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Nanoengineered Biomaterials for Regenerative Medicine [Mīkstie vāki]

Edited by (Stern Family Profe), Edited by (Director of the Biomaterials and Advanced Drug Delivery Laboratory(bioAdd), Stanford University, USA), Edited by (Research Fellow, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Canada)
  • Formāts: Paperback / softback, 516 pages, height x width: 235x191 mm, weight: 1060 g
  • Sērija : Micro & Nano Technologies
  • Izdošanas datums: 20-Sep-2018
  • Izdevniecība: Elsevier Science Publishing Co Inc
  • ISBN-10: 0128133554
  • ISBN-13: 9780128133552
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Nanoengineered Biomaterials for Regenerative MedicinePalielināt
  • Formāts: Paperback / softback, 516 pages, height x width: 235x191 mm, weight: 1060 g
  • Sērija : Micro & Nano Technologies
  • Izdošanas datums: 20-Sep-2018
  • Izdevniecība: Elsevier Science Publishing Co Inc
  • ISBN-10: 0128133554
  • ISBN-13: 9780128133552
Citas grāmatas par šo tēmu:
Permanent link: https://www.kriso.lv/db/9780128133552.html
Keywords:

Nanoengineered Biomaterials for Regenerative Medicine showcases the advances that have taken place in recent years as an increasing number of nanoengineered biomaterials have been targeted to various organ tissues. The book systematically explores how nanoengineered biomaterials are used in different aspects of regenerative medicine, including bone regeneration, brain tissue reconstruction and kidney repair. It is a valuable reference resource for scientists working in biomaterials science who want to learn more about how nanoengineered materials are practically applied in regenerative medicine.

Nanoengineered biomaterials have gained particular focus due to their many advantages over conventional techniques for tissue repair. As a wide range of biomaterials and nanotechnology techniques have been examined for the regeneration of tissues, this book highlights the discussions and advancements made.

  • Provides a digestible reference source for surgeons and physicians who want to learn more on nanoengineered biomaterials and their use in effective medical treatments
  • Offers systematic coverage on how nanoengineered biomaterials are used for different types of medicine
  • Assesses the benefits and drawbacks of the use of bioengineered nanomaterials in different areas of regenerative medicine
Contributors xvii
Foreword xxiii
Preface xxv
Acknowledgement xxvii
Chapter 1 An introduction to nanoengineered biomaterials 1(12)
Masoud Mozafari
Jayakumar Rajadas
David L. Kaplan
1 Where Bio Meets Nano: Nanoengineered Biomaterials
1(1)
2 Nano-Bio Interfaces: Pushing the Boundaries
1(2)
3 Nanoengineered Biomaterials for Tissue Regeneration
3(1)
4 Physicochemical Features From Nanotechnology
4(3)
5 State-of-the-Art and Future Perspectives
7(2)
References
9(4)
Chapter 2 Nanoengineered biomaterials for bone/dental regeneration 13(26)
Saeid Kargozar
Peiman Brouki Milan
Francesco Baino
Masoud Mozafari
1 Introduction
13(1)
2 Structure and Function of Natural Tissue Needing Repair
14(3)
2.1 Bone Tissue
14(2)
2.2 Dental Tissue
16(1)
3 Repair Process
17(2)
3.1 Bone Repair
17(1)
3.2 Dental Repair
18(1)
4 Biomaterials for Bone/Dental Regeneration
19(6)
4.1 Natural Biomaterials
19(3)
4.2 Synthetic Biomaterials
22(3)
5 Nanoengineered Materials: Promises for Better Regeneration
25(3)
5.1 Nanoparticles/Nanospheres
25(1)
5.2 Nanofibers/Nanotubes
26(1)
5.3 Nanocomposites
26(2)
6 Conclusions and Outlook
28(1)
References
29(9)
Further Reading
38(1)
Chapter 3 Nanoengineered biomaterials for cartilage repair 39(34)
Farshid Sefat
Tehmeena Israr Raja
Muhammad Sohail Zafar
Zohaib Khurshid
Shariq Najeeb
Sana Zohaib
Ehsaneh Daghigh Ahmadi
Maryam Rahmati
Masoud Mozafari
1 Introduction
40(1)
2 Anatomy, Histology, and Physiology of Cartilage
41(4)
2.1 The Anatomy and Histology of Hyaline Cartilage
41(2)
2.2 The Anatomy and Histology of Fibrocartilage
43(1)
2.3 The Anatomy and Histology of Elastic Cartilage
43(1)
2.4 Physiology of Cartilage
44(1)
3 Cartilage Diseases
45(4)
3.1 Osteoarthritis
45(1)
3.2 Rheumatoid Arthritis
46(1)
3.3 Osteogenesis Imperfecta
46(1)
3.4 Osteochondrodysplasia
47(1)
3.5 Relapsing Polychondritis
47(1)
3.6 Osteochondritis
48(1)
3.7 Costochondritis
48(1)
3.8 Scleroderma
48(1)
3.9 Septic Arthritis
48(1)
3.10 Chondrosarcoma
49(1)
4 Common Treatments for Cartilage Repair
49(1)
5 The Role of Biomaterials in Cartilage Regeneration
50(4)
5.1 The Role of Natural-Based Biopolymers in Cartilage Regeneration
51(1)
5.2 The Role of Synthetic-Based Biopolymers in Cartilage Regeneration
52(2)
6 Scaffold Requirements for Cartilage Regeneration
54(2)
6.1 Scaffold Requirements
54(1)
6.2 The Architecture of Scaffold
54(1)
6.3 Biocompatibility
55(1)
6.4 Biodegradability
55(1)
6.5 Mechanical Properties
55(1)
6.6 Manufacturing Technologies
56(1)
7 Nanoengineering: New Trends for Cartilage Regeneration
56(5)
7.1 The Role of Photonics in Cartilage Regeneration
56(3)
7.2 Implementation of the Electrospinning Technique in Cartilage Regeneration
59(1)
7.3 Implementation of the Particulate Leaching Technique in Cartilage Regeneration
60(1)
7.4 Implementation of the Thermally Induced Phase Separation Technique in Cartilage Regeneration
60(1)
8 Major Limitations and Challenges in Cartilage Regeneration
61(1)
9 Conclusions
62(1)
References
62(11)
Chapter 4 Nanoengineered biomaterials for tendon/ligament regeneration 73(22)
J. Anjana
S. Deepthi
K.T. Shalumon
Ullas Mony
Jyh-Ping Chen
R. Jayakumar
1 Introduction
73(1)
2 The Basic Structure and Function of Tendon and Ligament Tissue
74(2)
2.1 Basic Structure and Mechanical Properties of Tendons
74(1)
2.2 Basic Structure and Mechanical Properties of Ligaments
75(1)
3 The Native Healing Mechanism and Current Clinical Interventions
76(3)
3.1 The Mechanism of Tissue Repair
76(2)
3.2 Current Clinical Interventions
78(1)
4 Tissue Engineering Approaches
79(1)
5 Nanoengineered Scaffolds for Tendon/Ligament Regeneration
80(7)
5.1 Fabrication of Nanofibers
80(1)
5.2 Nano-Based Systems for Tendon/Ligament Regeneration
81(6)
6 Conclusion
87(1)
7 Future Perspectives
87(1)
Acknowledgments
88(1)
References
88(5)
Further Reading
93(2)
Chapter 5 Nanoengineered biomaterials for cardiac regeneration 95(30)
Lucas Karperien
Ali Navaei
Brent Godau
Alireza Dolatshahi-Pirouz
Mohsen Akbari
Mehdi Nikkhah
1 Introduction
95(1)
2 Cardiac Tissue
96(5)
2.1 Anatomic Structure
96(1)
2.2 Cellular Composition
97(3)
2.3 Extracellular Matrix
100(1)
3 Nanoengineered Biomaterials for Cardiac Tissue Engineering and Regeneration
101(10)
3.1 Nanomaterials for Cardiac Regeneration
101(5)
3.2 Nanocomposite Biomaterials
106(5)
4 Nanopatterned Materials
111(5)
4.1 From Matter to Nanopatterns
111(1)
4.2 Mastering Cardiac Tissue Architecture Through Nanogeometry
112(4)
5 Conclusion
116(2)
References
118(6)
Further Reading
124(1)
Chapter 6 Nanoengineered biomaterials for vascular tissue engineering 125(20)
Pradeep Kumar
Lisa C. du Toit
Priyamvada Pradeep
Yahya E. Choonara
Viness Pillay
1 Introduction
125(1)
2 Electrospun Archetypes for Vascular Tissue Engineering
126(5)
2.1 Axially Aligned Nanofibrous Scaffolds
128(1)
2.2 Bilayered Electrospun Tubular Scaffolds
129(1)
2.3 Core-Shell Nanofibrous Meshes
130(1)
2.4 pDNA-CP Nanoparticles
130(1)
3 Cell Sheet Nano(bio)engineered Scaffolds
131(2)
4 Self-Assembled Nanofibrous Vascular Platforms
133(4)
4.1 Self-Assembling Peptides (SAPS)
133(2)
4.2 RGD-Peptide Functionalized Vascular Nanoplatforms
135(2)
5 Nanocomposites for Vascular Tissue Engineering
137(1)
6 Conclusions and Future Outlook
138(3)
Acknowledgment
141(1)
Conflict of Interest
141(1)
References
141(4)
Chapter 7 Nanoengineered biomaterial for brain tissue reconstruction and functional repairment 145(22)
Francisca S.Y. Wong
Ken K. Tsang
Amy C.Y. Lo
1 Introduction
145(1)
2 Brain Disorders and Current Treatment Options
146(5)
2.1 Acute Injuries
146(2)
2.2 Chronic Degenerative Diseases
148(2)
2.3 Brain Neoplasm
150(1)
3 Clinical Trials on Repairing and Regenerating the Brain
151(2)
3.1 NM Therapies for Brain Disorders in Clinical Trials
151(1)
3.2 Alternative Therapies for Acute Injuries and Chronic Degenerations in Clinical Trials
152(1)
4 NM-Mediated Gene Therapy
153(2)
4.1 DNA Delivery
154(1)
4.2 RNA Delivery
154(1)
4.3 NM Designs to Facilitate Delivery Across the BBB
155(1)
5 NM-Mediated Neural Tissue Engineering
155(3)
5.1 Functionalization of Nanomaterials
156(1)
5.2 In Situ Gelling Scaffolds
157(1)
6 Cells as Carriers for Local Delivery of NM
158(1)
7 Conclusions
159(1)
Acknowledgment
159(1)
References
159(8)
Chapter 8 Nanoengineered biomaterials for spinal cord regeneration 167(20)
R.C. Assuncao-Silva
E.D. Gomes
N.A. Silva
A.J. Salgado
1 Introduction
167(1)
2 Nanomaterials as Therapeutic Agent-Delivery Systems
168(6)
2.1 Nanoparticles
169(2)
2.2 Nanowires
171(1)
2.3 Micelles/Liposomes
172(2)
3 Nanomaterial-Guided Axonal Regeneration
174(5)
3.1 Electrospun Nanofibers
174(3)
3.2 Self-Assembly Nanofibers
177(1)
3.3 Nanotubes/Conduits
178(1)
4 Conclusions
179(1)
Acknowledgments
180(1)
References
180(7)
Chapter 9 Nanoengineered biomaterials for bridging gaps in damaged nerve tissue 187(28)
Smaranda Badea
Wutian Wu
1 Introduction
187(1)
2 Features of the Nervous System
188(3)
2.1 Central Nervous System
188(1)
2.2 Peripheral Nervous System
189(2)
3 Injuries Disconnecting the Nervous System
191(3)
3.1 Central Nervous System
191(1)
3.2 Peripheral Nervous System
191(1)
3.3 Classification and Considerations
192(2)
4 Nanomaterials for Bridging Gaps in Nervous Tissue
194(10)
4.1 Hydrogels
194(3)
4.2 Self-Assembling Scaffolds
197(4)
4.3 Electrospun Nanofibrous Scaffolds
201(2)
4.4 Carbon-Based Scaffolds
203(1)
5 Conclusions
204(1)
References
205(9)
Further Reading
214(1)
Chapter 10 Nanoengineered biomaterials for retinal repair 215(50)
Bhavika B. Patel
Anup D. Sharma
Najiba Mammadova
Elizabeth J. Sandquist
Metin Uz
Surya K. Mallapragada
Donald S. Sakaguchi
1 Retina Anatomy and Physiology
216(4)
1.1 Overview of Visual System and Cell Types of the Retina
217(3)
2 Diseases of the Retina
220(3)
2.1 Outer Retinal Diseases
220(2)
2.2 Inner Retinal and Optic Nerve Diseases
222(1)
3 Biomaterials and Therapeutic Strategies for Retinal Repair and Rescue Utilizing Nanoengineering
223(28)
3.1 Nanoparticulate Systems
224(15)
3.2 Liposomes, Niosomes, Dendrimers
239(2)
3.3 Nanoengineered Scaffolds
241(9)
3.4 Other Types of Scaffolds for Nanoengineering
250(1)
4 Translational Applications of Nanobased Systems for Ocular Diseases
251(1)
5 Conclusions and Future Directions
252(1)
Acknowledgments
253(1)
References
253(11)
Further Reading
264(1)
Chapter 11 Nanoengineered biomaterials for skin regeneration 265(20)
Peiman Brouki Milan
Saeid Kargozar
Mohammad Taghi Joghataie
Ali Samadikuchaksaraei
1 Introduction
265(1)
2 Wound Healing Cascade
266(1)
3 Biomaterials in Skin Regeneration
267(3)
3.1 Natural Biomaterials
268(2)
3.2 Synthetic Biomaterials
270(1)
4 Nanoengineered Biomaterials in Skin Regeneration
270(4)
4.1 Nanofibers for Skin Regeneration
271(1)
4.2 Nanoparticles for Skin Regeneration
272(2)
5 Other Nanotechnology-Based Strategies for Skin Regeneration
274(2)
6 Possible Risks of Nanomaterials for Human Health
276(1)
7 Concluding Remarks and Future Perspectives
276(1)
References
277(6)
Further Reading
283(2)
Chapter 12 Nanoengineered biomaterials for tracheal replacement 285(20)
Tehmeena Israr Raja
Masoud Mozafari
Peiman Brouki Milan
Ali Samadikuchaksaraei
Farshid Sefat
1 An Introduction to the Anatomy of the Trachea
285(1)
2 Diseases and Disorders Associated With the Trachea
286(1)
3 A Novel Requisite: Tissue Engineering and Nanomaterials
287(3)
4 Innovative Methods for Scaffold Manufacture
290(4)
4.1 Electrospinning
292(1)
4.2 Decellularization
292(1)
4.3 Three-Dimensional Printing
293(1)
4.4 Casting
294(1)
5 Nanotechnology for Synthetic Tracheal Reconstruction
294(3)
5.1 Incorporation of Stem Cells
296(1)
5.2 Importance of Endothelialization for Tracheal Implants
296(1)
6 Importance of Vascular Supply to Regenerative Tracheal Tissue
297(1)
7 Considerable Design Concepts and Nanoscale Optimizations for Synthetic Tracheas
298(1)
8 Concluding Remarks
299(1)
References
299(6)
Chapter 13 Nanoengineered biomaterials for lung regeneration 305(20)
Sina Mortarzadeh
Khosrow Mottaghy
Farshid Sefat
Ali Samadikuchaksaraei
Masoud Mozafari
1 Introduction
306(1)
2 Structure of the Lungs
307(1)
3 Different Lung Diseases
308(1)
4 Traditional Treatments for Lung Diseases
309(1)
5 The Role of Tissue Engineering and Biomaterials Approaches in Lung Regeneration
309(1)
6 The Role of Nanotechnological Approaches in Lung Regeneration
310(7)
6.1 The Role of Polymeric-Based Nanocarriers in Lung Regeneration
311(3)
6.2 The Role of SLN-Based Nanocarriers in Lung Regeneration
314(1)
6.3 The Role of Liposome-Based Nanocarriers in Lung Regeneration
315(1)
6.4 The Role of Metallic-Based Nanocarriers in Lung Regeneration
316(1)
7 Possible Risks of Nanomaterials Cytotoxicity
317(1)
8 Conclusions
317(1)
References
318(7)
Chapter 14 Nanoengineered biomaterials for kidney regeneration 325(20)
Tara Tariverdian
Payam Zarintaj
Peiman Brouki Milan
Mohammad Reza Saeb
Saeid Kargozar
Farshid Sefat
Ali Samadikuchaksaraei
Masoud Mozafari
1 Introduction
325(1)
2 Kidney Tissue
326(4)
2.1 Anatomic Structure
326(1)
2.2 Cellular Composition
326(4)
3 Nanotechnology for Kidney Regeneration
330(6)
3.1 Nanomaterials for Kidney Regeneration
330(6)
4 Nanotechnology in Artificial Kidney
336(2)
4.1 Artificial Kidney
336(1)
4.2 Artificial Kidney Systems
337(1)
4.3 Nanoporous Biomaterials for Artificial Kidney Systems
337(1)
5 Conclusions and Future Perspectives
338(1)
References
339(6)
Chapter 15 Nanoengineered biomaterials for diaphragm regeneration 345(18)
Tina Navaei
Peiman Brouki Milan
Hamid Reza Davari
Ali Samadikuchaksaraei
Masoud Mozafari
1 Introduction
345(2)
2 Diaphragm Anatomy
347(2)
2.1 Blood Supply
348(1)
2.2 Venous Drainage and Innervation
348(1)
2.3 Diaphragm Function
349(1)
3 Diaphragm Defects and Treatment
349(2)
3.1 Pathophysiology of (Congenital) Diaphragmatic Hernias
349(1)
3.2 Congenital Diaphragmatic Hernia (CDH) Reconstruction
349(2)
4 Tissue Engineering Solutions for Diaphragm Regeneration
351(1)
5 Nanoengineered Biomaterials for Possible Use in Diaphragm Regeneration
352(2)
5.1 Natural Polymers
352(1)
5.2 Synthetic Polymers
353(1)
6 Role of Nanoengineered Biomaterials in Diaphragm Regeneration
354(3)
7 Concluding Remarks and Future Perspectives
357(1)
References
357(5)
Further Reading
362(1)
Chapter 16 Nanoengineered biomaterials for intestine regeneration 363(16)
Aleksandra M. Urbanska
Farshid Sefat
Safiyya Yousaf
Saeid Kargozar
Peiman Brouki Milan
Masoud Mozafari
1 Introduction
363(3)
2 Structure and Function of Intestines
366(2)
2.1 Anatomic Structure of Intestines
366(1)
2.2 Cellular Composition
367(1)
3 Repair Process
368(1)
4 Stem Cell Therapy for Intestines
368(1)
5 Biomaterials for Intestinal Regeneration
369(2)
6 Tissue-Engineered Approaches for Regeneration of the Intestines
371(2)
6.1 The Intestinal Enteroid Culture System
371(2)
6.2 Harnessing the Inflammatory Response to Engineer Autologous Intestine
373(1)
7 Nanoengineered Biomaterials for Regeneration of the Intestines
373(2)
7.1 Nanomaterials
374(1)
7.2 Nanodevices
374(1)
7.3 Nanoparticles
374(1)
7.4 Application of Nanotechnology in Stem Cell Therapy
374(1)
7.5 Electrospinning
375(1)
8 Conclusions and Future Directions
375(1)
References
375(3)
Further Reading
378(1)
Chapter 17 Nanoengineered biomaterials for corneal regeneration 379(38)
Vanessa J. Wicklein
Bernhard B. Singer
Thomas Scheibel
Sahar Salehi
1 Introduction
379(7)
1.1 Anatomy and Functions of the Human Cornea
379(4)
1.2 Tissue Regeneration of Different Layers of the Cornea
383(3)
2 Materials for Cornea Regeneration
386(7)
2.1 Natural Polymers
386(5)
2.2 Synthetic Polymers
391(2)
3 Tissue Engineering Techniques and Scaffold Nanodesign
393(10)
3.1 Bottom-Up Approaches
393(3)
3.2 Top-Down Approaches
396(7)
4 Bio and Immuno Compatibility in Corneal Tissue Engineering
403(1)
5 Outlook and Future Perspectives
404(1)
Acknowledgment
405(1)
References
405(10)
Further Reading
415(2)
Chapter 18 Nanoengineered Biomaterials for the treatment of liver diseases 417(26)
Marti Ortega-Ribera
Jose Yeste
Rosa Villa
Jordi Gracia-Sancho
1 Introduction
417(3)
1.1 Liver Structure and Function
418(2)
1.2 Organ-on-a-Chip
420(1)
2 Liver-on-a-Chip (LoC)
420(10)
2.1 Microengineered Liver-on-a-Chip
421(5)
2.2 Key Factors and Microenvironment Elements
426(2)
2.3 ECM and Substrates
428(1)
2.4 Biomechanical Stimulation
428(1)
2.5 Hepatic Lobular Zonation
429(1)
2.6 Sensors
429(1)
3 Bioartificial Livers (BALs)
430(3)
3.1 Bioengineered Organs
430(1)
3.2 Cell Transplantation
431(1)
3.3 Artificial Liver
431(1)
3.4 Bioartificial Livers (BALs)
431(2)
4 Conclusions and Future Perspectives
433(1)
Acknowledgments
434(1)
References
434(9)
Chapter 19 Nanoengineered biomaterials for pancreas regeneration 443(16)
Dilem Ceren Oran
Ipek Simay Gokulu
Seda Kizilel
1 Introduction
443(1)
2 Biomaterials for Regenerative Medicine
444(1)
3 Nanoengineered Materials for Pancreas Regeneration
445(9)
3.1 Nanostructured Materials for Pancreas Regeneration
445(4)
3.2 Nanostructured Materials as Delivery Vehicles
449(2)
3.3 Nanostructured Materials for Visualization
451(3)
4 Conclusion
454(1)
References
454(5)
Chapter 20 Nanoengineered biomaterials for bladder regeneration 459(16)
Farshid Sefat
Tehmeena Israr Raja
Zoha Salehi Moghadam
Peiman Brouki Milan
Ali Samadikuchaksaraei
Masoud Mozafari
1 Introduction to the Anatomy and Physiology of the Bladder
459(2)
1.1 Urothe li um
459(1)
1.2 Lamina Propria
460(1)
1.3 Detrusor Muscle
460(1)
2 Bladder and the Need for Tissue Engineering
461(1)
2.1 Decellularized Scaffolds
461(1)
2.2 Synthetic Scaffolds
461(1)
3 Nanotechnology Meets Medicine
462(2)
4 Methods for Nanoscale Synthesis: Bottom-Up Versus Top-Down
464(2)
4.1 Bottom-Up Strategies
464(1)
4.2 Top-Down Strategies
464(2)
5 Applications of Nanotechnology in the Bladder
466(1)
6 Bladder Regeneration Through Nanotechnology
467(2)
6.1 Top-Down Processing of Nanoscale Scaffolds
467(1)
6.2 Combining Top-Down and Bottom-Up Processing of Nanoscale Scaffolds
467(1)
6.3 Bottom-Up Processing of Nanoscale Scaffolds
468(1)
7 Potential for Further Applications in Bladder Regeneration
469(1)
8 Conclusions
470(1)
References
470(5)
Index 475
Dr. Masoud Mozafari is a Fellow at Lunenfeld Tanenbaum Research Institute, Mount Sinai Health Hospital, University of Toronto. He was previously Assistant Professor and Director of the Bioengineering Lab, at the Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Cellular and Molecular Research Center, and Department of Tissue Engineering and Regenerative Medicine of the Iran University of Medical Sciences (IUMS), Tehran, Iran. Dr. Mozafaris research interests range across biomaterials, nanotechnology, and tissue engineering, and he is known for the development of strategies for the treatment of damaged tissues and organs, and controlling biological substances for targeted delivery into the human body. Dr. Mozafari has received several awards, including the Khwarizmi Award and the Julia Polak European Doctorate Award for outstanding translational research contributions to the field of biomaterials. He has also received the WIPO Medal for Inventors from The World Intellectual Property Organization (WIPO), in recognition of his contributions to economic and technological development. Dr. Mozafari is currently working on the editorial board of several journals. Jayakumar Rajadas is the founder and current Director of the Biomaterials and Advanced Drug Delivery Laboratory(bioAdd) at Stanford University, USA. This center has been involved in transforming biophysical ideas into biomaterial and drug delivery technologies. These technologies include microencapsulation of drugs, vascular grafts, bio-implants, development of small molecule and protein-based drugs, regeneration of nerve and cardiovascular tissues, and wound healing applications. Before moving to Stanford, he served as the founding chair of the Bio-organic and Neurochemistry Division at one of Indias national laboratories, Central Leather Research Institute Chennai, India, where he was responsible for both the organization and management of the division. Dr. Rajadas has published over 160 papers and has an h-index of 22. David L. Kaplan is Professor and Chair, Department of Biomedical Engineering, at Tufts University, USA. His research focus is on biopolymer engineering to understand structure-function relationships, with emphasis on studies related to self-assembly, biomaterials engineering and functional tissue engineering/regenerative medicine. He has published over 600 peer reviewed papers and edited eight books.