| Preface |
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xv | |
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The Epidemiology of Basal Cell and Squamous Cell Carcinoma |
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1 | (9) |
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Incidence of Nonmelanoma Skin Cancer (NMSC) |
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1 | (2) |
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Trends in Incidence of BCC and SCC |
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3 | (1) |
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3 | (1) |
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Ultraviolet Radiation (UVR) |
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3 | (1) |
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4 | (1) |
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4 | (1) |
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4 | (1) |
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4 | (1) |
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5 | (1) |
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5 | (1) |
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5 | (1) |
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6 | (1) |
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History and Precursor Lesions |
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6 | (1) |
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Skin Cancer Prevention Strategies |
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6 | (4) |
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Histology of Epithelial Skin Tumors |
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10 | (8) |
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10 | (5) |
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15 | (1) |
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16 | (2) |
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UV Damage and DNA Repair in Basal Cell and Squamous Cell Carcinomas |
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18 | (13) |
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19 | (4) |
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UV-Induced Carcinogenesis in Squamous Cell Carcinoma (SCC) |
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23 | (2) |
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UV-Induced Carcinogenesis in Basal Cell Carcinoma (BCC) |
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25 | (6) |
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Papillomavirus Infections and Cancerogenesis of Squamous Cell and Basal Cell Carcinomas |
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31 | (12) |
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39 | (4) |
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The Immune System and Nonmelanoma Skin Cancers |
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43 | (6) |
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Epidemiologic Evidence from Organ Transplant Recipients |
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43 | (1) |
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Evidence from Studies on UV-Induced Immune Suppression and Nonmelanoma Cancer Formation |
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44 | (1) |
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Mechanisms Involved in Immune Suppression and Carcinogenesis of Nonmelanoma Skin Tumors |
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45 | (4) |
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Cytogenetics of Basal Cell Carcinoma and Squamous Cell Carcinomas |
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49 | (9) |
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49 | (1) |
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50 | (1) |
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Classical Karyotypic Analysis |
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51 | (1) |
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Fluorescence in Situ Hybridization Analysis and Comparative Genomic Hybridization Analysis |
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51 | (2) |
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Implications of Cytogenetic Findings and Future Developments |
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53 | (5) |
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The Hedgehog Signaling Pathway and Epithelial Skin Cancer |
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58 | (8) |
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The Hedgehog Signaling Pathway |
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59 | (1) |
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Alterations of Hedgehog Signaling in Skin Tumors |
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60 | (2) |
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Mouse Models for Basal Cell Carcinoma |
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62 | (1) |
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Novel Pathogenesis-Based Approaches for Prevention and Therapy of Basal Cell Carcinomas |
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63 | (3) |
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p53 Protein and Nonmelanoma Skin Cancer |
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66 | (14) |
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Honnavara N. Ananthaswamy |
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p53 Tumor Suppressor Gene |
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66 | (3) |
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Induction of p53 Protein by UV and Biologic Consequences |
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69 | (1) |
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A Model of UV-Induced Initiation and Progression of Squamous Cell Carcinomas |
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69 | (1) |
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p53 Mutations in Nonmelanoma Skin Cancers |
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69 | (3) |
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p53 Mutations in Mouse Skin Cancers |
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72 | (8) |
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TGF-β Pathway and Cancerogenesis of Epithelial Skin Tumors |
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80 | (14) |
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80 | (2) |
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Role of TGF-β in Epidermal Development |
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82 | (2) |
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Role of TGF-β in Epidermal Proliferation and Homeostasis |
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84 | (2) |
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Role of TGF-β in Epithelial Skin Cancer |
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86 | (8) |
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PDGF Pathways and Growth of Basal Cell and Squamous Cell Carcinomas |
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94 | (14) |
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Signal Transduction by PDGFs and Their Receptors |
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94 | (1) |
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In Vivo Functions of PDGFs and Their Receptors |
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95 | (2) |
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PDGF Alterations in Cancer |
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97 | (2) |
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The Role of PDGF for Cell Proliferation in BCCs |
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99 | (3) |
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The Role of PDGF/VEGF Signaling in Angiogenesis of SCCs |
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102 | (2) |
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PDGF Signaling in Dermatofibrosarcoma Protuberans and Giant Cell Fibroblastoma |
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104 | (1) |
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104 | (4) |
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Apoptosis and Cancerogenesis of Basal Cell and Squamous Cell Carcinoma |
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108 | (7) |
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Gene Mutations Lead to NMSCs |
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109 | (1) |
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Apoptosis Is Pivotal for the Removal of DNA Damaged and Transformed Cells |
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110 | (1) |
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UV-Light Changes the Expression Pattern of Apoptosis-Inducing and -Preventing Molecules in Skin Epidermis |
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110 | (1) |
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FasL, the Double-Edged Sword |
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111 | (1) |
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Downregulation of FasL on BCC by Antisense Oligonucleotides or Small Interfering RNAs (siRNAs) |
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112 | (1) |
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113 | (2) |
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The Role of Telomerase for Cancerogenesis of Basal Cell and Squamous Cell Carcinomas |
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115 | (20) |
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Interaction of Telomeres and Telomerase |
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116 | (3) |
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Telomerase Activating in Normal Skin |
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119 | (2) |
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Telomerase Activation in the Nonmelanoma Skin Tumors BCC and SCC and in Their Tumor-Free Margins |
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121 | (14) |
| Index |
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135 | |
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