This text covers the basic principles of mitochondrial dynamics in cardiovascular medicine, with particular emphasis on their functional roles in physiology and disease. The book will include articles pertaining to mitochondrial fitness on a global basis, providing therefore an update on the progress made in several aspects in the field. Thus, it will assist scientists and clinicians alike in furthering basic and translational research. Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.
Cardiac metabolic remodelling: hypoxia vs. failure .- Nitric Oxide and Mitochondrial Biogenesis .- Nitrite-nitric oxide signaling and cardioprotection .- Mitochondrial mutations in cardiac disorders .- Mitochondria and cardiac hypertrophy .- Functional implications of the clustering of cardiac mitochondria .- Mechanistic role of thioredoxin 2 in heart failure .- Mitochondrial bioenergetics during ischemia/reperfusion .- Peripheral blood mitochondrial DNA and myocardial function .- Mitochondria and angiogenesis .- Mitochondrial oxidative stress and atherosclerosis .- Apolipoproteins and mitochondrial function .- Mitochondria and glucose homeostasis .- Insulin resistance and mitochondrial dysfunction .- Mitochondria and cardiorenal syndrome .- Mitochondrial damage in kidney disease .- Prohibitin-2 and kidney function .- Mitochondrial heteroplasmy .- Mitochondrial transplantation.
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1 Functional Implications of Cardiac Mitochondria Clustering |
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1 | (24) |
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2 Mitochondrial Calcium Handling in Physiology and Disease |
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25 | (24) |
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3 The In Vivo Biology of the Mitochondrial Calcium Uniporter |
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49 | (16) |
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4 Mitochondrial Bioenergetics and Dysfunction in Failing Heart |
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65 | (16) |
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5 Mitochondrial Mutations in Cardiac Disorders |
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81 | (32) |
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6 Mitochondrial Function in Non-ischemic Heart Failure |
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113 | (14) |
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7 Mitochondria in Ischemic Heart Disease |
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127 | (14) |
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8 Mitochondrial Bioenergetics During Ischemia and Reperfusion |
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141 | (28) |
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9 Mechanistic Role of mPTP in Ischemia-Reperfusion Injury |
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169 | (22) |
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10 Functional Role of Mitochondria in Arrhythmogenesis |
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191 | (12) |
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11 Mitochondria and Cardiac Hypertrophy |
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203 | (24) |
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Heberty di Tarso Fernandes Facundo |
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Francisco Rodrigo de Lemos Caldas |
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12 Connexin 43 and Mitochondria in Cardiovascular Health and Disease |
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227 | (20) |
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13 Mitochondrial Mechanosensor Microdomains in Cardiovascular Disorders |
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247 | (18) |
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14 Mechanistic Role of Thioredoxin 2 in Heart Failure |
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265 | (12) |
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15 Mitochondria in Structural and Functional Cardiac Remodeling |
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277 | (30) |
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16 Functional Role of Nox4 in Autophagy |
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307 | (20) |
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17 Mitochondrial Ubiquitin Ligase in Cardiovascular Disorders |
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327 | (8) |
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18 Nitrite-Nitric Oxide Signaling and Cardioprotection |
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335 | (12) |
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19 Peripheral Blood Mitochondrial DNA and Myocardial Function |
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347 | (12) |
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20 Mitochondrial Proton Leak Plays a Critical Role in Pathogenesis of Cardiovascular Diseases |
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359 | (12) |
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21 Mitochondria and Angiogenesis |
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371 | (36) |
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22 High-Density Lipoprotein Regulation of Mitochondrial Function |
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407 | (24) |
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23 MitomiRs Keep the Heart Beating |
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431 | (20) |
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24 Mitochondrial Dysfunction in Cardiovascular Aging |
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451 | (14) |
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25 Insulin Resistance and Mitochondrial Dysfunction |
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465 | (56) |
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26 Mechanistic Role of Kinases in the Regulation of Mitochondrial Fitness |
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521 | (8) |
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27 Mitochondria Damage and Kidney Disease |
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529 | (24) |
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28 Mitochondrial Dysfunction in the Diabetic Kidney |
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553 | (10) |
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29 Prohibitin Signaling at the Kidney Filtration Barrier |
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563 | (14) |
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30 Mitochondrial Heteroplasmy |
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577 | (18) |
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31 Mitochondrial Transplantation in Myocardial Ischemia and Reperfusion Injury |
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595 | (26) |
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32 Mitochondria-Targeted Antioxidants for the Treatment of Cardiovascular Disorders |
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621 | |
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Dr. Gaetano Santulli received his MD and PhD at the University of Naples Federico II. A physician scientist, Dr. Santulli completed his postdoctoral training at Columbia University Medical Center in New York City, supported by an AHA fellowship and a Scientist Development Grant. Cardiologist, he authored more than 100 publications, including peer-reviewed articles in high impact journals, book chapters, and medical books. He is currently a faculty member of Columbia University. He lives in Manhattan.
Dr. Santullis expertise comprises both clinical and basic research topics, including hypertension, diabetes, angiogenesis, heart failure, arrhythmias, vascular disorders, and skeletal muscle disease. He is a member of several international academic societies, including New York Academy of Sciences, American Heart Association (AHA), American Diabetes Association, European Society of Cardiology, Endocrine Society, American Association for the Advancement of Science, European Association of Heart Failure, European Association of Echocardiography, Acute Cardiovascular Care Association, European Association of Percutaneous Cardiovascular Interventions. He serves on the Editorial Boards of numerous medical Journals
