E-grāmata: Microsystems for Enhanced Control of Cell Behavior: Fundamentals, Design and Manufacturing Strategies, Applications and Challenges

This handbook focuses on the entire development process of biomedical microsystems that promote special interactions with cells. Fundamentals of cell biology and mechanobiology are described as necessary preparatory input for design tasks. Advanced design, simulation, and micro/nanomanufacturing resources, whose combined use enables the development of biomedical microsystems capable of interacting at a cellular level, are covered in depth. A detailed series of chapters is then devoted to applications based on microsystems that offer enhanced cellular control, including microfluidic devices for diagnosis and therapy, cell-based sensors and actuators (smart biodevices), microstructured prostheses for improvement of biocompatibility, microstructured and microtextured cell culture matrices for promotion of cell growth and differentiation, electrophoretic microsystems for study of cell mechanics, microstructured and microtextured biodevices for study of cell adhesion and dynamics, and

biomimetic microsystems (including organs-on-chips), among others. Challenges relating to the development of reliable in vitro biomimetic microsystems, the design and manufacture of complex geometries, and biofabrication are also discussed.

Part I Fundamentals.- Introduction to microsystems in the biomedical field.- Some introductory notes on cell biology.- Some introductory notes on cell mechanics and mechanobiology.- Some introductory notes on engineering resources for interacting with cells.- II. Design and Manufacturing Strategies.- Overview of design and manufacturing strategies for biomedical microsystems.- Biomimetic computer-aided design: Addressing the complexity of biomaterials.- Multi-scale and multi-physics/chemistry modeling in biomedical microsystems.- Rapid prototyping of biomedical microsystems for interacting at a cellular level.- Nanomanufacturing for biomedical microsystems interacting at a molecular scale.- Characterization technologies for biomedical microsystems interacting with cells.- Issues linked to the mass-production of biomedical microsystems.- Part III Applications.- Overview of applications based on microsystems capable of interacting with cells.- Microfluidic devices for in vitro drug

screening and detection.- Microfluidic devices for enhanced disease diagnosis and modeling.- Cell-based sensors and related microsystems.- Cell-based actuators and related microsystems.- Microsystems for the study of cells subject to gradients of chemicals.- Electrophoretic microsystems for studying cell mechanics.- Microtextured and microstructured biodevices for studying cell adhesion and dynamics.- Microtextured and.- microstructured cell culture matrixes for controlling cell behavior.- Resonant microsystems for controlling cell growth and differentiation.- Microtextured and microstructured prostheses for enhanced biocompatibility.- Microsystems for the study of cell interactions within physiological structures.- Biomimetic microsystems inspired in complete organs and their structures.- Part IV Present Challenges and Future Proposals.- Towards reliable organs-on-chips and humans-on-chips.- Towards reliable biomanufacturing technologies.- Towards a systematic methodology for the

development of biomedical microdevices.- Project-based learning in the field of biomedical microdevices.