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E-grāmata: Natural Polymer Drug Delivery Systems: Nanoparticles, Plants, and Algae

  • Formāts: PDF+DRM
  • Izdošanas datums: 23-Sep-2016
  • Izdevniecība: Springer International Publishing AG
  • Valoda: eng
  • ISBN-13: 9783319411293
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Natural Polymer Drug Delivery Systems: Nanoparticles, Plants, and AlgaePalielināt
  • Formāts: PDF+DRM
  • Izdošanas datums: 23-Sep-2016
  • Izdevniecība: Springer International Publishing AG
  • Valoda: eng
  • ISBN-13: 9783319411293
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This book describes 200 bio-polymers, including the most recent and advanced nanotechnology applications. The applications of various bio-medical and other future potential uses are covered and examined in depth. Systematic discussion of current leading natural polymers is also included.



 
1 Nanotechnology and Its Drug Delivery Applications
1(32)
1.1 Introduction
1(1)
1.2 Historical Prospects of Nanotechnology
2(1)
1.3 Promising Role in Drug Delivery
3(11)
1.3.1 Nanoparticles and Drug Delivery
8(1)
1.3.2 Use of NPs Formulation in Drug Delivery
9(2)
1.3.3 Cellular and Intracellular Targets
11(1)
1.3.4 The Brain---The Ultimate Target for Drug Delivery
12(2)
1.4 Innovations in Nanotechnology
14(2)
1.5 Nanotechnology Theory to Applications
16(3)
1.6 Nanomedicine/Nanoscience/Nano-Engineering and Relationship with Drug Delivery
19(4)
1.6.1 Nanomedicine and Drug Delivery
19(2)
1.6.2 Nanoengineering and Drug Delivery
21(2)
1.7 Types of Nanodelivery: Natural or Synthetic
23(1)
1.7.1 Synthetic Polymers
23(1)
1.7.2 Natural Polymers
23(1)
1.8 Natural and Synthetic Polymeric Nanoparticles
24(9)
2 Nanoparticles Types, Classification, Characterization, Fabrication Methods and Drug Delivery Applications
33(62)
2.1 Introduction
34(6)
2.2 Classification of Nanoparticles
40(1)
2.3 Characterization of Nanoparticles
40(4)
2.3.1 Particle Size
40(3)
2.3.2 Surface Charge
43(1)
2.3.3 Surface Hydrophobicity
44(1)
2.3.4 Drug Release
44(1)
2.4 Preparation of Nanoparticles
44(6)
2.4.1 Solvent Evaporation Method
45(1)
2.4.2 Spontaneous Emulsification or Solvent Diffusion Method
46(1)
2.4.3 Double Emulsion and Evaporation Method
46(1)
2.4.4 Salting Out Method
46(1)
2.4.5 Emulsions-Diffusion Method
47(1)
2.4.6 Solvent Displacement/Precipitation Method
48(1)
2.4.7 Coacervation or Ionic Gelation Method
48(1)
2.4.8 Polymerization Method
49(1)
2.4.9 Production of Nanoparticles Using Supercritical Fluid Technology
49(1)
2.5 Most Favorable Requirements for Designing Therapeutic Nanoparticles
50(1)
2.6 Types of Pharmaceutical Nanosystems
51(33)
2.6.1 Carbon Based Structures
51(2)
2.6.2 Fullerenes
53(1)
2.6.3 Quantum Dots
54(2)
2.6.4 Nanoshells
56(1)
2.6.5 Nanobubbles
57(1)
2.6.6 Paramagnetic Nanoparticles
58(1)
2.6.7 Nanosomes
59(1)
2.6.8 Pharmacyte
59(1)
2.6.9 Dendrimers
60(4)
2.6.10 Nanopores
64(1)
2.6.11 Microbivores
64(1)
2.6.12 Nanocrystals and Nanosuspension
65(1)
2.6.13 Solid Lipid Nanoparticles
65(1)
2.6.14 Silicon-Based Structures
66(1)
2.6.15 Metallic Nanoparticles
67(1)
2.6.16 Liposomes
67(1)
2.6.17 Polymeric Micelles
68(1)
2.6.18 Polymer Drug Conjugate
69(1)
2.6.19 Polyplexes/Lipopolyplexes
69(1)
2.6.20 Respirocytes
69(1)
2.6.21 Polymeric Nanoparticles
70(2)
2.6.22 Applications of Nanoparticulate Delivery Systems
72(1)
2.6.23 Passive Targeting
73(1)
2.6.24 Active Targeting
73(2)
2.6.25 Tumor Targeting Using Nanoparticulate Delivery Systems
75(1)
2.6.26 Long-Circulating and Target-Specific Nanoparticles
76(2)
2.6.27 Nanoparticles for Oral Delivery of Peptides and Proteins
78(1)
2.6.28 Nanoparticles for Gene Delivery
79(1)
2.6.29 Nanoparticles for Drug Delivery into the Brain
80(1)
2.6.30 Anthrax Vaccine Uses Nanoparticles to Produce Immunity
81(1)
2.6.31 Stem Cell Therapy
81(1)
2.6.32 Gold Nanoparticles Detect Cancer
82(2)
2.7 Hazards and Toxicity Profile of Nanoparticles
84(11)
2.7.1 Health Implication of Nanoparticles
84(11)
3 Natural Polymers vs Synthetic Polymer
95(24)
3.1 Bioengineered Materials: Nano-Engines of Drug Delivery Systems
95(1)
3.2 Polymeric Nanoparticles
96(1)
3.3 Contemporary Methodologies for Fabrication of Polymeric Nanoparticles
97(1)
3.4 Activation-Modulated Drug Delivery: Environmental Activation/Stimuli Responsive Smart Delivery System
98(2)
3.5 Time to Move on Innovative Methods of Administration
100(2)
3.6 History of Drug Delivery from the Ancient to Date
102(4)
3.6.1 Historical Role of Polymers as Plastics
105(1)
3.7 Shift from Nature to Synthetic (Including the Merits and Demerits of Synthetic Polymers)
106(8)
3.7.1 Natural Polymers and Synthetic Polymers for Scaffolds
109(1)
3.7.2 Natural vs Synthetic Polymer (as Biomaterial)
110(2)
3.7.3 Natural vs Synthetic Polymer in Tissue Engineering
112(1)
3.7.4 Natural vs Synthetic Polymer Hydrogels
113(1)
3.8 Natural Polymers (Reasons for Reverting to Nature)
114(5)
3.8.1 Need of Natural Polymers
115(1)
3.8.2 Disadvantages of Herbal Polymers
116(3)
4 Plant Derived Polymers, Properties, Modification & Applications
119(66)
4.1 Introduction
119(2)
4.2 Sources of Plant Polymers
121(3)
4.3 Methods of Extractions
124(2)
4.3.1 Cold Extraction
124(1)
4.3.2 Hot Extraction [ Mild Acidic (EHA), Alkaline (EHB) and Radical Hydrolysis (EHR)]
125(1)
4.3.3 Radical Hydrolysis (EHR)
125(1)
4.3.4 Microwave Assisted Extraction (EM)
125(1)
4.3.5 Ultrasonic Extraction (EU)
126(1)
4.3.6 Enzymatic Hydrolysis (EE)
126(1)
4.4 Chemical Composition Analysis
126(1)
4.5 Physical Properties
126(1)
4.5.1 Determination of Gelling Strength (GS)
126(1)
4.5.2 Determination of Gelling Temperature (GT) and Melting Temperature (MT)
126(1)
4.5.3 Viscosity Measurement (VS)
127(1)
4.5.4 Molecular Mass Determination (MM)
127(1)
4.6 Physical-Chemical Modification of Plant Based Natural Polymers (PBNPS)
127(16)
4.6.1 Chemical Modifications of Plant Based Natural Polymers (PBNPS)
128(6)
4.6.2 Procedure for the Development of Microfibrillated Plant Based Polymers (MPBPS) by Physical Modification
134(4)
4.6.3 Pre-treatment
138(1)
4.6.4 Post-treatments
139(1)
4.6.5 Dual Modifications
140(2)
4.6.6 Ozonation
142(1)
4.7 Genetic/Biotechnology Modification
143(1)
4.8 Applications of Plant Based Polysaccharides
144(41)
4.8.1 Cellulose
144(8)
4.8.2 Hemicellulose
152(1)
4.8.3 Starches
153(1)
4.8.4 Pectin
154(1)
4.8.5 Inulin
155(1)
4.8.6 Rosin
156(1)
4.8.7 Plant Based Gums
157(28)
5 Marine Polysaccharides Based Nano-Materials and Its Applications
185
5.1 Introduction
185(1)
5.2 Polysaccharides Derived from Marine Sources
186(9)
5.2.1 Marine Algae Based Polysaccharides
192(2)
5.2.2 Marine Crustaceans Derived Polysaccharides
194(1)
5.3 Nanomaterials Derived from Marine Sources
195(15)
5.3.1 Nano Scaffolds Derived from Fucoidan
195(2)
5.3.2 Alginate Nanoparticles
197(2)
5.3.3 Carrageenan Based Nanoparticles
199(3)
5.3.4 Agarose Nanoparticles
202(1)
5.3.5 Porphyran Based Nanoparticles
203(2)
5.3.6 Nanofibers of Ulvan
205(1)
5.3.7 Mauran Based Nanoparticles
205(1)
5.3.8 Chitin and Its Nanoparticles
206(1)
5.3.9 Chitosan Based Nanoparticles
206(4)
5.3.10 Chitooligosaccharide Based Nanoparticles
210(1)
5.4 Marine Polysaccharide-Based Nanomaterials and Its Biomedical and Biotechnological Applications
210(5)
5.4.1 Biomedical Applications of Marine Polysaccharides
211(3)
5.4.2 Role of Marine Based Polysaccharides for Biotechnological Applications
214(1)
5.5 Marine Polysaccharide-Based Nanomaterials and Its Patents
215
Saurabh Bhatia, PhD, is currently working as an Assistant Professor at the School of Medical and Allied sciences, GD Goenka University, Gurgaon, Haryana, India. He has several years of academic experience, teaching such specialized subjects as Natural product science, nanotechnology, biotechnology, parasitology, polymeric sciences, biomaterials. He has promoted several marine algae and their derived polymers throughout India. He has written more than 30 international publications in these areas and has been an active participant of more than 35 national and international conferences. So far he has successfully finished nine books in pharma and its allied sciences. His published books include Modern Applications of Plant Biotechnology in Pharmaceutical Sciences, Academic press, Elsevier, 2015; Nanotechnology in Drug Delivery: Fundamentals, Design, and Applications, Apple Academic Press 2016; Leishmaniasis: Biology, Control and New Approaches for Its Treatment, Apple Academic Press 2016; Natural polymer drug delivery systems: Nanoparticles, plants and algae, Springer, 2016, Natural polymer drug delivery systems: Nanoparticles, Mammals and microbes, Springer, 2016. Dr. Bhatia has graduated from Kurushetra University followed by M Pharm from Bharati Vidyapeeth University, Pune, India. He has received his PhD degree from Jadavpur University, Kolkata, India.
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