This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.
1.How Immune-inflammatory processes link neurodegenerative and
psychiatric disorders.- 2.Gut-Microbiota-Brain Axis: pathophysiological
mechanism in neuropsychiatric disorders.- 3.Microbiome- induced autoimmunity
and novel therapeutic intervention.- 4.The key role of microlia and
circulating monocytes in etipathology neuropsychiatric disorders.-
5.Neuro-immuno-epigenetics of prenatal psychological stress.- 6.C-reactive
protein (CRP): a potent inflammation biomarker in psychiatric disorders.-
7.Neuroinflammation, neurognesis and neuroprotection in schizophrenia.-
8.Autoimmue psycosis: concept, clinical manifestation and management.-
9.Stress, autonomic nervous system and kynurenine pathway in major
depression.- 10.Brain-gut-microbiome axis in major depression : novel
therapeutic approach.- 11.Glial-Neuronal Interaction in Synapses: A Possible
Mechanism of the Pathophysiology of Bipolar Disorder.- 12.Neuroimmaging of
inflammation in depression and anxiety disorders.- 13.Neuroinflammationand
immune-kynureinine pathway in anxiety disorders.- 14.Inflammatory-mediated
responses in development of neurogeneartive diseases.- 15.The connection
between gut-brain axis and PTSD.- 16.Eating disorders : Gut
microbiota-immune-brain interactions.- 17.Sleep-immune crosstalk and sleep
disorders.- 18.Obsessive-compulsive disorder: immuno-inflammatory disorder?.-
19.Cytokine, neuroinflammation and neurodeneration in Alzheimers disease.-
20.Molecular imaging of neuroinflammation in Alzheimer's disease and MCI.-
21.The role of N-Methyl-D-Aspartate Receptor Neurotransmission and mictobiota
in Alzheimers disease.- 22.Neuroglial activation and neuroinflammation in
the brain of patients with autism.- 23.Suicide and inflammation.-
24.Anti-inflammatory effect of Traditional Chinese Medicine on the concept
of Mind-body interface.- 25.Anti-inflammatory therapy as a promising target
in neupsychiatric disorders.
Yong-Ku Kim, MD, PhD is a Professor of Psychiatry at College of Medicine, Korea University. He received a MD degree from College of Medicine, Korea University in 1987 and a PHD in psychiatry from Korea University in 1998. Dr. Kim has been affiliated with Korea University since 1998, first as an assistant professor (1998-2000), then as associated professor (2001-2005), professor (2006- present). For the past 20 years, his professional activities have extended beyond the area of pure clinical or research work. Dr. Kim has well over 200 publications in peer-reviewed international journals, including Biological Psychiatry, Molecular Psychiatry, Clinical Journal of Psychiatry, and Progress in Neuropsychopharmacology and Biological Psychiatry and 30 publications of book chapters and have made over 90 academic presentations in my area of interest. Dr. Kim is a fellow of Collogicum Internationale Neuropsychopharmacologicum, International Society for Affective Disorders, World Federation of theSociety of biological Psychiatry. He currently sits on the editorial boards of some leading academic journals in the field of neurobiology, including Progress in Neuropsychopharmacology and Biological Psychiatry, Psychiatry Investigation, World Journal Psychiatry, Annals of Depression and Anxiety, Psychiatry Journal and so on. Dr. Kim received prestigious awards such as Astrageneca Award and Dr. Paul Janssen Schizophrenia Research Award. Dr. Kim is currently the president of Korean society of Biological Psychiatry (2016-present).
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