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E-grāmata: Metal Nanoparticles for Drug Delivery and Diagnostic Applications

Edited by (Professor, International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University, Karachi, Pakistan), Edited by (International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemi), Edited by
  • Formāts: PDF+DRM
  • Sērija : Micro & Nano Technologies
  • Izdošanas datums: 19-Oct-2019
  • Izdevniecība: Elsevier Science Publishing Co Inc
  • Valoda: eng
  • ISBN-13: 9780128169612
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Metal Nanoparticles for Drug Delivery and Diagnostic ApplicationsPalielināt
  • Formāts: PDF+DRM
  • Sērija : Micro & Nano Technologies
  • Izdošanas datums: 19-Oct-2019
  • Izdevniecība: Elsevier Science Publishing Co Inc
  • Valoda: eng
  • ISBN-13: 9780128169612
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Metal Nanoparticles for Drug Delivery and Diagnostic Applications addresses the lifecycle of metal nanoparticles, from synthesis and characterization, to applications in drug delivery and targeting. It is an important resource for those in biomaterials, nanomedicine and pharmaceutical sciences, exploring gold, silver and iron-based drug delivery systems for controlled and targeted delivery of potential drugs and genes for enhanced clinical efficacy. Nanotechnology is widely used in drug delivery due to its ability to reduce plasma fluctuation of drugs, high solubility, and efficiency, the relatively low cost of nanoscale products, and enhancement of patient comfort, hence this resource is a welcome edition to the science.

  • Illustrates the progression of nanoparticle therapeutics from basic research to applications
  • Explores new opportunities and ideas for developing and improving technologies in nanomedicine and nanobiology
  • Discusses the toxicity of different types of metal nanoparticles and how to ensure their safe use
List of contributors
xi
Preface xvii
1 Metal nanoparticles toxicity: role of physicochemical aspects
1(12)
Saeed Ahmad Khan
1.1 Introduction
1(1)
1.2 Mechanisms of metallic nanoparticles toxicity
2(1)
1.3 Effect of physicochemical properties on toxicity of metallic nanoparticles
3(6)
1.4 Conclusion
9(1)
References
9(4)
2 Erythrocytes modified (coated) gold nanoparticles for effective drug delivery
13(18)
Zul Kamal
Jing Su
Mingfeng Qiu
2.1 Introduction
13(1)
2.2 Nanotechnology and their advancement
14(1)
2.3 Nanosize passage from micro to nanoparticles
15(2)
2.4 Why modern therapeutics diverging to nanoscales?
17(1)
2.5 Nanomaterials and their exploded applications
17(1)
2.6 Metallic nanoparticles
18(1)
2.7 Cells based drug delivery system
18(2)
2.8 Blood cells based derived drug delivery system
20(1)
2.9 Gold nanoparticles
21(2)
2.10 Erythrocytes modified (coated) gold nanoparticles cargo
23(3)
2.11 Application of erythrocytes coated gold nanoparticles
26(1)
2.12 Conclusion
26(1)
References
27(4)
3 Biosynthesized metal nanoparticles as potential Alzheimer's disease therapeutics
31(12)
Muhammad Ayaz
Muhammad Ovais
Irshad Ahmad
Abdul Sadiq
Ali Talha Khalil
Farhat Ullah
3.1 Introduction
31(1)
3.2 Mechanisms and popular hypothesis of Alzheimer's disease
32(1)
3.3 Neurodegenerative disorders and status of Alzheimer's disease
33(1)
3.4 Epidemiology/prevalence, continent-based statistics of Alzheimer's disease
33(1)
3.5 Present therapeutic issues, concerns, disadvantages of Alzheimer's disease therapies
34(2)
3.6 Nanomedicines for Alzheimer's disease with specific reference to the metal nanoparticles
36(1)
3.7 Biogenic nanoparticles as promising Alzheimer's disease theranostic agents
37(2)
3.8 Conclusion and future prospects
39(1)
References
39(4)
4 Gold nanoparticles in cancer diagnosis and therapy
43(16)
Heyam Saad Ali
Babiker M. El-Haj
Salim Saifullah
Muhammad Kawish
4.1 Introduction
43(2)
4.2 Gold nanoparticles
45(1)
4.3 Gold nanoparticles in cancer therapy and diagnosis
46(6)
4.4 Gold nanoparticles in clinical trials
52(1)
4.5 Safety concerns of gold nanoparticles
52(1)
4.6 Conclusion
53(1)
References
53(6)
5 Gold nanorods: new generation drug delivery platform
59(26)
Saba Ishtiaq
Kifayat Ullah Shah
Tofeeq Ur-Rehman
Fakhar Ud-Din
5.1 Introduction
59(2)
5.2 Optical properties
61(1)
5.3 Synthesis
62(7)
5.4 Catalytic method
69(1)
5.5 Self-assembly of gold nanorods
69(2)
5.6 Gold nanorods applications in diagnostics
71(4)
5.7 Gold nanorod applications in drug delivery
75(4)
5.8 Conclusion
79(1)
References
80(5)
6 Surface engineered gold nanorods: intelligent delivery system for cancer therapy
85(14)
Syed Wadood Ali Shah
Mohammad Shoaib
Mehreen Ghias
Muhammad Naeem Ahmed
Abdul Hameed
Ismail Shah
6.1 Introduction
85(2)
6.2 Nanotechnology
87(7)
6.3 Conclusion
94(1)
References
95(4)
7 Role of gold- and silver-based nanoparticles in stem cells differentiation
99(20)
Sobia Ekram
Syeda Roohina Ali
Asmat Salim
Mujeeb-ur-Rehman
Irfan Khan
7.1 Introduction
99(1)
7.2 Effect on osteogenic differentiation
100(3)
7.3 Effect on chondrogenic differentiation
103(1)
7.4 Effect on adipogenic differentiation
104(1)
7.5 Role of nanoparticles in neuronal differentiation
105(1)
7.6 Role of nanoparticles in cardiac differentiation
105(1)
7.7 Effect on stem cells growth and proliferation
106(1)
7.8 Effect on reactive oxygen species
107(1)
7.9 Nanoparticles in wound healing
108(1)
7.10 Nanoparticles in cancer stem cells
109(2)
7.11 Cytotoxicity of nanoparticles on stem cells
111(1)
7.12 Conclusion
112(1)
References
112(7)
8 Nanosilver at the interface of biomedical applications, toxicology, and synthetic strategies
119(22)
Guotao Peng
Zil-e-Huma
Muhammad Umair
Irshad Hussain
Ibrahim Javed
8.1 Ag nanomaterials
120(3)
8.2 Synthetic strategies of silver nanomaterials
123(2)
8.3 Characterization
125(2)
8.4 Biomedical applications of silver nanomaterials
127(2)
8.5 Toxicology of silver nanomaterials
129(5)
8.6 Summary and future perspectives
134(1)
References
134(7)
9 Silver nanoparticles: a promising nanoplatform for targeted delivery of therapeutics and optimized therapeutic efficacy
141(34)
Zahid Hussain
Mohammed A.S. Abourehab
Shahzeb Khan
Hnin Ei Thu
9.1 Introduction
141(2)
9.2 Biomedical applications of silver nanoparticles
143(20)
9.3 Summary and future prospects
163(2)
Acknowledgment
165(1)
References
165(8)
Further reading
173(2)
10 Bactericidal potentials of silver nanoparticles: novel aspects against multidrug resistance bacteria
175(14)
Muhammad Kawish
Farhat Ullah
Heyam Saad Ali
Salim Saifullah
Imdad Ali
Jawadur Rehman
Muhammad Imran
10.1 Introduction
175(1)
10.2 Mechanisms for bacterial antibiotic resistance
176(1)
10.3 Silver nanoparticles
177(1)
10.4 Antibacterial spectrum of silver nanoparticles
178(1)
10.5 Antibacterial spectrum of silver nanoparticles against multidrug resistance bacteria
179(1)
10.6 Mechanisms of silver nanoparticles bactericidal activity
180(4)
10.7 Conclusion
184(1)
References
184(5)
11 Magnetic nanoparticles: drug delivery and bioimaging applications
189(26)
Salma Mirza
Malik Shoaib Ahmad
Muhammad Ishaq Ali Shah
Muhammad Ateeq
11.1 Introduction
189(4)
11.2 Synthesis of magnetic nanoparticles
193(4)
11.3 Drug delivery and bioimaging applications
197(10)
11.4 Conclusion
207(1)
References
208(7)
12 Surface functionalized magnetic nanoparticles for targeted cancer therapy and diagnosis
215(22)
Salim Saifullah
Imdad Ali
Muhammad Kawish
Rehan M. El-Shabasy
Lei Chen
Hesham R. El-Seedi
12.1 Introduction
216(1)
12.2 Considerations for magnetic nanoparticles design
217(3)
12.3 Functionalization of target specific magnetic nanoparticles
220(5)
12.4 Surface functionalization chemistry
225(3)
12.5 Magnetic nanoparticles targeting strategies and diagnosis
228(3)
12.6 Conclusion
231(1)
References
232(4)
Further reading
236(1)
13 Clinical implications of metals-based drug-delivery systems
237(22)
Talat Roome
Anam Razzak
13.1 Nanotechnology: an introduction
237(1)
13.2 Types of nanoparticles
238(5)
13.3 Biomedical applications of metal nanoparticles
243(8)
13.4 Drawbacks of nanoparticles in drug-delivery system
251(1)
13.5 Conclusion
252(1)
References
253(6)
14 pH-sensitive drug delivery systems
259(20)
Abdul Ghaffar
Basit Yameen
Muhammad Latif
Muhammad Imran Malik
14.1 Introduction
259(2)
14.2 Classification of pH-sensitive drug delivery systems
261(7)
14.3 Synthesis of pH-sensitive drug delivery systems
268(1)
14.4 Structure and architecture of pH-sensitive drug delivery systems
269(2)
14.5 Applications of pH-sensitive drug delivery systems at different levels
271(4)
14.6 Conclusion
275(1)
References
276(3)
15 Ionic liquid-based colloidal nanoparticles: applications in organic synthesis
279(22)
Marium Ishtiaq
Mariya al-Rashida
Rima D. Alharthy
Abdul Hameed
15.1 Introduction
280(2)
15.2 Classes of ionic liquids
282(4)
15.3 Nanoparticles
286(1)
15.4 Classification of nanoparticles
286(3)
15.5 Synthesis of nanoparticles
289(6)
15.6 Conclusion
295(1)
References
296(5)
16 Biomedical applications of magnetic nanoparticles
301(28)
Sana Rahim
Faiza Jan Iftikhar
Muhammad Imran Malik
16.1 Introduction
302(1)
16.2 Synthesis of magnetic nanoparticles
303(6)
16.3 Surface modification of magnetic nanoparticles
309(7)
16.4 Biomedical applications of magnetic nanoparticles
316(6)
16.5 Conclusion
322(1)
References
323(6)
Index 329
Muhammad Raza Shah is a full professor at the International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Pakistan. He is also the Head of the Center for Bioequivalence Studies and Clinical Research. He is a recipient of several awards, including the Tamgha-i-Imtiaz Award from the President of Pakistan, the Salam Prize, the Professor Atta ur Rahman Gold Medal, and the Dr M Raziuddin Siddiqi Prize, by the Pakistan Academy of Sciences, for scientists under 40 years of age, in the field of chemistry. Professor Shah has authored six books and edited four books, in addition to contributing over 350 peer-reviewed journal papers. One of his authored books was declared as best book of 2017 by the Government of Pakistans Higher Education Commission. Muhammad Imran is a graduate student and based at the International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University of Karachi, Pakistan. Shafi Ullah is a graduate student and based at the International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University of Karachi, Pakistan.
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