cancer Research provides a broad examination of current strategies and techniques and their application to the study of:
(i) occupational and environmental carcinogens;
(ii) antineoplastic and chemopreventive agents;
(iii) pertinent proteins, lipids, nucleic acids and glycoconjugates. Also included are a chapter on instrumentation and methodologies for biologists and physicians and a brief review of the relevant concepts of cancer biology and medicine for mass spectrometrists.

This book is intended for: mass spectrometrists in research or those providing core services; researchers in biological, medical, pharmaceutical or environmental sciences; physicians in academic medicine; and academic/industrial research managers.

Recenzijas

"This is a unique and very useful tool for biologists interested in mass spectrometry. Written with biologists in mind, it provides a good background for novices in the field and illustrates the potential of mass spectrometry in molecular biology and oncology. it serves to connect these fields for a wide range of scientists. 4 stars!" - Victor V. Levenson, MD, PhD, Northwestern University Medical School, Doody's Notes

"an invaluable resource for mass spectrometrists. The text provides a myriad of experimental applications and strategies for the MS analyses of molecules that are central to the development and prevention of cancer. All mass spectrometrists who are interested in doing cancer research should procure a copy." - M. Paul Chiarellia, Loyola University, in Journal of the American Society for Mass Spectrometry, Volume 14, Issue 1

About the Author

xiii

Foreword

Mass Spectrometry: An Oncologist's Viewpoint

xvii

Preface

xix

Acknowledgments

xxi

Terminology and Abbreviations

(544)

Overview and Scope of Applications

(18)

The Essentials

(2)

Functions and Types of Instrument Components

(8)

Sample Introduction Systems

(2)

Ion Sources

(3)

Mass Analyzers

(2)

Ion Detectors

(1)

Vacuum Systems

(1)

Data Systems

(1)

Measures of Performance

(2)

Resolution and Resolving Power

(1)

Mass Range

(1)

Mass Accuracy

(1)

Scan Speed

(1)

Specificity Sensitivity and Limit of Detection

(1)

Information from Mass Spectra and Scope of Applications

(6)

Instrumentation and Techniques of Mass Spectrometry

(58)

Ion Sources

(13)

Electron Ionization

(1)

Chemical Ionization

(1)

Atmospheric Pressure Chemical Ionization

(1)

Electrospray Ionization

(3)

Nano-Electrospray

(1)

Microfabricated Silicone Chip-Based Electrospray Ion Sources

(1)

Multiplexed Electrospray

(1)

Fast Atom and Ion Bombardment

(1)

Matrix-Assisted Laser Desorption Ionization

(2)

Surface-Enhanced Laser Desorption Ionization (SELDI)

(1)

Photoionization

(1)

Direct Laser Desorption Ionization

(1)

Resonance-Enhanced Multiphoton Ionization

(1)

Inductively Coupled Plasma

(1)

Miscellaneous Ionization Techniques

(1)

Secondary Ion Mass Spectrometry

(1)

Field Ionization and Field Desorption

(1)

Californium-252 Plasma Desorption

(1)

Glow Discharge

(1)

Spark Source

(1)

Thermal Ionization

(1)

Mass Analyzers

(13)

Time-of-Flight Analyzers

(2)

Orthogonal Acceleration TOF

(1)

Reflectrons (Ion Mirrors)

(1)

Delayed Extraction

(1)

Quadrupole Analyzers

(2)

Quadrupoles as Ion Guides

(1)

Hexapoles

(1)

Quadrupole Ion Traps

(1)

Magnetic Analyzers

(1)

Magnetic Sector and Electrostatic Analyzers

(2)

Fourier Transform Ion-Cyclotron Resonance Analyzers

(1)

Tandem Analyzers

(1)

Magnetic Analyzers as Components of Tandem Systems

(1)

Quadrupole-Time-of-Flight Hybrid Analyzer

(1)

Hexapole-TOF Hybrid Analyzer

(1)

Accelerator Mass Spectrometry

(1)

Ion Current Detectors

(3)

Single Point Ion Collectors

(1)

Faraday Cup Detectors

(1)

Secondary Electron Multipliers

(1)

Scintillation Counters

(1)

Multipoint (Array) Detectors

(1)

Interfaces for Sample Introduction

(7)

Gases and Volatile Liquids

(1)

Reservoir and Batch Inlets

(1)

Membrane Inlets

(1)

Static Direct Inlet Probes

(1)

Interfaces for Coupling with Gas Chromatographs

(1)

Interfaces for Coupling with Liquid Chromatographs

(1)

Interfaces for Coupling with Capillary Electrophoresis Systems

(2)

High Throughput Inlets and Microfabricated Fluidic Systems

(1)

Mass Spectrometry/Mass Spectrometry (MS/MS)

(4)

Ion Activation Methods

(1)

Metastable Ions

(1)

Collision-Induced Dissociation

(1)

Electron-Capture Dissociation

(1)

Photodissociation and Surface-Induced Dissociation

(1)

In-Source Fragmentation

(1)

Tandem-in-Space (Transmission) Techniques

(1)

Product-Ion Scanning Mode

(1)

Precursor Scanning Mode

(1)

Constant Neutral Loss Scanning Mode

(1)

Selected Reaction Monitoring

(1)

Post-Source Decay

(1)

Tandem-in-Time (Trapped-Ion) Techniques

(1)

Identification and Quantification

(6)

Mass Spectral Libraries and Bioinformatics

(1)

Accurate Mass Measurement

(1)

Selected Ion and Reaction Monitoring

(1)

Selected Ion Monitoring

(2)

Selected Reaction Monitoring

(1)

Stable Isotope Dilution

(2)

Resources

(12)

Relevant Concepts of Cancer Medicine and Biology

(26)

Classification and Epidemiology

(4)

Solid Tumors

(1)

Hematologic Malignancies

(1)

Incidence and Distribution of Cancers

(1)

Risk Factors

(2)

Cellular Proliferation and Communication

(5)

Growth Patterns

(1)

Cell Cycle

(3)

Cellular Communication and Signal Transduction

(1)

Genetic Abnormalities in Cancer

(5)

Cancer as a Genetic Disorder of Somatic Cells

(1)

Mutation

(1)

Oncogenes

(3)

Tumor Suppressor Genes

(1)

Carcinogenesis Requires an Accumulation of Mutations

(1)

Tumor Immunology

(3)

Hematopoiesis

(1)

Antigens and Antibodies

(1)

Types of Immune Response

(1)

Diagnosis and Treatment

(3)

Clinical Presentation

(1)

Diagnostic Work up

(2)

Treatment Modalities

100

(1)

Functional Status Complications and Causes of Death

101

(1)

Some Pertinent Experimental Methods

101

(6)

DNA and RNA Analysis

101

(1)

Polymerase Chain Reaction

102

(1)

Determination of Clonality

102

(1)

Cell Cultures

103

(1)

Experimental Mouse Models

104

(1)

Recommended Books

105

(2)

Metabolism and Biomarkers of Carcinogens

107

(94)

Classification, Mechanism of Action and Biomarkers

107

(10)

Classification and Risk Assessment

107

(1)

Risk Assessment

108

(1)

Metabolism Enzymatic Activation and Mechanism of Action

109

(1)

Absorption Distribution and Storage

109

(2)

Key Steps in Chemical Carcinogenesis

111

(1)

Functions of Phase I and II Enzymes

112

(1)

Methodologies for Biomarkers

113

(1)

DNA Adducts

113

(3)

Hemoglobin Adducts

116

(1)

Occupational Carcinogens

117

(20)

Aromatic Hydrocarbons

117

(1)

Benzene

117

(5)

Risk Assessment of Polycyclic Aromatic Hydrocarbons in Coke Workers

122

(3)

Gasoline and Diesel Exhaust

125

(1)

Aromatic Amines

125

(1)

Benzidine

125

(2)

Miscellaneous

127

(1)

Plastic Monomers

128

(1)

Acrylonitrile

128

(1)

Ethylene and Propylene Oxides

129

(2)

Vinyl Chloride

131

(1)

Butadiene

132

(1)

Styrene and Styrene Oxide

133

(1)

Exposure by Health Care Personnel to Cytotoxic Drugs

134

(3)

Environmental Carcinogens

137

(42)

Tobacco

137

(1)

Quantification of Nicotine and Its Metabolites

137

(5)

Benzene and Polycyclic Aromatic Hydrocarbons

142

(1)

4-Aminobiphenyl

143

(3)

Tobacco-Specific N-Nitrosamines

146

(6)

Air

152

(1)

Gasoline and Diesel Fuels

152

(3)

Polycyclic Aromatic Hydrocarbons

155

(1)

Monitoring Miscellaneous Complex Mixtures

156

(2)

Food

158

(1)

Aflatoxins

158

(3)

Heterocyclic Aromatic Amines

161

(7)

Nitrosamines

168

(2)

Polycyclic Aromatic Hydrocarbons

170

(1)

Dioxins and Pesticides

170

(1)

Water and Soil

171

(1)

Membrane Inlet Mass Spectrometry

171

(1)

Carcinogen Identification in Well Water by High-Resolution MS

172

(1)

Vinyl Chloride Monomer in Drinking Water

173

(1)

Phenolic Xenoestrogens in Water

174

(1)

Mutagenic Heterocyclic Amines in the Danube River

174

(1)

Polycyclic Aromatic Hydrocarbons in Soils

174

(2)

Composted Municipal Sludge and Compost-Amended Soil

176

(1)

Helicobacter Pylori

176

(1)

Elements

177

(1)

Arsenic

177

(1)

Selenium

178

(1)

Chromium

179

(1)

DNA Damage by Radiation and Oxidation

179

(22)

References

180

(21)

Mechanism of Action and Metabolism of Antineoplastic and Chemopreventive Agents

201

(160)

Cytotoxic Therapy

201

(70)

Basic Principles

201

(1)

Cell Kill Hypothesis Classification and Mechanisms of Action

201

(3)

Toxicity Resistance and Combination Chemotherapy

204

(2)

Drug Discovery and Development Clinical Trials

206

(5)

Alkylating Agents

211

(1)

Mechanism of Action

211

(1)

Nitrogen Mustards

211

(13)

Alkyl Sulfonates

224

(3)

Nitrosoureas

227

(1)

Nonclassic Alkylating Agents

228

(1)

Platinum Compounds

229

(8)

Topoisomerase Inhibitors

237

(1)

Topoisomerase I Inhibitors

238

(5)

Topoisomerase II Inhibitors

243

(11)

Antimicrotubule Agents

254

(1)

Microtubules and Tubulins

254

(2)

Vinca Alkaloids

256

(2)

Taxanes

258

(5)

Miscellaneous

263

(2)

Antimetabolites

265

(1)

Purine and Pyrimidine Analogs

265

(3)

Antifolates

268

(3)

Opportunistic Fungal Infections

271

(1)

Endocrine Therapy

271

(18)

Mechanism of Action

271

(1)

Aromatase Inhibitors

271

(2)

Structure and Function

273

(1)

Nonsteroidal Inhibitors

273

(2)

Steroidal Inhibitors

275

(2)

Aromatase Inhibitory Activity of Androgens

277

(1)

Antiestrogens

278

(1)

Tamoxifen

278

(10)

Toremifene

288

(1)

Targeted Drug Delivery and Therapy

289

(16)

Drugs Conjugated to Proteins Antibodies or Lipids

289

(1)

Angiogenesis Inhibitors

290

(9)

Antisense Oligonucleotides

299

(2)

Ras Oncoprotein Inhibitors

301

(1)

Antibody-Directed Enzyme Prodrug Therapy

302

(1)

Miscellaneous Strategies for Targeting

302

(1)

Photodynamic Therapy

302

(2)

Differentiating Agents

304

(1)

Arsenic Trioxide

304

(1)

Nutritional and Chemical Prevention

305

(56)

Objectives and Classifications

305

(2)

Phytoestrogens

307

(1)

Multicomponent Analysis in Food

308

(4)

Multicomponent Analysis in Body Fluids

312

(4)

Metabolism and Antineoplastic Effects

316

(5)

Flavan-3-ols (Catechins)

321

(1)

Tea

321

(1)

Wine

321

(1)

Terpenes and Ginsenosides

322

(1)

Metabolism of d-Limonene

322

(3)

Ginsenosides

325

(1)

Carotenoids

325

(2)

Sulfur-Containing Compounds

327

(1)

Isothiocyanates

327

(2)

Garlic

329

(1)

Oltipraz and N-acetylcysteine

330

(1)

Retinoids, Vitamins, and Selenium

331

(1)

Retinoids

331

(1)

Vitamin E

332

(1)

Selenium

333

(1)

References

333

(28)

Strategies Techniques and Applications in Cancer Biochemistry and Biology

361

(184)

Proteins and Peptides

361

(99)

Proteome Technology

361

(1)

Proteomics and Strategies of Proteome Analysis

361

(4)

Protein Isolation Digestion and Delivery into the Ion Source Instrumentation

365

(4)

Sequencing by Edman Degradation

369

(1)

Mass Spectrometric Peptide Mapping

370

(1)

Peptide Ladder Sequencing

371

(1)

Sequencing by Tandem Mass Spectrometry

372

(5)

Protein Identification by Database Searches

377

(4)

Mass Measurement of Intact Proteins

381

(2)

Quantification

383

(2)

Posttranslational Modifications

385

(2)

Phosphorylation

387

(8)

Selected Other Posttranslational Modifications

395

(3)

Miscellaneous Proteins

398

(1)

Enzymes

398

(4)

Antigens

402

(1)

Non-Glycosylated Cytokines

403

(4)

Tumor-Associated Proteins

407

(1)

Tumor Proteomics

407

(2)

Hematologic Malignancies

409

(9)

Gynecologic Malignancies

418

(6)

Genitourinary Malignancies

424

(4)

Gastrointestinal Malignancies

428

(6)

Other Cancers

434

(3)

Peptides and Class I Major Histocompatibility Complexes

437

(1)

Class I MHC Molecules

437

(3)

Strategies and Techniques

440

(2)

Peptide Antigens in Malignancies

442

(7)

Noncovalent Interactions and Protein Folding

449

(1)

Protein-Ligand Interactions

449

(1)

Protein-Protein Interactions

450

(3)

Protein-DNA Interactions

453

(2)

Protein Conformation and Folding

455

(5)

Lipids

460

(12)

Ceramides

462

(6)

Eicosanoids

468

(2)

Lysophospholipids

470

(1)

Platelet-Activating Factor

471

(1)

Oligonucleotides and Nucleic Acids

472

(14)

Mass Spectra

472

(1)

Nomenclature of Fragmentation

472

(1)

Electrospray Ionization

473

(1)

MALDI-TOFMS

474

(1)

High-Resolution MALDI-FTICRMS

474

(1)

Analysis of Large Nucleic Acids

475

(1)

Techniques and Strategies

475

(1)

Polymerase Chain Reaction

475

(1)

Differential Sequencing

476

(1)

Mass Spectrometric Methods for Genotyping

476

(4)

Detection of Mutation

480

(1)

DNA Sequencing and Genetic Diagnosis

480

(1)

Sequencing Exons of the p53 Gene

480

(1)

Identifying Microsatellite Alleles

481

(1)

Familial Adenomatous Polyposis

482

(1)

Multiple Endocrine Neoplasia Type 2A

483

(2)

Breast Cancer Susceptibility Gene BRCA1

485

(1)

Carbohydrates and Glycoconjugates

486

(59)

Carbohydrates

486

(1)

Nomenclature and Techniques for Collision-Induced Dissociation

486

(2)

Sialic Acids

488

(1)

Polysaccharides and Glycosaminoglycans

488

(1)

Glycosylation

489

(2)

Glycoproteins

491

(1)

Mucins

492

(7)

Antigens

499

(4)

Miscellaneous Glycoproteins

503

(6)

Glycolipids (Gangliosides) in Various Malignancies

509

(9)

Recommended Books

518

(1)

References

518

(27)

Index

545

Biežāk uzdotie jautājumi par e-grāmatām

Permanent link: https://www.kriso.lv/db/97814200426962e.html

Keywords:

E-grāmata: Mass Spectrometry in Cancer Research

DRM restrictions

Kopēšana (kopēt/ievietot):

Drukāšana:

Lietošana:

Recenzijas

Konts un iestatījumi

Meklēšana

Meklēt datubāzē

Refine By

Tēmas Ebook Subjects

Izvēlieties iepirkumu grozu