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E-grāmata: Neurology of Aids 3rd Revised edition [Oxford Medicine Online E-books]

Edited by (Professor and Chair, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE), Edited by , Edited by , Edited by , Edited by , Edited by (Distinguished Professor of Psychiatry , Director, HIV Neurobehavioral Research Program, University of Ca), Edited by
  • Formāts: 1160 pages, 205 illustrations
  • Izdošanas datums: 08-Dec-2011
  • Izdevniecība: Oxford University Press Inc
  • ISBN-13: 9780195399349
  • Oxford Medicine Online E-books
  • Cena pašlaik nav zināma
  • Formāts: 1160 pages, 205 illustrations
  • Izdošanas datums: 08-Dec-2011
  • Izdevniecība: Oxford University Press Inc
  • ISBN-13: 9780195399349
Neurological complications of progressive HIV-1 infection remain a common cause of morbidity even during widespread use of antiretroviral therapy (ART). Long-term resistance to ART, drug compliance, untoward drug side effects, a myriad of opportunistic infection, depression and other psychiatric disease manifestations, concomitant drug abuse, neuropathies, and an inability to clear viral reservoirs, explain, in large measure, disease progression and immune deterioration. These are associated with a number of psychiatric, muscle, nerve, infectious, as well as cognitive, behavioral, and motor disturbances seen in infected people.

Fully updated from the previous two editions and replete with color images, The Neurology of AIDS, Third Edition covers each of these neurological complications and more with a focus on molecular and viral disease processes, cellular factors influencing viral replication therapeutic challenges, and the changing epidemiological patterns of disease. From basic science to clinical care, to epidemiological disease patters, The Neurology of AIDS is the only complete textbook available on AIDS neurology and the only one comprehensive enough to stand alone in each segment of study in brain disorders affected by the human immunodeficiency virus. It is an indispensable resource for students, resident physicians, practicing physicians, and for researchers and experts in the HIV/AIDS field.
Contributors xix
Interactive Topical Discussion on AIDS Neurology: Past, Present, and Future xxix
Howard E. Gendelman
Roger J. Bedimo
Linda Chang
Ian Paul Everall
Howard S. Fox
Harris A. Gelbard
Igor Grant
Scott L. Letendre
Stuart A. Lipton
Eliezer Masliah
Susan Swindells
Babafemi Taiwo
Section 1 HIV-1 Biology And Immunology
1.1 HIV-1 Biology
3(19)
Sergey Iordanskiy
Michael Bukrinsky
1.2 HIV-1 Immunology
22(14)
Sabita Roy
Krishnakumar Devadas
Subhash Dhawan
Shilpa Buch
1.3 Chemokines
36(14)
Richard J. Miller
1.4 Viral and Host Genetic Factors
50(21)
Jennifer A. McCombe
Shaona Acharjee
M. John Gill
Christopher Power
1.5 Genetic Susceptibilities for NeuroAIDS
71(22)
Srinivas Mummidi
Jason F. Okulicz
Edwina J. Wright
Weijing He
Sunil K. Ahuja
Section 2 Innate And Cellular Immunity And Neurogenesis
2.1 Mononuclear Phagocytes
93(16)
Kenneth C. Williams
William F. Hickey
Tricia H. Burdo
Caroline Soulas
2.2 Microglia
109(10)
Sunhee C. Lee
2.3 Astrocytes
119(12)
Etty N. Benveniste
Lisa N. Akhtar
Brandi J. Baker
2.4 Adaptive Immunity
131(15)
Jessica A. L. Hutter-Saunders
Larisa Y. Poluektova
Subhash Dhawan
Howard E. Gendelman
2.5 Vaccines
146(27)
Max V. Kuenstling
Eric J. Benner
R. Lee Mosley
2.6 Neurogenesis
173(16)
James B. Reinecke
Hui Peng
Yunlong Huang
Qiang Chen
Jialin C. Zheng
Section 3 Blood-Brain Barrier And HIV CNS Entry
3.1 Blood-Brain Barrier: Structure and Function
189(18)
William A. Banks
3.2 Endothelial Cell Biology and HIV-1 Infection
207(13)
Michal Toborek
Ibolya E. Andrds
Cetewayo S. Rashid
Yu Zhong
Shinsuke Nakagawa
3.3 Blood-Brain Barrier during Neuroinflammation
220(11)
Yuri Persidsky
Servio H. Ramirez
3.4 Mechanisms of Viral and Cell Entry into the Central Nervous System
231(15)
Eliseo A. Eugenin
Joan W. Berman
3.5 Monocyte-Macrophages and Viral Central Nervous System Entry
246(11)
Georgette D. Kanmogne
Section 4 Cellular and Viral Neurotoxicity and Abused Drugs
4.1 Mononuclear Phagocyte Inflammation and Neurotoxicity
257(18)
Andrea Martinez-Skinner
Ari S. Nowacek
Jo Ellyn McMillan
Howard E. Gendelman
4.2 Neurotoxicity of HIV-1 Proteins
275(14)
Manja Meggendorfer
Ina Rothenaigner
Bianca Tigges
Michelle Vincendeau
Ruth Brack-Werner
4.3 HIV-1 and Tat: Neuropathogenesis and Therapeutic Targets
289(16)
Wenxue Li
Guanhan Li
Joseph Steiner
Avindra Nath
4.4 HIV-1 gp120
305(13)
Shu-ichi Okamoto
Marcus Kaul
Ian Paul Everall
Eliezer Masliah
Stuart A. Lipton
4.5 HIV-1 and Cannabinoids
318(11)
Guy A. Cabral
Erinn S. Raborn
4.6 HIV-1 and Meth
329(9)
Howard S. Fox
4.7 HIV-1 and Opioids
338(16)
Toby K. Eisenstein
Jessica Breslow
Changcheng Song
Mathew J. Finley
William D. Cornwell
Sumedha Chugh
Joseph J. Meissler
Thomas J. Rogers
4.8 HIV-1 and Cocaine
354(11)
Shilpa Buch
Honghong Yao
Sabita Roy
Section 5 Animal Models
5.1 Simian Immunodeficiency Virus
365(12)
M. Christine Zink
Joseph L. Mankowski
David R. Graham
Lucio Gama
Janice E. Clements
5.2 Feline Immunodeficiency Virus
377(14)
Rick B. Meeker
5.3 Caprine Arthritis Encephalitis Virus and Visna
391(10)
Valgerdur Andresdottir
Sigurbjorg Torsteinsdottir
Gudmundur Georgsson
5.4 Transgenics
401(13)
Sulie L. Chang
Marley D. Kass
5.5 Murine Models for NeuroAIDS
414(17)
Larisa Y. Poluektova
5.6 Simian Immunodeficiency Virus and Opiates
431(7)
Shilpa Buch
Shannon Callen
Paul Cheney
Anil Kumar
5.7 SIV and FIV Models of Peripheral Neuropathy
438(8)
Victoria A. Laast
Gigi Ebenezer
Justin C. McArthur
Joseph L. Mankowski
5.8 Animal Models and Bioimaging
446(17)
Eva-Maria Ratai
Margaret R. Lentz
R. Gilberto Gonzalez
Section 6 Personal Perspectives In Living with HIV/AIDS
6.1 HIV and My Mental Health---A Personal Reflection
463(3)
Darren Kane
6.2 Fear and Loathing in HIV Mental Health Care
466(3)
Eric M. Glare
6.3 Memories
469(3)
James May
6.4 HIV Dementia: A Patient's Perspective. Living with the Suffering, the Diagnosis, and the Uncertainties
472(3)
Karen
6.5 My Virus Just Turned Twenty-One: A Woman's Perspective of the Long-term Psychological Impact of Living with HIV
475(6)
Susan Paxton
Section 7 Clinical and Pathologic Manifestations of Disease
7.1 Perspective on HIV CNS Infections
481(7)
Richard W. Price
7.2 HIV-Associated Neurocognitive Disorders
488(16)
Igor Grant
Ned Sacktor
7.3 The CNS in Acute and Early Infection
504(14)
Serena S. Spudich
7.4 HIV-1 Neuropathology
518(18)
Benjamin B. Gelman
David J. Moore
7.5 Peripheral Neuropathy
536(10)
Kathryn J. Elliott
Justin C. McArthur
David M. Simpson
7.6 Spinal Cord Disease
546(5)
Michael C. Previti
Christina M. Marra
7.7 Myopathy
551(16)
Jessica Robinson-Papp
Kenneth A. Fox
David M. Simpson
Susan Morgello
7.8 Aging
567(14)
Virawudh Soontornniyomkij
Cristian L. Achim
7.9 Addiction
581(20)
R. Douglas Bruce
Section 8 Pathogenesis of Comorbid Conditions
8.1 NeuroAIDS as an Inflammatory Disorder
601(18)
Denise R. Cook
Stephanie A. Cross
Samantha S. Soldan
Dennis L. Kolson
8.2 Neuronal Injury, White Matter Disease, and Neurotrophic Factors
619(14)
T. Dianne Langford
Ian Paul Everall
Eliezer Masliah
8.3 Pathobiology of HIV-related Neuropathies
633(10)
Nicholas W. S. Davies
Bruce J. Brew
8.4 CNS Comorbidities
643(18)
Georgette D. Kanmogne
David B. Clifford
8.5 Opportunistic Infections
661(60)
Joseph R. Berger
Bruce A. Cohen
8.6 Progressive Multifocal Leukoencephalopathy
721(8)
Maria G. Chiara
Eugene O. Major
8.7 Neoplasms
729(16)
Alexis Demopoulos
Lauren Abrey
8.8 Hepatitis C
745(7)
Li Ye
Wenzhe Ho
8.9 HIV and Psychiatric Comorbidities
752(11)
Timothy B. Nguyen
Ian Paul Everall
Section 9 Diagnostics and Biomarkers
9.1 Bioimaging
763(35)
Linda Chang
Ute Feger
Thomas M. Ernst
9.2 Magnetic Resonance Imaging
798(12)
Terry L. Jernigan
Sarah L. Archibald
Christine Fennema-Notestine
9.3 Psychological Evaluations
810(15)
Jordan Elizabeth Cattie
Steven Paul Woods
Igor Grant
9.4 Viral and Cellular Biomarkers during Antiretroviral Therapy
825(22)
Scott L. Letendre
Ronald J. Ellis
9.5 Viral Dynamics
847(9)
Davey M. Smith
Ronald J. Ellis
9.6 Viral Clades: Role in HIV Neuropathogenesis
856(5)
Wenxue Li
Avindra Nath
9.7 Proteomics and Biomarkers
861(14)
Gwenael Pottiez
Jayme Wiederin
Pawel Ciborowski
Section 10 Children and Adolescents
10.1 Clinical and Pathological Features of HIV-1 Encephalopathy in Children and Adolescents
875(32)
Mark Mintz
Leroy R. Sharer
Lucy A. Civitello
10.2 Infants, Children, and Adolescents: Nervous System Disease in the Era of Combination Antiretroviral Therapy
907(18)
Annelies Van Rie
Anna Dow
10.3 Psychosocial Aspects of Neurological Impairment in Children with AIDS
925(12)
Lori Wiener
Claude Mellins
10.4 Growing Up with HIV Disease
937(8)
Shirley F. Delair
Leslie K. Serchuck
Lynnae Schwartz
Section 11 Antiretroviral and Adjunctive Therapies
11.1 Current Concepts in the Treatment of HIV Infection with Focus on Brain Disease
945(17)
Susan Swindells
Uriel Sandkovsky
11.2 Pharmacology of Antiretroviral Therapies
962(16)
Scott L. Letendre
J. Allen McCutchan
Ronald J. Ellis
Brookie M. Best
Edmund V. Capparelli
11.3 Treatment of Opportunistic Infections Associated with Human Immunodeficiency Virus Infection
978(9)
David B. Clifford
11.4 Nanoformulated Medicines
987(12)
Upal Roy
Shantanu Balkundi
Jo Ellyn McMillan
Howard E. Gendelman
11.5 Antiretroviral Nanotherapies
999(6)
Madhavan P. N. Nair
Zainulabedin M. Saiyed
11.6 Adjunctive Medicines
1005(12)
Harris A. Gelbard
Stuart A. Lipton
Section 12 Psychiatry and Psychobiology
12.1 Psychiatric Disorders
1017(17)
J. Hampton Atkinson
Nichole A. Duarte
Glenn J. Treisman
12.2 Neurocognition in HIV and Substance Use Disorders
1034(11)
Andrew J. Levine
Raul Gonzalez
Eileen M. Martin
12.3 Psychobiology of Risk Behavior
1045(7)
David G. Ostrow
12.4 Everyday Impact of HIV-Associated Neurocognitive Disorders
1052(14)
Thomas D. Marcotte
J. Cobb Scott
Charles H. Hinkin
Robert K. Heaton
12.5 Facing Legal and Ethical Challenges in the Treatment of AIDS
1066(11)
Warren B. Treisman
Glenn J. Treisman
12.6 Neuropsychological Testing
1077(10)
Kevin R. Robertson
Kevin J. Liner
Michelle Ro
Robert K. Heaton
12.7 The Impact of HIV Subtype and Cultural and Sociodemographic Factors on HIV-1 Infection and Associated Neuropathogenesis in Africa
1087(12)
Adelina Holguin
Damien C. Tully
Charles Wood
Index 1099
Howard E. Gendelman, MD, Professor and Chair, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center Omaha, NE.

Igor Grant, MD, Distinguished Professor of Psychiatry, Director, HIV Neurobehavioral Research Program, University of California-San Diego, La Jolla, CA.

Ian Paul Everall, MD, PhD, Professor of Psychiatry and Head of Department, University of Melbourne, Victoria, Australia.

Howard S. Fox, MD, PhD, Professor, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE.



Harris A. Gelbard, MD, PhD, Director of The Center for Neural Development and Disease, Professor of Neurology, Pediatrics, Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY.

Stuart A. Lipton, MD, PhD, Professor and Scientific Director,



Sanford-Burnham Medical Research Institute; Adjunct Professor of Neurosciences, University of California-San Diego; Adjunct Professor, The Salk Institute for Biological Studies and The Scripps Research Institute, La Jolla, CA. Susan Swindells, MBBS, Professor of Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE.