This series provides researchers in the biological and medical sciences with timely reviews of selected areas in the molecular biology. Each volume is edited by an internationally recognised authority who selects authors and topics to provide a survey of current growth points in a specific field. "Molecular Aspects of Anticancer Drug - DNA Interactions" aims to be a definitive work in the cancer chemotherapy area replacing the editors' previous book on anti-cancer drug design which though still widely quoted as the "standard work", in the field has now become rather out of date. Such is the wealth of important new material generated by prominent workers in this area, that the publishers have found it necessary to split the text text into two volumes. Volume one was published several months ago.
DNA topoisomerases, K. Kohn and R. Ralph; the cellular and molecular
pharmacology of the anthrapyrazole antitumour agent, D.R. Newell and L.H.
Patterson; calicheamicin, G.A. Elistad and W.D. Ding; molecular pharmacology
of intercalator - groove binder hybrid molecules, C. Bailly and J.P.
Henichart; bleomycins - mechanism of polynucleotide recognition and oxidative
degradation, A. Natrajan and S.M. Hecht; kinetic analysis of drug-nucleic
acid binding modes - absolute rates and effects of salt concentration, W.D.
Wilson and F.A. Tanions; acridine-based anti-cancer drugs, W.A. Denny and
B.C. Baguley; the mitomycins - natural cross-linkers of DNA, M. Tomasz.
