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Primary Syntheses of 1,5-Naphthyridines |
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1 | (12) |
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From a Single Aliphatic Substrate |
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1 | (1) |
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From a Single Pyridine Substrate |
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2 | (3) |
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By Formation of the N1, C2-Bond |
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2 | (1) |
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By Formation of the C3, C4-Bond |
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3 | (1) |
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By Formation of the C4, C4a-Bond |
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4 | (1) |
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From a Pyridine Substrate with One Synthon |
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5 | (4) |
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Where the Synthon Supplies One Atom |
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5 | (1) |
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Where the Synthon Supplies Two Atoms |
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6 | (1) |
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Where the Synthon Supplies Three Atoms |
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7 | (2) |
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From a Pyridine Substrate and Two Synthons |
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9 | (1) |
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From Other Heterocyclic Substrates |
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10 | (3) |
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1,5-Naphthyridine, Alkyl-1,5-Naphthyridines, and Aryl-1,5-Naphthyridines |
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13 | (12) |
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13 | (6) |
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Preparation of 1,5-Naphthyridine |
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13 | (1) |
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Properties of 1,5-Naphthyridine |
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14 | (2) |
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Reactions of 1,5-Naphthyridine |
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16 | (3) |
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Alkyl- and Aryl-1,5-Naphthyridines |
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19 | (6) |
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Preparation of Alkyl- and Aryl-1,5-Naphthyridines |
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20 | (2) |
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Reactions of Alkyl- and Aryl-1,5-Naphthyridines |
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22 | (3) |
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Halogeno-1,5-Naphthyridines |
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25 | (18) |
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Preparation of Halogeno-1,5-Naphthyridines |
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25 | (6) |
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25 | (1) |
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By Halogenolysis of 1,5-Naphthyridinones or the Like |
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26 | (3) |
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By the Meissenheimer Reaction on 1,5-Naphthyridine N-Oxides |
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29 | (2) |
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By Miscellaneous Procedures |
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31 | (1) |
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Reactions of Halogeno-1,5-Naphthyridines |
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31 | (12) |
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Alcoholysis or Phenolysis of Halogeno-1, 5-Naphthyridines |
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31 | (3) |
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Aminolysis of Halogeno-1,5-Naphthyridines |
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34 | (4) |
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Other Reactions of Halogeno-1,5-Naphthyridines |
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38 | (5) |
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43 | (10) |
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Tautomeric 1,5-Naphthyridinones and Extranuclear Hydroxy-1,5-Naphthyridines |
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43 | (5) |
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Preparation of Tautomeric 1,5-Naphthyridinones and the Like |
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44 | (2) |
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Reactions of Tautomeric 1,5-Naphthyridinones and the Like |
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46 | (2) |
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Alkoxy- and Aryloxy-1,5-Naphthyridines |
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48 | (1) |
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Nontautomeric 1,5-Naphthyridinones |
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49 | (1) |
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1,5-Naphthyridine N-Oxides |
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50 | (3) |
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53 | (2) |
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Nitro-, Amino-, and Related 1,5-Naphthyridines |
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55 | (6) |
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55 | (2) |
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Preparation of Nitro-1,5-Naphthyridines |
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55 | (1) |
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Reactions of Nitro-1,5-Naphthyridines |
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56 | (1) |
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Amino- and (Substituted-Amino)-1,5-Naphthyridines |
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57 | (4) |
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Preparation of Amino-1,5-Naphthyridines |
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58 | (1) |
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Reactions of Amino-1,5-Naphthyridines |
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58 | (3) |
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1,5-Naphthyridinecarboxylic Acids and Related Derivatives |
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61 | (6) |
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1,5-Naphthyridinecarboxylic Acids |
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61 | (3) |
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1,5-Naphthyridinecarboxylic Esters |
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64 | (1) |
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1,5-Naphthyridinecarboxamides, Carbonitriles, Carbaldehydes, and Ketones |
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65 | (2) |
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Primary Syntheses of 1,6-Naphthyridines |
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67 | (24) |
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By Condensation of Two or More Aliphatic Substrates/Synthons |
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67 | (2) |
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From a Single Pyridine Substrate |
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69 | (6) |
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From a Pyridine Substrate with One Synthon |
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75 | (8) |
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Where the Synthon Supplies One Ring Atom |
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76 | (2) |
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Where the Synthon Supplies Two Ring Atoms |
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78 | (3) |
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Where the Synthon Supplies Three or More Ring Atoms |
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81 | (2) |
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From a Pyridine Substrate with Two or More Synthons |
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83 | (1) |
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From Other Heterocyclic Systems |
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84 | (7) |
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1,6-Naphthyridine, Alkyl-1,6-Naphthyridines, and Aryl-1,6-Naphthyridines |
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91 | (12) |
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91 | (6) |
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Preparation of 1,6-Naphthyridine |
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91 | (2) |
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Properties of 1,6-Naphthyridine |
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93 | (1) |
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Reactions of 1,6-Naphthyridines |
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94 | (3) |
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Alkyl- and Aryl-1,6-Naphthyridines |
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97 | (6) |
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Preparation of Alkyl- and Aryl-1,6-Naphthyridines |
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97 | (2) |
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Reactions of Alkyl- and Aryl-1,6-Naphthyridines |
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99 | (4) |
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Halogeno-1,6-Naphthyridines |
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103 | (12) |
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Preparation of Halogeno-1,6-Naphthyridines |
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103 | (5) |
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103 | (1) |
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By Halogenolysis of 1,6-Naphthyridinones or the Like |
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104 | (3) |
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107 | (1) |
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Reactions of Halogeno-1,6-Naphthyridines |
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108 | (7) |
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Alcoholysis or Phenolysis of Halogeno-1,6-Naphthyridines |
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108 | (2) |
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Aminolysis of Halogeno-1,6-Naphthyridines |
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110 | (1) |
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Dehalogenation of Halogeno-1,6-Naphthyridines |
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111 | (2) |
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Other Reactions of Halogeno-1,6-Naphthyridines |
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113 | (2) |
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115 | (10) |
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Tautomeric/Nontautomeric 1,6-Naphthyridinones and Extranuclear Hydroxy-1,6-Naphthyridines |
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115 | (5) |
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Preparation of 1,6-Naphthyridinones and the Like |
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116 | (2) |
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Reactions of 1,6-Naphthyridinones and the Like |
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118 | (2) |
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Alkoxy- and Acyloxy-1,6-Naphthyridines |
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120 | (1) |
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1,6-Naphthyridine N-Oxides |
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121 | (4) |
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125 | (2) |
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Nitro-, Amino-, and Related 1,6-Naphthyridines |
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127 | (8) |
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127 | (2) |
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Preparation of Nitro-1,6-Naphthyridines |
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127 | (1) |
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Reactions of Nitro-1,6-Naphthyridines |
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128 | (1) |
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Amino- and (Substituted-Amino)-1,6-Naphthyridines |
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129 | (6) |
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Preparation of Amino-1,6-Naphthyridines |
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130 | (1) |
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Reactions of Amino-1,6-Naphthyridines |
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131 | (4) |
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1,6-Naphthyridinecarboxylic Acids and Related Derivatives |
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135 | (8) |
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1,6-Naphthyridinecarboxylic Acids |
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135 | (4) |
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Preparation of 1,6-Naphthyridinecarboxylic Acids |
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135 | (2) |
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Reactions of 1,6-Naphthyridinecarboxylic Acids |
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137 | (2) |
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1,6-Naphthyridinecarboxylic Esters |
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139 | (1) |
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1,6-Naphthyridinecarboxamides |
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139 | (2) |
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1,6-Naphthyridinecarbonitriles, Carbaldehydes, and Ketones |
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141 | (2) |
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Primary Syntheses of 1,7-Naphthyridines |
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143 | (10) |
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From a Single Aliphatic Substrate |
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143 | (1) |
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From a Single Pyridine Substrate |
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143 | (4) |
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From a Pyridine Substrate with a Synthon |
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147 | (3) |
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From Other Heterocyclic Systems |
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150 | (3) |
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1,7-Naphthyridine, Alkyl-1,7-Naphthyridines, and Aryl-1,7-Naphthyridines |
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153 | (8) |
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153 | (4) |
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Preparation of 1,7-Naphthyridine |
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153 | (1) |
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Properties of 1,7-Naphthyridine |
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154 | (1) |
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Reactions of 1,7-Naphthyridine |
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155 | (2) |
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Alkyl- and Aryl-1,7-Naphthyridines |
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157 | (4) |
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Preparation of Alkyl- and Aryl-1,7-Naphthyridines |
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157 | (1) |
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Reactions of Alkyl- and Aryl-1,7-Naphthyridines |
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158 | (3) |
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Halogeno-1,7-Naphthyridines |
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161 | (6) |
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Preparation of Halogeno-1,7-Naphthyridines |
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161 | (2) |
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Reactions of Halogeno-1,7-Naphthyridines |
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163 | (4) |
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167 | (6) |
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167 | (3) |
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Preparation of 1,7-Naphthyridinones |
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167 | (1) |
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Reactions of 1,7-Naphthyridinones |
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168 | (2) |
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Alkoxy- and Acyloxy-1,7-Naphthyridines |
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170 | (1) |
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1,7-Naphthyridine N-Oxides |
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171 | (2) |
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173 | (2) |
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Nitro-, Amino-, and Related 1,7-Naphthyridines |
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175 | (4) |
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175 | (1) |
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176 | (3) |
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1,7-Naphthyridinecarboxylic Acids and Related Derivatives |
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179 | (4) |
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1,7-Naphthyridinecarboxylic Acids |
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179 | (3) |
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Preparation of 1,7-Naphthyridinecarboxylic Acids |
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179 | (1) |
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Reactions of 1,7-Naphthyridinecarboxylic Acids |
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180 | (2) |
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1,7-Naphthyridinecarboxylic Esters |
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182 | (1) |
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1,7-Naphthyridinecarboxamides |
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182 | (1) |
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1,7-Naphthyridinecarbonitriles |
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182 | (1) |
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1,7-Naphthyridinecarbaldehydes and Ketones |
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182 | (1) |
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Primary Syntheses of 1,8-Naphthyridines |
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183 | (14) |
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From an Aliphatic Substrate |
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183 | (1) |
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From a Single Pyridine Substrate |
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184 | (3) |
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From a Pyridine Substrate and Synthon(s) |
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187 | (5) |
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From Other Heterocyclic Substrates |
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192 | (5) |
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1,8-Naphthyridine, Alkyl-1,8-Naphthyridines, and Aryl-1,8-Naphthyridines |
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197 | (12) |
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1,8-Naphthyridine and Hydro Derivatives |
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197 | (6) |
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Preparation of 1,8-Naphthyridine |
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197 | (1) |
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Properties of 1,8-Naphthyridine |
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198 | (1) |
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1,8-Naphthyridine Complexes |
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199 | (1) |
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Reactions of 1,8-Naphthyridine |
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200 | (3) |
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Alkyl- and Aryl-1,8-Naphthyridines |
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203 | (6) |
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Preparation of Alkyl- and Aryl-1,8-Naphthyridines |
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203 | (2) |
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Reactions of Alkyl- and Aryl-1,8-Naphthyridines |
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205 | (4) |
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Halogeno-1,8-Naphthyridines |
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209 | (12) |
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Preparation of Halogeno-1,8-Naphthyridines |
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209 | (5) |
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Reactions of Halogeno-1,8-Naphthyridines |
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214 | (7) |
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221 | (10) |
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1,8-Naphthyridinones and the Like |
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221 | (6) |
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Preparation of 1,8-Naphthyridinones and the Like |
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221 | (3) |
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Reactions of 1,8-Naphthyridinones and the Like |
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224 | (3) |
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Alkoxy- and Aryloxy-1,8-Naphthyridines |
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227 | (1) |
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1,8-Naphthyridine N-Oxides |
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228 | (3) |
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231 | (4) |
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231 | (1) |
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Alkylthio-and Arylthio-1,8-Naphthyridines |
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232 | (1) |
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1,8-Naphthyridine Sulfoxides and Sulfones |
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232 | (1) |
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1,8-Naphthyridinesulfonic Acids and the Like |
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233 | (2) |
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Nitro-, Amino-, and Related 1,8-Naphthyridines |
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235 | (12) |
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235 | (3) |
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Preparation of Nitro-1,8-Naphthyridines |
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235 | (2) |
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Reactions of Nitro-1,8-Naphthyridines |
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237 | (1) |
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Nitroso-1,8-Naphthyridines |
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238 | (1) |
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238 | (9) |
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Preparation of Amino-1,8-Naphthyridines |
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238 | (3) |
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Reactions of Amino-1,8-Naphthyridines |
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241 | (6) |
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1,8-Naphthyridinecarboxylic Acids and Related Derivatives |
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247 | (14) |
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1,8-Naphthyridinecarboxylic Acids |
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247 | (4) |
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Preparation of 1,8-Naphthyridinecarboxylic Acids |
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247 | (2) |
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Reactions of 1,8-Naphthyridinecarboxylic Acids |
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249 | (2) |
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1,8-Naphthyridinecarbonyl Halides |
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251 | (1) |
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1,8-Naphthyridinecarboxylic Esters |
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252 | (2) |
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Preparation of 1,8-Naphthyridinecarboxylic Esters |
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252 | (1) |
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Reactions of 1,8-Naphthyridinecarboxylic Esters |
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252 | (2) |
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1,8-Naphthyridinecarboxamides |
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254 | (3) |
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Preparation of 1,8-Naphthyridinecarboxamides |
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254 | (1) |
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Reactions of 1,8-Naphthyridinecarboxamides |
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255 | (2) |
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1,8-Naphthyridinecarbonitriles |
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257 | (1) |
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1,8-Naphthyridinecarbaldehydes and Related Ketones |
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257 | (4) |
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Preparation of the Carbaldehydes and Ketones |
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257 | (2) |
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Reactions of the Carbaldehydes and Ketones |
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259 | (2) |
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261 | (14) |
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Primary Syntheses of 2,6-Naphthyridines |
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261 | (4) |
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2,6-Naphthyridines by Cyclization of Pyridine Derivatives |
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261 | (2) |
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2,6-Naphthyridines by Cyclocondensation of a Pyridine Derivative with a Synthon |
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263 | (1) |
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2,6-Naphthyridines from Other Heterocyclic Substrates |
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264 | (1) |
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2,6-Naphthyridine and Alkyl-2,6-Naphthyridines |
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265 | (2) |
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Preparation of 2,6-Naphthyridine |
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266 | (1) |
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Properties of 2,6-Naphthyridine |
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266 | (1) |
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Halogeno-2,6-Naphthyridines |
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267 | (2) |
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Preparation of Halogeno-2,6-Naphthyridines |
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267 | (1) |
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Reactions of Halogeno-2,6-Naphthyridines |
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268 | (1) |
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269 | (1) |
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270 | (1) |
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Nitro-, Amino-, and Related 2,6-Naphthyridines |
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271 | (1) |
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Preparation of Amino-2,6-Naphthyridines |
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271 | (1) |
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Reactions of Amino-2,6-Naphthyridines |
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272 | (1) |
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2,6-Naphthyridinecarboxylic Acids and Related Derivatives |
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272 | (3) |
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275 | (20) |
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Primary Syntheses of 2,7-Naphthyridines |
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275 | (8) |
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2,7-Naphthyridines from Nonheterocyclic Precursors |
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275 | (2) |
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2,7-Naphthyridines by Cyclization of Pyridine Substrates |
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277 | (1) |
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2,7-Naphthyridines by Cyclocondensation of Pyridine Substrates with Synthons |
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278 | (2) |
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2,7-Naphthyridines from Other Heterocyclic Substrates |
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280 | (3) |
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2,7-Naphthyridine and Alkyl-2,7-Naphthyridines |
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283 | (2) |
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Preparation of 2,7-Naphthyridine |
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283 | (1) |
|
Properties of 2,7-Naphthyridine |
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283 | (1) |
|
Reactions of 2,7-Naphthyridine |
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284 | (1) |
|
Halogeno-2,7-Naphthyridines |
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|
285 | (4) |
|
Preparation of Halogeno-2,7-Naphthyridines |
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286 | (1) |
|
Reactions of Halogeno-2,7-Naphthyridines |
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|
287 | (2) |
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|
289 | (1) |
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|
290 | (1) |
|
Nitro-, Amino-, and Related 2,7-Naphthyridines |
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290 | (1) |
|
2,7-Naphthyridinecarboxylic Acids and Related Derivatives |
|
|
291 | (4) |
|
2,7-Naphthyridinecarboxylic Acids |
|
|
291 | (1) |
|
2,7-Naphthyridinecarboxylic Esters |
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|
292 | (1) |
|
2,7-Naphthyridinecarboxamides and Carbonitriles |
|
|
293 | (1) |
|
2,7-Naphthyridinecarbaldehydes and Ketones |
|
|
293 | (2) |
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|
295 | (42) |
|
APPENDIX TABLES OF SIMPLE NAPHTHYRIDINES |
|
|
337 | (78) |
|
Table A.1 Alphabetical List of Simple 1,5-Naphthyridines |
|
|
339 | (9) |
|
Table A.2 Alphabetical List of Simple 1,6-Naphthyridines |
|
|
348 | (13) |
|
Table A.3 Alphabetical List of Simple 1,7-Naphthyridines |
|
|
361 | (5) |
|
Table A.4 Alphabetical List of Simple 1,8-Naphthyridines |
|
|
366 | (43) |
|
Table A.5 Alphabetical List of Simple 2,6-Naphthyridines |
|
|
409 | (2) |
|
Table A.6 Alphabetical List of Simple 2,7-Naphthyridines |
|
|
411 | (4) |
Index |
|
415 | |