This book discusses the mechanism and therapeutic strategies of phytochemicals against brain ageing. It discusses the underlying anti-oxidative and anti-inflammatory mechanisms of the phytochemicals and the implications of these compounds in the prevention and treatment of geriatric diseases. It discusses the potential role of the highly complex interactive network between the gut and the brain in neurodegenerative diseases such as Parkinsons disease (PD), and Alzheimers disease. The chapters provide insight into the mechanisms involved in brain ageing and the mechanism of actions of the phytochemicals that might be crucial in developing effective new therapies against brain ageing. The chapter also presents the mechanisms of action of phytoconstituents, bioavailabilities, and their effects on neuroinflammation. The chapters also examine the phytochemicals protection of neurons via targeting oxidative stress, mitochondrial dysfunction, neurotrophic factor deficit, apoptosis, and abnormal protein accumulation. This book aims to provide comprehensive and cutting-edge information on the potential neuroprotective role of phytochemicals on the brain and neurological disorders to researchers, neuroscientists, clinical nutritionists, and physicians.
Chapter-1 Phytochemicals as potential protective agents for brain
aging.
Chapter-2 Molecular mechanism of brain aging: Protective effects of
phytochemicals.
Chapter-3 Response of cellular stress towards the hormetic
phytochemicals in brain aging.
Chapter-4 Synergistic effects of
multifunctional phytochemicals modulating the cellular signal pathways- as
neuroprotective therapeutic approach for neurodegenerative disorders.-
Chapter-5 Impact of aging, lifestyle, and phytochemicals on the commencement
of neurological diseases.
Chapter-6 Recent Advancement in medicinal
chemistry in formulations of phytochemicals against brain aging.
Chapter-7
Repurposing of Drugs in brain Aging.
Chapter-8 Ethanopharmacology: A boon
for aging brain.
Chapter-9 Natural extracts and phytochemicals: Secondary
metabolites of plants and the improvement of brain function.
Chapter-10
Flavonoids: A promosing Neuroprotectants and its Salutary Effects on
age-related neurodegenerative disorders.
Chapter-11 Bioactive compounds of
algae: Potential neuroprotective agents in neurodegenerative disorders.-
Chapter-12 Phytochemical supplementation modulates cell survival signaling
and regulates immune function through sympathetic innervation in ageing.-
Chapter-13 POTENTIAL EFFECTS OF HUMAN ANTI-AGING COMPOUNDS: IMPLICATIONS ON
BRAIN AGING.
Chapter-14 Advantages and disadvantages of current therapeutics
and phytochemicals in age-related brain disorders.
Chapter-14 Advantages and
disadvantages of current therapeutics and phytochemicals in age-related brain
disorders.
Chapter-16 The controversy surrounding drugs against
Neurodegeneration: Benefit or Harm?.
Prof. Surajit Pathak, PhD, is currently working as a professor at Chettinad Academy of Research and Education, Kelambakkam, Chennai (From 2015till date). He worked as a principal research scientist in Linkoping University, Linkoping, Sweden (2022 JuneDec 2022). He has received his PhD degree from India in 2007 and completed his post-doctoral training (20072015) at the University of Alabama, USA, University of Padova, Italy, and University of Linkoping, Sweden.
His current research focuses on role of intra and extracellular microRNAs for early detection of colorectal cancer. He has published more than 125 research and review articles in peer-reviewed international journals of repute with 2800 citations and 30 h-index.
He is the editorial board member of various renowned journals. Prof. Pathak has edited several books of Springer Nature Cancer Stem Cells: New Horizons in Cancer Therapies, MRW book Handbook of Animal Models and its Uses in Cancer Research and Evidence-Based Functional Foods for Prevention of Age-related Diseases. He is the member of various professional research bodies of India including Indian Association of Cancer Research, Indian Science Congress and Aesthetic Multispecialty Society, Europe (AMS).
Dr. Antara Banerjee is presently working as an associate professor at Chettinad Academy of Research and Education, Chennai, from 2016 till date. She completed her PhD in 2008 and pursued her post-doctoral research at the University of Padova, Italy (20092012), and later she joined as a senior research associate in the University of Linkoping, Sweden (20132015).
She has published over 105 research and review articles in peer-reviewed international and national journals with citation index-1900 and h-index-23. She is serving as an editorial board member and reviewer in several international and national journals. She is the editor of books with Springer Publishers namely Cancer Stem Cells: New Horizons in Cancer Therapies, Handbook of Animal Models and Its Uses in Cancer Research and Evidence-Based Functional Foods for Prevention of Age-related Diseases. She is the lifetime member of Indian Association of Cancer Research, Indian Science Congress.
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