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E-grāmata: MicroRNA Cancer Regulation: Advanced Concepts, Bioinformatics and Systems Biology Tools

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This book discusses the role of microRNAs in the formation and progression of solid tumors. The main focus is on computational methods and applications, together with experimental techniques used to approach all aspects of microRNA regulation in cancer.

This edited reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and applications, together with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. We are sure that the emergence of high-throughput quantitative techniques will make this integrative approach absolutely necessary in the near future. This book will be a resource for researchers starting out with cancer microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology in cancer, and the state-of-the-art in computational microRNA biology.
1 MicroRNAs in Human Cancer
1(20)
Thalia A. Farazi
Jessica I. Hoell
Pavel Morozov
Thomas Tuschl
2 Bioinformatics, Non-coding RNAs and Its Possible Application in Personalized Medicine
21(18)
Simona Rossi
George A. Calin
3 MicroRNA Target Prediction and Validation
39(16)
William Ritchie
John E.J. Rasko
Stephane Flamant
4 MicroRNA-Regulated Networks: The Perfect Storm for Classical Molecular Biology, the Ideal Scenario for Systems Biology
55(22)
Julio Vera
Xin Lai
Ulf Schmitz
Olaf Wolkenhauer
5 The p53/microRNA Network in Cancer: Experimental and Bioinformatics Approaches
77(26)
Sabine Hunten
Helge Siemens
Markus Kaller
Heiko Hermeking
6 MicroRNAs in Melanoma Biology
103(18)
Manfred Kunz
7 MicroRNAs in the Lung
121(14)
Alexandra Sittka
Bernd Schmeck
8 The E2F1-miRNA Cancer Progression Network
135(14)
Susanne Knoll
Stephan Emmrich
Brigitte M. Putzer
9 Modeling microRNA-Transcription Factor Networks in Cancer
149(20)
Baltazar D. Aguda
10 Coordinated Networks of microRNAs and Transcription Factors with Evolutionary Perspectives
169(20)
Hisakazu Iwama
11 Mathematical Modeling of microRNA-Mediated Mechanisms of Translation Repression
189(36)
Andrei Zinovyev
Nadya Morozova
Alexander N. Gorban
Annick Harel-Belan
12 Web Resources for microRNA Research
225(26)
Ulf Schmitz
Olaf Wolkenhauer
13 Discovery of microRNA Regulatory Networks by Integrating Multidimensional High-Throughput Data
251(16)
Jian-Hua Yang
Liang-Hu Qu
14 Discovering Functional microRNA-mRNA Regulatory Modules in Heterogeneous Data
267(24)
Bing Liu
Lin Liu
Anna Tsykin
Gregory J. Goodall
Murray J. Cairns
Jiuyong Li
15 Elucidating the Role of microRNAs in Cancer Through Data Mining Techniques
291(26)
Luciano Cascione
Alfredo Ferro
Rosalba Giugno
Alessandro Lagana
Giuseppe Pigola
Alfredo Pulvirenti
Dario Veneziano
16 Working Together: Combinatorial Regulation by microRNAs
317(22)
Yitzhak Friedman
Ohad Balaga
Michal Linial
Index 339