General Description of Series
Since 1959, International Review of Neurobiology has been a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. This important serial is now being combined with Neuroscience Perspectives and Methods in Neurosciences. This combination results in a series that reaches a wider audience and publishes a greater number of thematic volumes.
General Description of Volume
Stroke is the third major cause of death in the western world, and recent data provide hope that treatments may soon be available. Written by world experts on the mechanisms involved in neurodegeneration, Neuroprotective Agents and Cerebral Ischaemia presents an up-to-date review of current research and developing therapies. This book is essential reading for all clinicians and researchers searching for neuroprotective drugs.
Key Features
* Describes the mechanisms involved in cell death and the biochemical changes occurring during an ischaemic episode
* Presents the different factors affecting the neurodegenerative process and how compounds acting on these systems may lead to novel neuroprotective agents
* Reviews in vitro and in vivo models of stroke and the activity of putative neuroprotective drugs
* Discusses the application of preclinical data to formulate approaches to a clinical problem
* Provides detailed reviews of both completed clinical trials and those currently underway
General Description of Series
Since 1959, International Review of Neurobiology has been a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. This important serial is now being combined with Neuroscience Perspectives and Methods in Neurosciences. This combination results in a series that reaches a wider audience and publishes a greater number of thematic volumes.
General Description of Volume
Stroke is the third major cause of death in the western world, and recent data provide hope that treatments may soon be available. Written by world experts on the mechanisms involved in neurodegeneration, Neuroprotective Agents and Cerebral Ischaemia presents an up-to-date review of current research and developing therapies. This book is essential reading for all clinicians and researchers searching for neuroprotective drugs.
Key Features
* Describes the mechanisms involved in cell death and the biochemical changes occurring during an ischaemic episode
* Presents the different factors affecting the neurodegenerative process and how compounds acting on these systems may lead to novel neuroprotective agents
* Reviews in vitro and in vivo models of stroke and the activity of putative neuroprotective drugs
* Discusses the application of preclinical data to formulate approaches to a clinical problem
* Provides detailed reviews of both completed clinical trials and those currently underway
Recenzijas
"In balance, I recommend this book as a superior volume, whose high 'power-to-weight ratio,' readability, and availability in paperback make it attractive for personal use." --TRENDS IN NEUROSCIENCES
Papildus informācija
Key Features * Describes the mechanisms involved in cell death and the biochemical changes occurring during an ischaemic episode * Presents the different factors affecting the neurodegenerative process and how compounds acting on these systems may lead to novel neuroprotective agents * Reviews in vitro and in vivo models of stroke and the activity of putative neuroprotective drugs * Discusses the application of preclinical data to formulate approaches to a clinical problem * Provides detailed reviews of both completed clinical trials and those currently underway
Mechanisms of Nerve Cell Death: Apoptosis or Necrosis after Cerebral
Ischaemia, R.M.E. Chalmers-Redman, A.D. Fraser, W.Y.H. Ju, J. Wadia, N.A.
Tatton, and W.G. Tatton.
Changes in Ionic Fluxes during Cerebral Ischaemia, T. Kristiįn and B.K.
Siesjö.
Techniques for Examining Neuroprotective Drugs in Vivo, A.R. Green and A.J.
Cross.
Techniques for Assessing Neuroprotective Drugs in Vitro, M. P. Goldberg, U.
Strasser and L.L. Dugan.
Calcium Antagonists: Their Role in Neuroprotection, A.J. Hunter.
Sodium and Potassium Channel Modulators: Their Role in Neuroprotection, T.P.
Obrenovich.
NMDA Antagonists: Their Role in Neuroprotection, D.L. Small and A.M. Buchan.
Development of the NMDA Ion-Channel Blocker Aptiganel Hydrochloride as a
Neuroprotective Agent for Acute CNS Injury, R.N. McBurney.
Pharmacology of AMPA Antagonists and their Role in Neuroprotection, R. Gill
and D. Lodge.
GABA and Neuroprotection, P.D. Lyden.
Adenosine and Neuroprotection, B.B. Fredholm.
Interleukins and Cerebral Ischaemia, N.J. Rothwell, S.A. Loddick, and P.
Stroemer.
Nitrone-Based Free Radical Traps as Neuroprotective Agents in Cerebral
Ischaemia and other Pathologies, K.Hensley, J.M. Carney, C.A. Stewart, T.
Tabatabaie, Q. Pye, and R.A. Floyd.
Neurotoxic and Neuroprotective Roles of Nitric Oxide in Cerebral Ischaemia,
T. Dalkara and M.A. Moskowitz.
A Review of Earlier Clinical Studies on Neuroprotective Agents and Current
Approaches, N.G. Wahlgren.
Index.
Contents of Recent Volumes.
Professor Peter Jenner is a specialist in preclinical aspects of neurodegenerative diseases, notably Parkinsons disease. He has spent the major part of his career at Kings College London where he was Head of Pharmacology for 14 years before returning to his research roots and subsequently becoming Emeritus Professor of Pharmacology. Peter has expertise in drug metabolism and pharmacokinetics but neuropharmacology based on functional models of neurodegenerative diseases has formed the major focus of his work. Peter holds a BPharm, PhD and DSc degree from the University of London. He has published well over 1000 articles with more than 700 peer reviewed papers. He is a Fellow of the Royal Pharmaceutical Society, the British Pharmacological Society, the Royal Society of Medicine and of Kings College London. Peter was recently honoured with a Doctor Honoris Causa degree from Carol Davila University of Medicine and Pharmacy, Bucharest and made an Honorary Fellow of The British Pharmacological Society for his contribution to research in to movement disorders.
Peter has worked closely with the pharmaceutical industry for many years and acts as an adviser and consultant to both major pharma and biotech companies. He has a wide knowledge of the drug discovery and drug development process and has been involved from molecule synthesis through to drug registration for use in man. Peter was the Founder, Director and Chief Scientific Officer of Proximagen, a biotech focussed on the treatment and cure of neurodegenerative diseases that was listed on AIMs and subsequently purchased by a US based healthcare company. He is a regular speaker at international meetings and also takes time to speak at Parkinsons disease patient-carer groups across the UK. Alan Cross was at the MRC Clinical Research Centre, London, followed by two years as a lecturer in the Department of Physiology, University of Manchester. In 1980 he became Head of Pharmacology at the Aston Neuroscience Research Unit.
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