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E-grāmata: Necessity, Use, and Care of Laboratory Dogs at the U.S. Department of Veterans Affairs

  • Formāts: 170 pages
  • Izdošanas datums: 28-Sep-2020
  • Izdevniecība: National Academies Press
  • Valoda: eng
  • ISBN-13: 9780309676441
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  • Formāts: 170 pages
  • Izdošanas datums: 28-Sep-2020
  • Izdevniecība: National Academies Press
  • Valoda: eng
  • ISBN-13: 9780309676441

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For many years, laboratory dogs have served as important animal models for biomedical research that has advanced human health. Conducted at the request of the U.S. Department of Veterans Affairs (VA), this report assesses whether laboratory dogs are or will continue to be necessary for biomedical research related to the VA's mission. The report concludes that using laboratory dogs in research at the VA is scientifically necessary for only a few areas of current biomedical research. The report recommends that the VA adopt an expanded set of criteria for determining when it is scientifically necessary to use laboratory dogs in VA biomedical research; that the VA promote the development and use of alternatives to laboratory dogs; and highlights opportunities for the VA to enhance the welfare of laboratory dogs that are being used in biomedical research areas for which they have been deemed necessary.

Table of Contents



Front Matter Summary 1 Introduction 2 Legal, Social, and Ethical Considerations 3 Determining the Necessity of Laboratory Dogs in Biomedical Research Funded by or Conducted at the U.S. Department of Veterans Affairs 4 Alternatives to the Use of Laboratory Dogs 5 Care and Welfare of Laboratory Dogs Used in Biomedical Research Funded by or Conducted at the U.S. Department of Veterans Affairs Appendix A: Methods Appendix B: U.S. Department of Agriculture Statistics on the Use of Dogs and Other Animals in Research Appendix C: Biographical Sketches of Committee Members
Summary 1(12)
1 Introduction
13(10)
Origin of This Study
14(2)
Recent Legislation Concerning the Use of Laboratory Dogs at the VA
16(1)
Study Process
17(2)
The Committee's Interpretation of Its Task
19(1)
Terminology Used in This Report
19(1)
Organization of the Report
19(1)
References
20(3)
2 Legal, Social, And Ethical Considerations
23(16)
Historical Overview of Research Using Dogs
23(2)
Legal Context for Using Laboratory Dogs in Biomedical Research
25(4)
Standards for the Use and Welfare of Dogs in Biomedical Research
29(1)
Social and Ethical Considerations
29(1)
Ethical Considerations on the Use of Dogs in VA Research
30(5)
References
35(4)
3 Determining The Necessity Of Laboratory Dogs In Biomedical Research Funded By Or Conducted At The U.S. Department Of Veterans Affairs
39(50)
Trends in Dog Use in U.S. Research Facilities
40(1)
Laboratory Dog Use in Biomedical Research at the VA
41(18)
Next Steps for the Use of Laboratory Dogs in Biomedical Research Related to the VA's Mission
59(2)
The VA's Biomedical Research Review Process
61(3)
Operationalizing "Necessary" Areas of Agreement and Disagreement Within the Committee
64(6)
Opportunities to Improve Biomedical Research Protocols and Review Processes at the VA
70(2)
References
72(17)
4 Alternatives To The Use Of Laboratory Dogs
89(32)
Current Status of Alternatives Development
89(1)
Companion Dogs
90(4)
Other Animal Models
94(8)
Non-Animal Models: New Approach Methodologies
102(7)
Human Clinical Trials
109(1)
References
110(11)
5 Care And Welfare Of Laboratory Dogs Used In Biomedical Research Funded By Or Conducted At The U.S. Department Of Veterans Affairs
121(14)
Current Knowledge in the Science of Animal Welfare: A Brief Overview
121(3)
Additional Considerations for Enhancement of the Welfare of Laboratory Dogs
124(3)
Assessment of Current VA Practices: Do They Meet Current Standards, Requirements, and Recommendations with Regard to the Care and Welfare of Dogs?
127(2)
Considerations for Enhancement at the VA
129(1)
References
130(5)
Appendixes
A Methods 135(8)
B U.S. Department Of Agriculture Statistics On The Use Of Dogs And Other Animals In Research 143(6)
C Biographical Sketches Of Committee Members 149