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E-grāmata: Meiosis in Development and Disease

Volume editor (University of Texas, MD Anderson Cancer Center, TX, USA)
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Meiosis in Development and DiseasePalielināt
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Meiosis in Development and Disease, Volume 151 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as The initiation stages of meiosis, The molecular basis and dynamics of meiotic cohesions, and their significance in human infertility, Chromatin, recombination, and the centromeres, Sites and structures that mediate segregation when crossing over calls out sick/Life (or at Least Meiosis) Without Crossing Over, Crossover maturation inefficiency, Non coding RNA mediated gene regulation in meiosis, Short chromosomes in meiotic recombination, Chromatin level changes during meiosis initiation vs. oncogenesis, and much more.

Other sections of note include Chromosomal speciation revisited: Meiotic recombination and synapsis of evolutionary diverged homologs, Recombination suppression at specific chromosome regions, Unwinding during stressful times - mechanisms of helicases in meiotic recombination, Meiotic functions of PCH-2/TRIP13 and HORMADs, Crossover interference, Checkpoint control in meiotic prophase: Idiosyncratic demands require unique characteristics, The breadth of meiotic drive genes and mechanisms across the tree of life, and many more interesting topics.

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Current Topics in Developmental Biology series
  • Updated release includes the latest information on the Meiosis in Development and Disease
Contributors xi
Preface xv
1 Mechanism of initiation of meiosis in mouse germ cells
1(26)
Kei-Ichiro Ishiguro
1 Introduction
2(1)
2 STRA8 plays a key role in the initiation of meiosis
2(2)
3 MEIOSIN interacts with STRA8 during meiotic initiation
4(2)
4 MEIOSIN and STRA8 direct the switch from mitosis to meiosis
6(3)
5 MEIOSIN together with STRA8 determines meiotic entry
9(1)
6 MEIOSIN and STRA8 activate meiotic prophase program
10(3)
7 MEIOSIN and STRA8 boost the transcription of the meiotic genes
13(1)
8 Sexual difference of meiotic initiation
14(3)
9 Evolutionary conservation and divergence in the meiotic entry system
17(1)
10 Conclusion
18(1)
Acknowledgments
19(1)
Conflict of interest statement
19(1)
References
20(7)
2 Orchestrating recombination initiation in mice and men
27(16)
Elena Damm
Linda Odenthal-Hesse
1 Introduction---Orchestrating the critical stages of recombination initiation
28(1)
2 Germline replication timing affects broad-scale recombination patterning
28(1)
3 Chromatin loop array formation and loop extrusion
29(1)
4 Creating an accessible local chromatin environment
30(2)
5 Chromatin opening meiosis-specific Pioneer Complex
32(2)
6 Associate putative hotspot sites in the DNA loops with the chromosomal axis
34(1)
7 Facilitating efficient homology engagement and DSB repair
35(1)
8 PRDM9 redundant meiotic recombination initiation
36(1)
9 Summary
37(1)
References
38(5)
3 Cancer and meiotic gene expression: Two sides of the same coin?
43(26)
Ieng Fong Sou
Geert Hamer
Wee-Wei Tee
Gerben Vader
Urszula Lucja Mcclurg
1 Introduction
44(3)
2 Global DNA demethylation
47(2)
3 Histone modifications
49(2)
4 DNA accessibility
51(3)
5 Higher-order of chromatin structure
54(7)
6 Conclusions
61(1)
Acknowledgments
62(1)
Author contributions
62(1)
References
62(7)
4 Phase separation in controlling meiotic chromosome dynamics
69(22)
Ruirui Zhang
Yuanyuan Liu
Jinmin Gao
1 Chromosome dynamics during meiosis
70(2)
2 Phase separation to form biomolecular condensates in cells
72(3)
3 Phase separation in controlling chromatin organization and activities
75(1)
4 Phase separation in meiotic recombination initiation
76(1)
5 Phase separation in homologous chromosome pairing
77(4)
6 Phase separation in synapsis
81(2)
7 Potential phase separation in mammalian sex body formation
83(1)
8 Perspectives
84(2)
Acknowledgments
86(1)
References
86(5)
5 Meiotic chromosome organization and its role in recombination and cancer
91(36)
Chris Morgan
Aditya Nayak
Noriko Hosoya
Gerald R. Smith
Christophe Lambing
1 Chromatin and chromosome organization during meiosis
92(11)
2 Evolution of the core axis proteins and the synaptonemal complex
103(2)
3 Morphogenesis and remodeling of the chromosome axis
105(2)
4 Roles of chromosomal axis proteins in DSB and crossover formation during meiosis
107(2)
5 Does the chromosome axis play a role in CO interference?
109(3)
6 Temperature-based regulation of axis proteins and the impact on recombination
112(3)
7 Aberrant expression of the HORMADs and SC proteins regulates intrinsic DNA repair activities in somatic cancer cells
115(2)
Acknowledgments
117(1)
References
117(10)
6 Chromosome-specific behaviors during early meiosis
127(28)
Katherine Kretovich Billmyre
1 Introduction
128(1)
2 What is meiosis?
128(2)
3 How do chromosomes differ from each other?
130(2)
4 Association between meiotic errors and chromosome structure in humans
132(2)
5 Regulation of crossing over on different chromosomes
134(5)
6 Chromatin composition can influence multiple aspects of meiosis
139(2)
7 Aspects of chromosome biology that alter meiotic nuclear organization
141(3)
8 Other examples of chromosome-specific defects
144(1)
9 Summary
145(1)
Acknowledgments
145(1)
References
145(10)
7 Emerging mechanisms and roles of meiotic crossover repression at centromeres
155(36)
Sucharita Sen
Ananya Dodamani
Mridula Nambiar
1 Introduction
156(6)
2 The "centromere" effect
162(2)
3 Mechanisms of meiotic crossover repression at centromeres
164(1)
4 Saccharomyces cerevisiae
165(3)
5 Schizosaccharomyces pombe
168(1)
6 Caenorhabditis elegans
169(2)
7 Drosophila melanogaster
171(2)
8 Plants
173(1)
9 Mammals
174(4)
10 Pericentric crossovers and chromosomal mis-segregation
178(1)
11 Role of pericentric crossovers in human diseases
179(2)
12 Future perspectives
181(1)
Acknowledgment
182(1)
References
182(9)
8 Unwinding during stressful times: Mechanisms of helicases in meiotic recombination
191(26)
Magdalena Firlej
John R. Weir
1 Introduction
192(3)
2 Helicases and meiotic recombination
195(11)
3 Summary
206(1)
Acknowledgments
207(1)
References
207(10)
9 Meiotic crossover interference: Methods of analysis and mechanisms of action
217(28)
Yu-Chien Chuang
Gerald Ft. Smith
1 Introduction
218(2)
2 Methods for measuring crossover interference
220(4)
3 Complications in interpreting interference data
224(4)
4 Proteins required for crossover interference
228(3)
5 Models of crossover interference
231(6)
6 Conclusions and future research
237(1)
Acknowledgments
238(1)
References
238(6)
Further reading
244(1)
10 Small RNAs and their protein partners in animal meiosis
245(36)
Maria De Las Mercedes Carro
Andrew Grimson
Paula E. Cohen
1 Introduction
246(1)
2 RNA binding proteins in non-coding RNA pathways
247(7)
3 Roles for small RNAs and associated RBPs in the germline
254(2)
4 Meiotic silencing of unpaired chromatin
256(3)
5 Meiotic silencing of sex chromatin
259(2)
6 Pericentromeric heterochromatin remodeling during meiosis
261(3)
7 Regulation of meiotic recombination and double strand break repair
264(2)
8 Concluding remarks
266(2)
Acknowledgments
268(1)
References
269(12)
11 Checkpoint control in meiotic prophase: Idiosyncratic demands require unique characteristics
281(36)
Vivek B. Raina
Maud Schoot Uiterkamp
Gerben Vader
1 Mitotic and meiotic checkpoints
282(1)
2 Unique requirements of meiotic prophase
283(1)
3 The meiotic prophase checkpoint
284(6)
4 The logic of the spindle assembly checkpoint
290(4)
5 The meiotic prophase checkpoint: Logic and open questions in light of the SAC
294(5)
6 Meiotic checkpoint factors in cancer?
299(2)
Acknowledgments
301(1)
References
301(16)
12 PCH-2 and meiotic HORMADs: A module for evolutionary innovation in meiosis?
317(28)
Needhi Bhalla
1 Introduction
318(1)
2 The PCH-2/HORMAD module
319(2)
3 The role of meiotic HORMADs
321(2)
4 PCH-2/Pch2/PCH2/TRIP13 in meiosis
323(1)
5 Localization of PCH-2
324(2)
6 Role in pairing and synapsis
326(1)
7 Role in recombination
327(3)
8 Role in regulating meiotic progression
330(3)
9 Requirement for a cofactor
333(1)
10 A unified model of PCH-2's role in meiotic prophase
333(4)
11 Conclusion
337(1)
References
338(7)
13 In vitro spermatogenesis: Why meiotic checkpoints matter
345
Qijing Lei
Ans M.M. Van Pelt
Geert Hamer
1 Introduction
346(2)
2 Key meiotic events during meiosis
348(12)
3 Meiotic checkpoint mechanisms
360(3)
4 Prospects of in vitro spermatogenesis for research or clinical use
363(2)
Acknowledgments
365(1)
References
365
Francesca Cole, PhD., Associate Professor, CPRIT Scholar in Cancer Research, R. Lee Clark Fellow, University of Texas, MD Anderson Cancer Center, TX, USA
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