Interleukin-1 Mediated Immune Suppression and Resistance to Immunotherapy in Cancer summarizes the existing literature and discusses future perspectives about the role of IL-1 in immune suppression, cancer progression, angiogenesis, and resistance to immunotherapies. It also presents mechanisms to overcome IL-1 mediated immune suppression in tumor microenvironment.
The book covers topics about the source of IL-1 in the tumor microenvironment, IL-1 mediated downstream pathway, mechanism of IL-1 mediated immune suppression in cancer, and its effect on immunotherapy of cancer. Those topics help readers to understand the effect of IL-1 on cancer immunopathology and immunotherapy, and provide them with broader concepts to develop therapies for IL-1 enrichment tumors.
It is a valuable source for cancer researchers, clinicians and other members of biomedical field who wants to learn more about mechanisms to improve outcome of cancer immunotherapies.
- Presents a summary in the beginning of each chapter to help readers to find the needed information and understand the content easily
- Encompasses detailed schematic diagrams and illustrations throughout the content to explain the complex immune mechanisms discussed
- Discusses future perspectives in all chapters to motivate researchers to work on emerging problems
- Encloses contributions from internationally reknown experts sharing their experiences on clinics and research
1. Role of IL-1 gene polymorphisms in common solid cancers Ragini D. Singh, Sagar Dholariya, Anusmita Shekher, Avadhesh, Deepak Parchwani and Subash C. Gupta
2. The role of IL-1 in tumor growth and angiogenesis Kinjal Bhadresha, Pradeep K. Shukla and Pratibha Singh
3. Interleukin-1-mediated immune suppression and resistance to immunotherapy in cancer
4. Strategies to overcome interleukin-1-mediated immune suppression and resistance to immunotherapy in cancer Abhishek Puthenveetil, Shweta Dubey and Ankita Garg
5. Modulation of IL-1-mediated inflammation in cancer using a food-based approach: a preventive strategy Shubhi Singh, Smriti Gaur and Manisha Singh
6. IL-1-mediated inflammation in COVID-19 Preeti Jain, Baldeep Singh, Sadhna Aggarwal and Manisha Singh
7. Role of IL-1 in bacterial infections Aishwarya Rani and Devinder Toor
Manisha Singh, PhD, is a trained human and mouse immunologist and during the last 10 years, she has specialized in cancer immunology. The main focus of her work has been to increase the efficacy and understand the molecular mechanisms of various cancer immunotherapies. She is serving as the principal investigator on a 2-year grant ($545,486), having been funded by the US Department of Defense. Dr. Singh's current research is focused on understanding the role of inflammation in immune suppression and resistance to immunotherapy in cancer. Recently, she has submitted the NIH-R01 grant in which she proposed to study the role of IL-1 in immunotherapy induced resistance. She has published 24 peer-reviewed articles and many abstracts in prestigious journals such as Nature Communication, Journal of Immunology, and Journal of Clinical Investigator. Her work has been cited by several prestigious, peer-reviewed, international journals.
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