International Review of Neurobiology, Volume 46 presents in-depth reviews on such ground-breaking topics as assembly and intracellular trafficking of GABA A receptors, D-1 dopamine receptors, and Alzheimer's disease. This series offers the most comprehensive and up-to-date information available and is a must for anyone in the field.
Includes a historical overview of neurosteroid research
Contains a chapter on neurosteroid biosynthesis and regulation
Presents current methods of neurosteroid measurement and analysis
Discusses neurosteroid function in both the normal and the pathological brain
Chapters address the function of neurosteroid in:
Stress
Receptor plasticity and function
Learning and Memory
Alcohol use
Depression
Papildus informācija
Includes a historical overview of neurosteroid research Contains a chapter on neurosteroid biosynthesis and regulation Presents current methods of neurosteroid measurement and analysis Discusses neurosteroid function in both the normal and the pathological brain Chapters address the function of neurosteroid in: Stress Receptor plasticity and function Learning and Memory Alcohol use Depression
Contributors xiii Preface xvii Neurosteroids: Beginning of the Story Etienne E. Baulieu P. Robel M. Schumacher Introduction 2(5) Biosynthesis and Metabolism of Neurosteroids: Related Behavioral Effects 7(6) Receptors and Related Activities of Neurosteroids 13(12) Conclusions 25(9) References 26(8) Biosynthesis of Neurosteroids and Regulation of Their Synthesis Synthia H. Mellon Hubert Vaudry What Is a Neurosteroid? 34(1) Enzymes Involved in Neurosteroidogenesis: Biochemistry and Molecular Biology 35(14) Enzymes Involved in Neurosteroidogenesis: Distribution in the Brain and Developmental Regulation 49(12) Regulation of Neurosteroidogenic Enzymes 61(4) Conclusions 65(14) References 66(13) Neurosteroid 7-Hydroxylation Products in the Brain Robert Morfin Luboslav Starka Neurosteroid Metabolism in the Brain 79(2) 7α-Hydroxylation Studies in the Brain 81(2) 7β-Hydroxylation Studies in the Brain 83(1) 7α-Hydroxy-DHEA and 7β-Hydroxy-DHEA as Native Anti-glucocorticoids 84(4) The Brain and Other Organs 88(2) Sex Steroid Metabolism in the Brain 90(2) Conclusions 92(6) References 92(6) Neurosteroid Analysis Ahmed A. Alomary Robert L. Fitzgerald Robert H. Purdy Introduction 98(1) Analysis of Neurosteroids by Radiommunoassay 99(1) Analysis of Neurosteroids by High-Performance Liquid Chromatography Coupled with Gas Chromatography-Mass Spectrometry 99(1) Analysis of Unconjugated Neurosteroids by Gas Chromatography-Mass Spectrometry 100(3) Derivatization of Neurosteroids 103(3) Gas Chromatography Columns for Separation of Neurosteroid Derivatives 106(1) Isotopic Dilution for Quantitative Gas Chromatography-Mass Spectrometry 107(1) Data Acquisition Modes in Mass Spectrometry 107(1) Mass Spectrometry/Mass Spectrometry 108(1) Analysis of Neurosteroid Sulfates by Mass Spectrometry 108(1) Analysis of Sulfated Steroids by Soft Ionization Mass Spectrometry 109(2) Analysis of Steroid Sulfates by Atmospheric Pressure Chemical Ionization/Mass Spectrometry 111(1) Thermospray Liquid Chromatography/Mass Spectrometry 111(1) Future Analysis of Neurosteroid Sulfates 111(1) Conclusions 112(6) References 112(6) Role of the Peripheral-Type Benzodiazepine Receptor in Adrenal and Brain Steroidogenesis Rachel. C. Brown Vassilios Papadopoulos Introduction 118(1) Peripheral-Type Benzodiazepine Receptor 119(1) Structure of the PBR Complex 120(4) Role of the PBR in Steroidogenesis 124(4) The PBR in Adrenal Steroid Biosynthesis 128(3) Role of the PBR in Brain Neurosteroid Biosynthesis 131(3) Role of the PBR in Pathology 134(1) Other Proteins Involved in the Acute Regulation of Steroidogenesis 135(2) Conclusions 137(9) References 137(9) Formation and Effects of Neuroactive Steroids in the Central and Peripheral Nervous System Roberto Cosimo Melcangi Valerio Magnaghi Mariarita Galbiati Luciano Martini Introduction 146(1) 5α-Reductase and 3α-Hydroxysteroid Dehydrogenase System 146(7) Effect of Glial-Neuronal Interactions on the Formation of Neuroactive Steroids 153(2) Effects of Neuroactive Steroids on Glial Cells of the Central Nervous System 155(6) Formation of Neuroactive Steroids in the Peripheral Nervous System 161(1) Effects of Neuroactive Steroids on the Peripheral Nervous System 162(8) Conclusions 170(8) References 170(8) Neurosteroid Modulation of Recombinant and Synaptic GABAA Receptors Jeremy J. Lambert Sarah C. Harney Delia Belelli John A. Peters Introduction 178(2) Transmitter-Gated Ion Channels and Neurosteroid Selectivity 180(5) Influence of GABAA-Receptor Subunit Composition on Neurosteroid Action 185(3) Mechanism of Neurosteroid Modulation of GABAA Receptors 188(2) Neurosteroid Modulation of Inhibitory Synaptic Transmission 190(4) Structure--Activity Relationships for Steroids at the GABAA Receptor 194(2) Multiple Steroid Binding Sites on the GABAA Receptor 196(1) Conclusions 197(11) References 199(9) GABAA-Receptor Plasticity during Long-Term Exposure to and Withdrawal from Progesterone Giovanni Biggio Paolo Follesa Enrico Sanna Robert H. Purdy Alessandra Concas Introduction 208(1) Effects of Long-Term Exposure to PROG and GABAA-Receptor Gene Expression and Function in Vitro 209(7) Effects of PROG Withdrawal on GABAA-Receptor Gene Expression and Function in Vitro 216(2) Effects of Long-Term Exposure to and Subsequent Withdrawal of PROG in Pseudo-pregnancy 218(2) Effects of Long-Term Exposure to and subsequent Withdrawal of PROG in Pregnancy 220(11) Oral Contraceptives and GABAA-Receptor Plasticity 231(3) Mechanism of the Effect of Long-Term PROG Exposure on GABAA-Receptor Plasticity 234(1) Conclusions 235(9) References 235(9) Stress and Neuroactive Steroids Maria Luisa Barbaccia Mariangela Serra Robert H. Purdy Giovanni Biggio Stress and GABAA Receptors 244(2) Effect of Stress on Brain Concentrations of Neuroactive Steroids 246(15) Possible Mechanisms Underlying the Stress-Induced Changes in Brain Neurosteroid Concentrations 261(2) Conclusions 263(11) References 264(10) Neurosteroids in Learning and Memory Processes Monique Vallee Willy Mayo George F. Koob Michel, Le Moal Introduction 274(1) Learning and Memory Processes and Animal Models 275(5) Pharmacological Effects of Neurosteroids 280(12) Mechanisms of Action 292(9) Physiological Significance 301(8) Conclusions and Future Perspectives 309(12) References 312(9) Neurosteroids and Behavior Sharon R. Engel Kathleen A. Grant Introduction 321(1) Anxiety and Stress 322(6) Cognition 328(5) Aggression 333(2) Sleep, Feeding, and Reinforcement 335(2) Discriminative Stimulus Effects 337(12) References 342(7) Ethanol and Neurosteroid Interactions in the Brain A. Leslie Morrow Margaret J. Vandoren Rebekah Fleming Shannon Penland Introduction 349(2) Role of 3α,5α-TH PROG in Ethanol Action 351(8) Role of Neurosteroids in Alcohol Reinforcement 359(2) Role of Neurosteroids in Ethanol Tolerance 361(3) Role of Neurosteroids in Ethanol Dependence 364(5) Conclusions and Future Directions 369(11) References 369(11) Preclinical Development of Neurosteroids as Neuroprotective Agents for the Treatment of Neurodegenerative Diseases Paul A. Lapchak Dalia M. Araujo Neurosteroids and the Brain 380(1) Synthesis of Central Nervous System Neurosteroids 380(1) Receptor Signaling Pathways 381(3) Neurosteroids and Central Nervous System Plasticity 384(1) Neurosteroids and Neuroprotection 384(7) Conclusions 391(8) References 391(8) Clinical Implications of Circulating Neurosteroids Andrea R. Genazzani Patrizia Monteleone Massimo Stomati Francesca Bernardi Luigi Cobellis Elena Casarosa Michele Luisi Stefano Luisi Felice Petraglia Introduction 399(3) Changes and Possible Role of Neurosteroids in Humans 402(20) References 414(8) Neuroactive Steroids and Central Nervous System Disorders Mingde Wang Torbjorn Backstrom Inger Sundstrom Goran Wahlstrom Tommy Olsson Di Zhu Inga-Maj Johansson Inger Bjorn Marie Bixo Neuroactive Steroids and the Central Nervous System 422(3) Concentrations of Neuroactive Steroids in the Brain 425(3) Sensory-Motor and Cognitive Function 428(1) Estrogen and Alzheimers Disease 429(1) Neuroactive Steroids and Menstrual-Cycle-Linked Mood Changes 430(5) Side Effects of Oral Contraceptives 435(1) Neuroactive Steroids and Menopause 436(3) Side Effects of Hormone Replacement Therapy 439(2) Neuroactive Steroids and Epilepsy 441(21) References 448(14) Neuroactive Steroids in Neuropsychopharmacology Rainer Rupprecht Florian Holsboer Introduction 462(1) Sources and Biosynthesis of Neuroactive Steroids 463(2) Steroid Modulation of GABAA Receptors 465(1) Steroid Modulation of Other Neurotransmitter Receptors 466(2) A Putative Specific Steroid-Binding Site on Ligand-Gated Ion Channels 468(1) Genomic Effects of Neuroactive Steroids 469(1) Neuropsychopharmacological Properties of Neuroactive Steroids 470(1) Modulation of Endogenous Neuroactive Steroids as a Pharmacological Principle 471(1) Outlook 472(7) References 474(5) Current Perspectives on the Role of Neurosteroids in PMS and Depression Lisa D. Griffin Susan C. Conrad Synthia H. Mellon Introduction 479(1) Premenstrual Syndrome or Premenstrual (Late Luteal) Dysphoric Disorder 480(1) Allopregnanolone and Premenstrual Dysphoric Disorder 481(2) Biosynthesis of Allopregnanolone 483(2) SSRIs in the Treatment of Premenstrual Dysphoric Disorder: Modulation of Neurosteroid Levels 485(2) SSRIs, Neurosteroids, and Depression 487(2) Conclusions 489(4) References 489(4) Index 493(14) Contents of Recent Volumes 507
Professor Peter Jenner is a specialist in preclinical aspects of neurodegenerative diseases, notably Parkinsons disease. He has spent the major part of his career at Kings College London where he was Head of Pharmacology for 14 years before returning to his research roots and subsequently becoming Emeritus Professor of Pharmacology. Peter has expertise in drug metabolism and pharmacokinetics but neuropharmacology based on functional models of neurodegenerative diseases has formed the major focus of his work. Peter holds a BPharm, PhD and DSc degree from the University of London. He has published well over 1000 articles with more than 700 peer reviewed papers. He is a Fellow of the Royal Pharmaceutical Society, the British Pharmacological Society, the Royal Society of Medicine and of Kings College London. Peter was recently honoured with a Doctor Honoris Causa degree from Carol Davila University of Medicine and Pharmacy, Bucharest and made an Honorary Fellow of The British Pharmacological Society for his contribution to research in to movement disorders.
Peter has worked closely with the pharmaceutical industry for many years and acts as an adviser and consultant to both major pharma and biotech companies. He has a wide knowledge of the drug discovery and drug development process and has been involved from molecule synthesis through to drug registration for use in man. Peter was the Founder, Director and Chief Scientific Officer of Proximagen, a biotech focussed on the treatment and cure of neurodegenerative diseases that was listed on AIMs and subsequently purchased by a US based healthcare company. He is a regular speaker at international meetings and also takes time to speak at Parkinsons disease patient-carer groups across the UK.
