Neurobiology of PTSD outlines the basic neural mechanisms that mediate complex responses and adaptations to psychological trauma, describing how these biological processes are impaired in individuals with posttraumatic stress disorder (PTSD). Throughout three comprehensive sections, expert authors present detailed analysis of the neural circuitry of emotion, biological findings in post-traumatic stress disorder, and neuroscience informed treatment and prevention. This book is a foundational resource for psychiatrists, neuroscientists, psychologists, and allied health professionals.
Contributors
Section 1 Neural Circuitry of Emotion
Introduction to Section 1
Israel Liberzon, Kerry Ressler
1. Behavioral Neuroscience of Circuits involved in Fear Processing
Elizabeth P. Bauer, Dennis Pare
2. Cellular Physiology of the Basolateral Complex of the Amygdala and its
Modulation by Stress
Brendan O'Flaherty, Chia Chun Hsu, Anzar Abbas, D.G. Rainnie
3. Generalizations of learned fear
Joseph E. Dunsmoor, Rony Paz
4. Neural circuits for context processing in aversive learning and memory
Stephen Maren
5. Adult hippocampal neurogenesis, generalization, and PTSD
Kristen C. Klemenhagen, Abby J. Fyer, H. Blair Simpson, René Hen
6. Behavioral Neuroscience of Circuits involved in Arousal Regulation
Arash Javanbakht, Gina R. Poe
7. Limbic Pathways to Stress Control: Regulation of the HPA Axis
James P. Herman
8. Prefrontal regulation of emotion
Annmarie MacNamara, K. Luan Phan, PhD
Section 2 Biological Findings in PTSD
Introduction to Section 2
Israel Liberzon, Kerry Ressler
9. Genetics of PTSD
Jennifer A. Sumner, Angela C. Bustamante, Karestan C. Koenen, Monica Uddin
10. Neurobiological pathways involved in fear, stress, and PTSD
Christine Heim, Charles B. Nemeroff
11. Inflammation and immune function in PTSD
Jennifer C. Felger, Ebrahim Haroon, Andrew H. Miller
12. Secondary messenger systems and other molecular pathways implicated in
PTSD
Ulrike Schmidt
13. Human Psychophysiology and PTSD
Tanja Jovanovic, Seth Davin Norrholm
14. Human fMRI in PTSD
Marie-France Mari, Mohammed R. Milad
15. Translational research from animal models to humans
Shigeru Morinobu, Shigeto Yamamoto, Manabu Fuchikami
Section 3 Neuroscience informed Intervention, Treatment, and Prevention
Introduction to Section 3
Israel Liberzon, Kerry Ressler
16. Mechanisms of action of psychotherapy
Sheila Rauch, Israel Liberzon
17. Mechanisms of action of medication treatment
Thomas D. Geracioti, Jeffrey R. Strawn, Matthew D. Wortman
18. Novel prevention, intervention, and treatment approaches
Jonathon R. Howlett, Murray B. Stein
Israel Liberzon is a Professor of Psychiatry, Psychology, and Neuroscience at the University of Michigan in Ann Arbor.
Kerry J. Ressler is a Professor of Psychiatry and Behavioral Sciences at Emory University School of Medicine.
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