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Medical Microbiology 2nd Revised edition [Mīkstie vāki]

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Edited by (Microbiology Department, Freeman Hospital, Newcastle Upon Tyne)
  • Formāts: Paperback / softback, 504 pages, height x width x depth: 243x190x20 mm, weight: 1053 g
  • Sērija : Fundamentals of Biomedical Science
  • Izdošanas datums: 13-Feb-2014
  • Izdevniecība: Oxford University Press
  • ISBN-10: 0199655138
  • ISBN-13: 9780199655137
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Medical Microbiology 2nd Revised editionPalielināt
  • Formāts: Paperback / softback, 504 pages, height x width x depth: 243x190x20 mm, weight: 1053 g
  • Sērija : Fundamentals of Biomedical Science
  • Izdošanas datums: 13-Feb-2014
  • Izdevniecība: Oxford University Press
  • ISBN-10: 0199655138
  • ISBN-13: 9780199655137
Citas grāmatas par šo tēmu:
Permanent link: https://www.kriso.lv/db/9780199655137.html
Biomedical scientists are the foundation of modern healthcare, from cancer screening to diagnosing HIV, from blood transfusion for surgery to food poisoning and infection control. Without biomedical scientists, the diagnosis of disease, the evaluation of the effectiveness of treatment, and research into the causes and cures of disease would not be possible.

The Fundamentals of Biomedical Science series has been written to reflect the challenges of practicing biomedical science today. It draws together essential basic science with insights into laboratory practice to show how an understanding of the biology of disease is coupled to the analytical approaches that lead to diagnosis. Assuming only a minimum of prior knowledge, the series reviews the full range of disciplines to which a Biomedical Scientist may be exposed - from microbiology to cytopathology to transfusion science.

The series: · Understands the complex roles of Biomedical Scientists in the modern practice of medicine. · Understands the development needs of employers and the Profession. · Addresses the need for understanding of a range of fundamental sciences in the context of Biomedicine. · Places the theoretical aspects of Biomedical Science in their practical context via clinical case studies.

The series is developed in partnership with and endorsed by the Institute of Biomedical Science. See ibms.org for more information.

Medical Microbiology covers a range of key laboratory techniques used in the diagnosis of important human diseases caused by microorganisms. From sample collection, through to analysis and laboratory investigation, the text covers a wide range of procedures and highlights how and why results are generated. The second edition has been expanded to cover a wider range of topics, and includes new chapters on parasitology, pathogenesis, and molecular diagnostics and investigation.

Online Resource Centre The Online Resource Centre to accompany Medical Microbiology features: For registered adopters of the book: · Figures from the book, available to download

For students: · An interactive Digital Microscope, encouraging the exploration of tissue samples · Video podcasts including interviews with practicing biomedical scientists, and 'in the lab' footage showing biomedical science in practice

Recenzijas

As a laboratory professional I would choose to recommend this text over others for those students wanting a career in laboratory medicine. * Dr Danilla Grando, RMIT University, Melbourne, Australia * Covers everything you need to know as a biomedical scientist right from the basic science of the types of microbes you may encounter to practical, safety and troubleshooting advice... The online interactive digital microscope is fantastic and I haven't seen anything like it before. I think it's a great way to get students excited about the subject and to be able to play with it in their own time to learn. * Reetika Suri, PhD Student, Queen Mary University of London *

An introduction to the Fundamentals of Biomedical Science series ix
Contributors xiii
Abbreviations xv
1 Introduction to microbiology 1(11)
Michael Ford
1.1 Classification
2(1)
1.2 The bacterial cell
2(2)
1.3 Bacterial growth
4(2)
1.4 Sterilization and disinfection
6(2)
1.5 Bacterial colony recognition
8(2)
Chapter Summary
10(1)
Further Reading
10(1)
Discussion Questions
11(1)
2 Identification tests 12(21)
John Perry
2.1 Biochemical tests
13(8)
2.2 Miscellaneous biochemical tests
21(3)
2.3 Carbon source utilization tests
24(1)
2.4 Susceptibility to antibiotics and chemical inhibitors
24(1)
2.5 Tolerance to environmental conditions
25(1)
2.6 Requirement for growth factors
25(1)
2.7 Identification schemes
26(1)
2.8 Commercial kits
27(1)
2.9 Automated systems
28(2)
2.10 Immunological tests
30(1)
2.11 Pitfalls and quality issues with biochemical identification tests
31(1)
Chapter Summary
31(1)
Further Reading
32(1)
Discussion Questions
32(1)
3 Culture media 33(19)
John Perry
3.1 Microbial requirements for growth
33(1)
3.2 Ingredients of culture media
34(3)
3.3 Selective media
37(1)
3.4 Differential media
38(2)
3.5 Enrichment media
40(1)
3.6 Chromogenic media
41(4)
3.7 Media for antimicrobial susceptibility testing
45(1)
3.8 Preparation and sterilization of culture media
46(2)
3.9 Quality control
48(2)
Chapter Summary
50(1)
Further Reading
50(1)
Discussion Questions
51(1)
4 Susceptibility testing and antibiotic assay 52(26)
Jenny Andrews
4.1 Rationale for antimicrobial susceptibility testing
53(1)
4.2 Commonly used antibiotics
53(1)
4.3 Antimicrobial susceptibility testing
54(6)
4.4 Broth methods
60(1)
4.5 Automated susceptibility testing
61(2)
4.6 Enzymatic methods of resistance (β-lactamases)
63(2)
4.7 Detection of mechanisms of resistance and the application of expert rules
65(2)
4.8 Additional tests
67(1)
4.9 Control of antimicrobial susceptibility testing
68(3)
4.10 Antibiotic assays
71(5)
Chapter Summary
76(1)
Further Reading
77(1)
Discussion Questions
77(1)
5 Blood cultures 78(27)
Derek Law
5.1 Laboratory investigation of blood culture samples
78(6)
5.2 Procedure for dealing with negative bottles
84(1)
5.3 Procedure for dealing with positive bottles
84(7)
5.4 Bacterial pathogens
91(4)
5.5 False-positive results
95(3)
5.6 Endocarditis
98(5)
Chapter Summary
103(1)
Further Reading
103(1)
Discussion Questions
104(1)
6 Investigation of urine samples 105(25)
Clive Graham
6.1 Overview of the urinary tract
106(2)
6.2 Urinary tract pathogens
108(5)
6.3 Urinary samples
113(1)
6.4 Transport of specimens to the laboratory
114(1)
6.5 Initial processing of samples
115(5)
6.6 Culture
120(6)
6.7 Urinary antibiotics
126(2)
Chapter Summary
128(1)
Further Reading
128(1)
Discussion Questions
129(1)
7 Investigation of wound, tissue, and genital samples 130(28)
Steve Davies
Mark Tovey
7.1 The skin and mucosa
131(1)
7.2 Skin infections and their causes
132(4)
7.3 Mucosal infections
136(3)
7.4 Organisms, virulence factors, and toxin production
139(4)
7.5 Sample processing
143(2)
7.6 Orthopaedic samples
145(1)
7.7 Genital tract and associated specimens
146(7)
7.8 Neisseria gonorrhoeae: virulence factors
153(1)
7.9 Sample processing
154(1)
7.10 Medicolegal issues
155(1)
Chapter Summary
156(1)
Further Reading
157(1)
Discussion Questions
157(1)
8 Examination of cerebrospinal fluid and fluids from sterile sites 158(25)
Derek Law
8.1 Investigation of cerebrospinal fluids
159(16)
8.2 Other sterile body fluids
175(6)
Chapter Summary
181(1)
Further Reading
182(1)
Discussion Questions
182(1)
9 Investigation of respiratory samples 183(33)
Louise Hill-King
9.1 The respiratory tract
183(6)
9.2 Processing of lower respiratory samples
189(10)
9.3 Cystic fibrosis
199(3)
9.4 Mycobacteria
202(8)
9.5 Hazardous organisms
210(4)
Chapter Summary
214(1)
Further Reading
215(1)
Discussion Questions
215(1)
10 Investigation of gastrointestinal specimens 216(28)
Michael Ford
Kathy Nye
10.1 The general principles of the investigation of gastrointestinal disease
217(3)
10.2 Bacterial pathogens associated with gastrointestinal disease
220(5)
10.3 Mechanisms involved in the production of disease by bacterial causes of intestinal infection
225(1)
10.4 Isolation media and how they work
226(3)
10.5 Identification of bacterial pathogens isolated from faeces samples
229(6)
10.6 Patient management and control of infection
235(1)
10.7 Therapeutic regimes
236(1)
10.8 Non-bacterial causes of gastrointestinal disease
236(4)
10.9 The role of the reference laboratory
240(2)
Chapter Summary
242(1)
Further Reading
242(1)
Discussion Questions
243(1)
11 Clinical parasitology 244(27)
Tony Worthington
11.1 What are parasites?
245(1)
11.2 Clinical parasitology in the twenty-first century
245(2)
11.3 Protozoa
247(6)
11.4 Helminths
253(5)
11.5 Cestodes (tapeworms)
258(4)
11.6 Diagnosis of gastrointestinal parasitic infections acquired through the gastrointestinal tract
262(1)
11.7 Examination of faeces for ova, cysts, and parasites (O,C,P)
263(4)
11.8 Immunological techniques
267(1)
11.9 Molecular techniques
267(1)
11.10 Treatment of parasitic infections acquired through the gastrointestinal tract
268(1)
Chapter Summary
269(1)
Further Reading
269(1)
Discussion Questions
270(1)
12 Infection prevention and control 271(24)
Sheila Morgan
Michael Ford
12.1 What is infection prevention and control?
272(1)
12.2 MRSA screening
272(6)
12.3 Vancomycin-resistant enterococci (VRE)
278(2)
12.4 Detection of pathogens that require initiation of a screening programme
280(1)
12.5 Importance of Clostridium difficile (C. difficile) in hospital environments
281(3)
12.6 Gram-negative outbreaks
284(1)
12.7 Other resistance screening and media
285(1)
12.8 Infection prevention and control
286(7)
Chapter Summary
293(1)
Further Reading
293(1)
Discussion Questions
294(1)
13 Laboratory investigations of viral infections 295(27)
Jayne Harwood
13.1 General properties and structure of viruses
296(2)
13.2 Viral pathogenesis
298(1)
13.3 Samples required for the diagnosis of viral infection
299(2)
13.4 Diagnostic methods in virology
301(5)
13.5 Serology
306(7)
13.6 Antiviral chemotherapy
313(1)
13.7 Common viral infections
314(6)
Chapter Summary
320(1)
Further Reading
321(1)
Discussion Questions
321(1)
14 Clinical mycology 322(32)
Derek Law
14.1 What are fungi?
322(2)
14.2 Clinical mycology in the twenty-first century
324(2)
14.3 Common fungal infections of man
326(1)
14.4 Infections of the skin, nails, and hair
327(9)
14.5 Candida infections of the mucosa
336(4)
14.6 Invasive fungal infections
340(9)
14.7 Antifungal susceptibility testing
349(2)
14.8 The role of the reference laboratory
351(1)
Chapter Summary
352(1)
Further Reading
352(1)
Discussion Questions
353(1)
15 Bacterial pathogenesis 354(39)
Lynn G. Dover
15.1 Fundamental themes
354(2)
15.2 Virulence factors
356(1)
15.3 Gaining a foothold - early events in infection
357(6)
15.4 Invasion by bacteria
363(7)
15.5 Avoiding the immune response
370(12)
15.6 Toxinogenesis
382(6)
15.7 Pan-genomes, mobile genetic elements, and the acquisition virulence factors
388(2)
Chapter Summary
390(1)
Further Reading
391(1)
Discussion Questions
392(1)
16 Molecular diagnostics 393(26)
Jayne Harwood
16.1 Polymerase chain reaction (PCR)
394(4)
16.2 Variations of PCR
398(4)
16.3 Advantages and disadvantages of PCR
402(1)
16.4 Applications
403(1)
16.5 DNA sequencing
404(3)
16.6 Molecular typing
407(2)
16.7 DNA microarrays
409(3)
16.8 Nucleic acid hybridization
412(5)
Chapter Summary
417(1)
Further Reading
418(1)
Discussion Questions
418(1)
17 Procedures for sample collection, transport, and processing 419(28)
Malcolm Holliday
17.1 The importance of sample collection
420(2)
17.2 Overview of different sample types and specimen containers
422(2)
17.3 Methods of sample collection
424(9)
17.4 Methods of sample transport
433(1)
17.5 Transport regulations
434(3)
17.6 Basic sample processing
437(1)
17.7 Inoculation of culture media
438(6)
17.8 Safety considerations
444(1)
Chapter Summary
445(1)
Further Reading
446(1)
Discussion Questions
446(1)
Hints and tips for discussion questions 447(4)
Self-check answers 451(9)
Glossary 460(11)
References 471(5)
Index 476
Dr Michael Ford has worked in Microbiology for over 20 years and has a wide experience in all areas of a diagnostic service. Michael was appointed Operational Services Manager for The Newcastle Upon Tyne Hospitals NHS Foundation Trust in 2003. His main research area is in bacterial identification, which has resulted in a number of publications, and two successful patents for the development of novel selective media. He has been a lecturer at Northumbria University for the past 12 years, and a member of the IBMS Scientific Advisory Panel for Microbiology since 2005. In 2007 Michael was appointed IBMS Deputy Chief Examiner.