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E-grāmata: Microvascular Disease in Diabetes [Wiley Online]

Edited by Francesco Tecilazich

Formāts: 280 pages
Izdošanas datums: 22-Apr-2020
Izdevniecība: Wiley-Blackwell
ISBN-10: 1119309646
ISBN-13: 9781119309642

Citas grāmatas par šo tēmu:

Wiley Online
Cena: 203,65 €*
* this price gives unlimited concurrent access for unlimited time

Formāts: 280 pages
Izdošanas datums: 22-Apr-2020
Izdevniecība: Wiley-Blackwell
ISBN-10: 1119309646
ISBN-13: 9781119309642

Citas grāmatas par šo tēmu:

More info about Wiley Online

Rokasgrāmatas mājas lapa: https://onlinelibrary.wiley.com/doi/book/10.1002/9781119309642

Presents comprehensive coverage of the many microvascular complications of diabetes

Diabetes remains one of the main causes, in the western world, of legal blindness, end stage renal disease, and amputation, despite the implementation of tight glycemic control and the great progress in the management and care of our patients. This book provides a useful and handy tool to professionals and students in the field of diabetes and its microvascular complications by integrating information from clinical settings as well as from the frontlines of diabetic research. It provides readers with up-to-date diagnostic criteria, classifications, and therapeutic approaches. and recent discoveries on mechanisms of disease, experimental therapeutic agents, and biomarkers of disease. 

Written by top experts in the field, Microvascular Disease in Diabetes offers in-depth chapters covering pathophysiology; the genetics of diabetic microvascular disease; and the epigenetics of diabetic microvascular disease. It then provides sections featuring both clinical and research information on diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, and diabetic foot. It also looks at coronary microvascular dysfunction and cerebral microvascular disease.

Integrates new and accessible material on diabetic microvascular comorbidities
Covers all relevant microvascular systems
Provides a much-needed resource synthesizing research and clinical applications to treating microvascular complications of diabetes
Presents current diagnostic criteria, classifications, and therapeutic approaches, as well as recent discoveries on the mechanisms of disease, experimental therapeutic agents, and biomarkers of disease

Assembled in an easily consultable manner, Microvascular Disease in Diabetes is an excellent text for investigators, clinicians, and students looking to improve their understanding of diabetic complications.

Foreword to: Microvascular Disease in Diabetes

Editor Biography

xvii

List of Contributors

xix

1 Introduction

(4)

Andrea Giustina

Stefano Frara

References

(2)

2 Pathophysiology

(18)

Francesco Tecilazich

Introduction

(1)

Anatomo-Physiology of Microvessels

(1)

Regulation of Microvascular Tone

(2)

Endothelial-Dependent Vasodilation

(1)

Endothelial-Independent Vasodilation

(1)

Nerve Axon Reflex (NARV)

(1)

Myogenic Response

(1)

Functional Hyperemia

(1)

Venoarteriolar Response (VAR)

(1)

Structural Changes in the Microcirculation

(1)

Functional Changes in the Microcirculation

(8)

Endothelial Dysfunction

(1)

VSMC Dysfunction

(1)

NARV Impairment

(1)

Defective Myogenic Response

(1)

Reduced Functional Hyperemia

(1)

Endothelial Dysfunction

(1)

Role of the Immune System and Leukostasis

(1)

Role of Hyperglycemia

(3)

AGES

(1)

Polyol Pathway

(1)

Oxidative Stress

(1)

PKC

(1)

Transforming Growth Factor (TGF)-β

(1)

Hexosamine Pathway

(1)

PARP

(1)

ET-1

(1)

Vasoconstrictor Prostanoid Synthesis

(1)

Role of Insulin Resistance

(1)

Role of Inflammation

(1)

References

(7)

3 Genetics of Diabetic Microvascular Disease

(22)

Niina Sandholm

Carol Forsblom

Introduction

(1)

Genetics of DKD

(7)

Heritability of DKD

(1)

Candidate Genes for DKD

(1)

Linkage Studies for DKD

(1)

Genome-Wide Association Studies on DKD

(4)

Sequencing Efforts for DKD

(1)

Genetics of Diabetic Retinopathy

(3)

Heritability of Diabetic Retinopathy

(1)

Candidate Genes for Diabetic Retinopathy

(1)

Linkage Studies for Diabetic Retinopathy

(1)

GWAS on Diabetic Retinopathy

(2)

Sequencing Efforts for Diabetic Retinopathy

(1)

Genetics of Diabetic Neuropathy

(1)

Heritability of Diabetic Neuropathy

(1)

Candidate Genes for Diabetic Neuropathy

(1)

GWASs on Diabetic Neuropathy

(1)

Future Directions

(3)

Larger Studies Are Needed

(1)

How to Define the Phenotype?

(1)

Variability in the Phenotypic Definitions

(1)

Criteria for Controls

(1)

Do Genetics of Microvascular Complications in T1D and T2D Differ?

(1)

Low-Frequency and Rare Variants May Affect Diabetic Complications

(1)

Sequencing of Rare and Low-Frequency Variants

(1)

Linkage Analysis with GWAS Data

(1)

Genetics May Reveal Biology and Infer Causality

(1)

Conclusions

(1)

References

(8)

4 Epigenetics of Diabetic Microvascular Disease

(14)

Luciano Pirola

Diabetic Complications Include Microvascular and Macrovascular Injury

(1)

The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study in Type 1 Diabetic Patients, and the UKPDS Study in Type 2 Diabetic Patients, Support the Existence of the Hyperglycemic Memory Phenomenon

(1)

DCCT/EDIC Study

(1)

The UKPDS Study

(1)

Models of Hyperglycemic Memory

(1)

Animal Models

(1)

Cell Culture Models

(1)

The "Epigenetic Code"

(4)

DNA Methylation

(1)

Histone Methylation in Models of Hyperglycemic Variability

(1)

Epigenetic Changes in Microvascular Models of Glycemic Memory

(2)

miRNAs Contribute to the Control of Glucose Homeostasis and Are Dysregulated in Diabetes

(1)

Future Prospects

(2)

References

(5)

5 Diabetic Retinopathy - Clinical

(20)

Francesco Bandello

Rosangela Lattanzio

Alessandro Marchese

Emanuela Aragona

Introduction

(1)

Epidemiology

(1)

Screening

(1)

Risk Factors

(1)

Clinical Patterns

(8)

Non-Proliferative Diabetic Retinopathy (NPDR)

(4)

Clinical Findings

(2)

Diagnostic Tools

(1)

Treatment Strategies

(1)

Proliferative Diabetic Retinopathy (PDR)

(4)

Clinical Findings

(2)

Diagnostic Tools

(1)

Treatment Strategies

(2)

Diabetic Macular Edema (DME)

(4)

Classification

(31)

Clinical Findings

(1)

Diagnostic Tools

(1)

Treatment Strategies

(2)

Conclusions

(1)

References

(5)

6 Diabetic Retinopathy - Research

(6)

Gopalan Gnanaguru

Retina and Induction of Hyperglycemia

(1)

Hyperglycemia and Retinal Microvasculature

(1)

Hyperglycemia and Reactive Gliosis

(1)

Hyperglycemia and Neurodegeneration

(1)

Hyperglycemia and Inflammation

(1)

References

(3)

7 Diabetic Nephropathy - Clinical

(12)

Gianpaolo Zerbini

Epidemiology

(1)

Natural History

(1)

Stages of DN

(1)

Morphologic Changes

(1)

Pathophysiology

(1)

Clinical Course

(1)

Treatment

(1)

Primary Prevention

(1)

Secondary Prevention

(1)

Tertiary Prevention

(1)

Perspectives

(1)

References

(5)

8 Diabetic Nephropathy - Research

(14)

Silvia Maestroni

Gianpaolo Zerbini

Essential Hypertension and DN

(2)

Role of Genetics in the Pathogenesis of DN

(1)

Polyol Pathway and Non-Enzymatic Glycation

100

(1)

Environment

100

(1)

Perspectives

101

(1)

Sodium-Glucose Cotransporter-2 (SGLT2) and DN

101

(1)

B7-1 and DN

101

(1)

Animal Models

102

(1)

DN in Induced Model of Type 1 Diabetes Mellitus (T1DM)

102

(1)

DN in Spontaneous Model of T1DM

103

(1)

Ins2Akita Mice

103

(1)

Non-Obese Diabetic (NOD) Mice

104

(1)

OVE26 Friend leukemia virus B (FVB) Mice

104

(1)

DN in Spontaneous Models of T2DM

105

(1)

db/db Mice

105

(1)

References

105

(6)

9 Diabetic Neuropathy - Clinical

111

(18)

Christopher H. Gibbons

Introduction

111

(1)

Classification of Diabetic Neuropathies

111

(11)

Distal Symmetric Polyneuropathy (DSPN)

112

(2)

Diagnosis

113

(1)

Management

113

(1)

Small Fiber Neuropathy

114

(2)

Diagnosis

115

(1)

Management

115

(1)

Autonomic Neuropathy

116

(3)

Diagnosis

117

(1)

Management

117

(2)

Treatment-Induced Neuropathy of Diabetes (TIND)

119

(1)

Diagnosis

119

(1)

Management

120

(1)

Diabetic Radiculoplexopathy

120

(1)

Diagnosis

120

(1)

Management

121

(1)

Mononeuropathies

121

(1)

Diagnosis

121

(1)

Management

121

(1)

Cranial Neuropathies

121

(8)

Diagnosis

121

(1)

Management

122

(1)

Screening for Neuropathy

122

(1)

Summary of Management of Diabetic Neuropathy

122

(1)

References

123

(6)

10 Diabetic Neuropathy - Research

129

(28)

Krish Chandrasekaran

Lindsay A. Zilliox

James W. Russell

Basic and Translational Research in Diabetic Neuropathy

129

(17)

Animal Models of Diabetic Neuropathy

129

(2)

Basic Pathophysiology of Diabetic Neuropathy

131

(9)

Changes in Redox Potential

131

(2)

Role of Mitochondrial Dysfunction in Diabetic Neuropathy

133

(4)

Protein Kinase C (PKC) and Neuropathy

137

(1)

Advanced Glycation End Products

137

(1)

Modifying Molecular Chaperones

138

(1)

Inflammation and Neuropathy

138

(1)

TGF-β and Neuropathy

138

(1)

Metabotropic Glutamate Receptors (mGluRs) and Oxidative Injury

139

(1)

Growth Factors and Diabetes

139

(1)

Clinical Research in Diabetic Neuropathy

140

(18)

Treatment of Hypertension

141

(1)

Improved Glycemic Control

141

(1)

Diet and Lifestyle Interventions

142

(2)

Alpha-Lipoic Acid

144

(1)

Benfotiamine and Neuropathy

145

(1)

Treatment of Neuropathic Pain

145

(1)

Acknowledgments

146

(1)

References

147

(10)

11 Diabetic Foot - Clinical

157

(16)

Cristian Nicoletti

Introduction and Size of the Problem

157

(1)

Pathogenesis of Diabetic Foot Complications

158

(1)

Neuropathy

158

(1)

Peripheral Vascular Disease

158

(1)

Other Risk Factors

159

(1)

Prevention

159

(1)

Treatment

160

(1)

Treatment of Neuropathic Diabetic Foot Ulcers: Offloading

160

(1)

Treatment of PAD: Revascularization

161

(2)

Diabetic Foot Infections (DFIs)

163

(3)

Introduction

163

(1)

Diagnosis

163

(1)

Treatment

164

(2)

Wound Healing

166

(1)

Debridement

166

(1)

Dressings

167

(1)

Topical Negative Pressure Wound Therapy (NPWT)

167

(1)

E-grāmata: Microvascular Disease in Diabetes [Wiley Online]

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