This book explores nanoparticles in cancer diagnosis and treatment, covering advanced detection methods, targeted therapies and innovative applications in radiotherapy and phototherapy. It addresses challenges, clinical trials and prospects making it a valuable resource for researchers, clinicians and students in oncology and nanotechnology.
This book comprehensively reviews the application of nanoparticles in cancer diagnosis and treatment. The introductory section provides a fundamental understanding of cancer biology, its global incidence and prevalence, and the intricate nano-bio interactions at the cellular level. The subsequent section discusses the pivotal role of nanoparticles in precise cancer detection, enhancing cancer imaging, and serving as contrast agents for accurate diagnosis. It also presents cutting-edge nanotechnology-based methods for detecting HTLV-1 retroviruses. The following section covers the utilization of lipid-based nanoparticles, monoclonal antibodies, and advanced nanotherapeutics for targeted cancer treatments. The chapters also explore polymeric nanoparticles for cancer vaccines, membrane-based nano-vaccines, and gene therapy approaches employing nanoparticles. The book further examines the application of nanotechnology in radiotherapy, phototherapy modalities, and strategies to overcome drug resistance. Additionally, it addresses chemodynamic nanoparticles for theranostics and the use of bioengineered virus-like nanoparticles in diagnostics and therapeutics. In the concluding sections, the book discusses the current status of anti-cancer nanotherapeutics in clinical trials and the challenges and future prospects of nanoparticle applications. This book is a useful resource for researchers, clinicians, and students in the fields of oncology and nanotechnology.
Part I: Introduction,
Chapter
1. An Introduction to Fundamentals of Cancer Cell Biology,
Chapter
2. Recent Patterns of Cancer Incidence and Mortality: Global and Indian Scenario,
Chapter
3. Nano-Bio Dynamics: Mechanisms and Challenges in Shaping Nanomaterials for Biomedical Use, Part II: Nanoparticles in Cancer Diagnosis,
Chapter
4. Conventional Methods of Cancer Diagnosis,
Chapter
5. Uncovering the Impact of Nanoparticles in Cancer Diagnosis,
Chapter
6. Nano Contrast Agents: Illuminating Cancer Pathways for Precise Diagnosis,
Chapter
7. Cancer Imaging Enhancement through Nanotechnology,
Chapter
8. Cancer Detection: Nanodevices at the Forefront of Early Diagnosis, Part III: Nanoparticles in Cancer Therapy,
Chapter
9. Conventional Methods of Cancer Therapy,
Chapter
10. Exploring the Nanoparticles in Cancer treatment,
Chapter
11. Lipid-based Nanoparticles to Diagnose and Cure Cancer,
Chapter
12. Multifunctional Nanomaterials for Advanced Cancer Therapy,
Chapter
13. Monoclonal Antibodies for Targeted Drug Delivery,
Chapter
14. Nanoparticles in Immunotherapy for Viral-Related Cancers,
Chapter
15. Sequential Catalytic Nanomedicine-enabled Chemotherapy-based Synergetic Cancer Treatments,
Chapter
16. Strategies Using Nanomedicine to Manage Drug Resistance in Cancer
Dr. Neelam Thakur has been serving as an Assistant Professor in the Department of Zoology at Sardar Patel University, Mandi, Himachal Pradesh, since the year 2022. She also holds the roles of Coordinator and Head of the Zoology Department at the same institution. Prior to her tenure at Sardar Patel University, she worked as an Associate Professor in the Department of Biosciences at Chandigarh University in Punjab. Dr. Thakur earned her Ph.D. in Genetics from Himachal Pradesh University in 2012. Following the completion of her Ph.D., she joined the Immunology lab at CSIR-Imtech, Chandigarh, as a Research Associate in 2012. Her research interests encompass various fields, including early diagnosis of tuberculosis and cancer, nanotechnology for cancer diagnostics and therapy, cytogenetic analysis of intellectually disabled individuals, and microbiome studies. She has a substantial research track record, having published more than 20 research papers in international journals of high repute. Additionally, she holds a patent titled Antigenic composition and method of expression thereof. Dr. Thakur has been recognized for her contributions to research with two Young Researchers Awards and one Eminent Researchers Award from government-registered societies and organizations.
Dr. Prudhvi Lal Bhukya is a Virologist currently serving as a Scientist at the ICMR-National Animal Resource Facility for Biomedical Research (NARFBR) in Hyderabad. Presently, he heads the Vaccine Testing Facility at NARFBR. His areas of expertise include preclinical vaccinology studies, host-viral interaction studies of emerging human viral infections, and the prevention and control of diseases, along with the development of tools to prevent outbreaks. He earned his Ph.D. from the ICMR-National Institute of Virology-Pune, focusing on the human hepatitis B virus. He has established his credentials through his work on HBV and HEV, as evidenced by his publication record. Dr. Bhukya has presented his research at numerous national and international conferences. His achievements include several publications in international journals of high repute.
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