In this book, clinicians and basic scientists from USA, India, and other countries focus on the rationales and clinical experiences with targeted approaches to treat, prevent, or manage cancer. Cancer is a hyperproliferative disorder that is regulated by multiple genes and multiple cell signaling pathways. Genomics, proteomics, and metabolomics have revealed that dysregulation of dozens of genes and their products occur in any given cell type that ultimately leads to cancer. These discoveries are providing unprecedented opportunities to tackle cancer by multi-faceted approaches that target these underpinnings. This book deals with a multi-targeted approach to treating cancer.
Targeting oncogenes. - Targeting cell death resistance. - Targeting replicative immortality. - Targeting angiogenesis. - Targeting invasion & metastasis. - Genome instability. - Targeting Inflammation. - Targeting energy metabolism. - Targeting tumor microenvironment.
