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Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders [Mīkstie vāki]

(Professor Emerita, Department of Pediatrics and Human Genetics, College of Health Sciences, University of California, Irvine, CA, USA)
  • Formāts: Paperback / softback, 306 pages, height x width: 235x191 mm, weight: 660 g
  • Izdošanas datums: 29-Apr-2021
  • Izdevniecība: Academic Press Inc
  • ISBN-10: 0128219130
  • ISBN-13: 9780128219133
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  • Cena: 156,15 €
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Mechanisms and Genetics of Neurodevelopmental Cognitive DisordersPalielināt
  • Formāts: Paperback / softback, 306 pages, height x width: 235x191 mm, weight: 660 g
  • Izdošanas datums: 29-Apr-2021
  • Izdevniecība: Academic Press Inc
  • ISBN-10: 0128219130
  • ISBN-13: 9780128219133
Citas grāmatas par šo tēmu:
Permanent link: https://www.kriso.lv/db/9780128219133.html
Keywords:

Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders

connects neurodevelopment with genetics and behavior to better understand the underlying factors leading to cognitive neurodevelopmental disorders. This book focuses on mechanisms of disease and follows the development of specific brain regions, functions, and gene expression to causes and processes in autism, attention deficit disorder, and learning disabilities. Topics include brain mapping, brain plasticity, epigenetics, neuroimmunology, and many other factors that influence the development of these diseases.

This book will promote understanding of recent investigations and developments related to brain development from fetal life onward with specific relevance to neurodevelopmental cognitive disorders and conditions. This is an essential reference for anyone who is looking to learn more about different aspects of neurodevelopment and emerging concepts in psychiatric disorders.

  • Discusses links between brain development, gene expression, and brain function
  • Covers neural stem cells, proliferation, migration, differentiation, and neurogenesis
  • Includes brain mapping, brain plasticity, epigenetics, neuroimmunology, and more
  • Provides insight into causation and brain function in autism, attention deficit disorder, and learning disabilities
  • Examines impact of society and environmental factors on mental health
Acknowledgments xi
1 Brain, early development cortices, architecture, cell types, connectivity, networks
1 Early brain development
1(4)
2 Neuronal cell polarity microtubules centrosome and cytoskeleton
5(2)
3 Interneurons and their embryonic origins
7(1)
4 Astrocytes
8(1)
5 Neurotrophic factors in development and survival of neurons
9(1)
6 Microglia in brain health and disease
9(1)
7 Brain growth
10(2)
8 Interactions of brain with peripheral immune system
12(1)
9 Glia---neuron interactions in neuroendocrine system
13(1)
10 Specific brain regions and functions
14(3)
11 Genes with defects that lead to cortical malformations
17(1)
12 Mitochondrial function, neurogenesis, and neurodevelopment
17(1)
13 Transcriptomics and neuroscience
18(3)
References
18(3)
2 Neurotransmitters, neuromodulators, synapses
1 Neurons
21(6)
2 Brain membranes and neuronal functions
27(2)
3 Neurotransmitters and neuromodulators
29(9)
4 Noradrenergic system
38(3)
5 Neuromodulators and neuropeptides
41(8)
References
45(4)
3 Brain mapping
1 Introduction
49(1)
2 Normal brain and connectivity
49(2)
3 Brain morphometry to gather information on structure
51(5)
4 Developmental changes in connectivity
56(2)
5 Mapping sensory systems
58(2)
6 Vestibular system
60(2)
7 Speech
62(1)
8 Memory and cognition
63(1)
9 Central autonomic nervous system
64(2)
10 Brain mapping in psychiatric disorders
66(2)
11 Neurodevelopmental delay, intellectual disability, brain imaging
68(9)
References
72(5)
4 Brain plasticity
1 Evolution, synaptic activity, plasticity, and cognition
77(1)
2 Dendritic spines and neuroplasticity
78(1)
3 Memory, engram cells, and circuits
79(2)
4 Protein synthesis relevance to neuronal activity
81(2)
5 Alterations in synapses and postsynaptic regions in learning and memory
83(2)
6 Chromatin regulation and neuronal plasticity
85(1)
7 Glia and synaptic pruning
86(1)
8 Complement in the central nervous system
87(1)
9 Memory and engram
88(2)
10 Role of sleep in memory
90(1)
11 Molecular mechanisms of the memory trace
91(1)
12 AMPA glutamate receptors and synaptic plasticity
92(1)
13 Neuron and astrocyte energetics in memory and learning
92(1)
14 Environmental enrichment and brain plasticity
93(1)
15 Activity-dependent changes in myelin
94(1)
16 Cerebrovascular plasticity
95(4)
References
96(3)
5 Gene expression, regulation, and epigenetics in brain
1 Blueprint for development
99(1)
2 Evolution and brain development
100(3)
3 Regulation of gene expression and more recently analyzed genomic segments
103(2)
4 Signaling pathways and neural development
105(4)
5 Neuronal activity and epigenetics
109(3)
6 Additional insights into RNA functions and metabolism relevant to neuronal functions
112(1)
7 Environmental stimuli, gene transcription, and neural activity
112(10)
8 Additional insights gained into control of gene expression from studies on neurodevelopmental disorders
122(7)
References
124(5)
6 Neuroimmunology
1 Neural and hormonal influences and the immune system
129(2)
2 Microglia
131(1)
3 Central nervous system lymphatic system
132(1)
4 Complement
133(2)
5 Immune responses in the central nervous system
135(4)
References
137(2)
7 Neurodevelopmental, neurocognitive, and behavioral disorders
1 Introduction
139(1)
2 Neural tube defects and associated gene defects
139(1)
3 Brain growth and cortical expansion defects
140(1)
4 Specific brain defects due to abnormalities in products of ciliary pathway genes
141(2)
5 Defects in DNA replication and congenital microcephaly
143(1)
6 Corpus callosum intracerebral connectivity and defects
143(1)
7 Defects in cortex structural differentiation
144(3)
8 Intellectual disability
147(27)
9 Mitochondrial defects and impaired neurodevelopment
174(9)
10 Autism
183(4)
11 Attention deficit hyperactivity disorder
187(8)
References
188(7)
8 Epilepsy and movement disorders
1 Epileptic seizures and epilepsy
195(2)
2 Epilepsy classification
197(1)
3 Genetic factors in epilepsy
197(4)
4 Inborn errors of metabolism leading to seizures
201(1)
5 Genomic studies in epilepsies
202(1)
6 Epilepsy types associated with specific molecular defects
203(2)
7 Chromatin remodeling and transcriptional regulation factors and defects leading to epilepsy
205(1)
8 Cognitive impairment and association with epilepsy
205(1)
9 Neurodevelopmental disorders associated with movement abnormalities and/or cerebral palsy
206(1)
10 Cerebral palsy spectrum disorder
207(4)
11 Ataxias
211(1)
12 Neurodegeneration with brain iron accumulation
212(4)
13 Other abnormal movements that occur in specific disorders
216(9)
References
221(4)
9 Health and well-being
1 Health and well-being in the Anthropocene
225(1)
2 The Lancet one health commission report (2019)
226(1)
3 Promoting child health, child development, and child well-being
227(6)
4 Proposing solutions
233(2)
5 Aspects of positive psychology relevant to well-being
235(4)
References
236(3)
10 Brain and mind
1 Cognitive neuroscience
239(2)
2 Perception
241(1)
3 Memory systems
241(1)
4 Emotions
242(1)
5 Imagination
243(1)
6 Creative cognition and brain network dynamics
244(3)
7 Five different minds and the future
247(1)
8 Mind, ideas, and synthesis
248(5)
References
250(3)
11 Psychiatric disorders
1 Shared heritability of common disorders of the brain
253(1)
2 Architecture of psychiatric diseases
254(1)
3 Schizophrenia
255(6)
4 Psychiatric disorders, indications for involvement of different pathways
261(1)
5 Bipolar disorders
261(2)
6 Calcium ion channels and neuropsychiatric disorders
263(6)
References
265(4)
12 Neurodevelopmental disorders, diagnosis, mechanism discovery, and paths to clinical management
1 Patient evaluation
269(2)
2 Clinical value of a genetic diagnosis
271(1)
3 Diseases encompassed in the neurodevelopmental disorder category
272(10)
4 Peroxisomal disorders
282(2)
5 The mission of genomic medicine
284(3)
References
284(3)
Index 287
Dr. Moyra Smith is a Professor Emerita in the Department of Pediatrics and Human Genetics, College of Health Sciences, at the University of California, Irvine, and in past years has held appointments at the National Institutes of Health and Johns Hopkins University. In 2017, the UCI Emeriti Association awarded Dr. Smith the UCI Outstanding Emerita Award in recognition of her continuing research on genetics and genomics, strong record of publications, active engagement with programs in the Department of Pediatrics, mentoring of graduate students, and involvement with the CART Autism Center at UCI. Dr. Moyra Smith has published more than 100 scientific articles in peer-reviewed journals such as Frontiers in Molecular Biosciences, Molecular Psychiatry, the Journal of Medical Genetics (JMG), and Cytogenetics Cell Genetics.