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E-grāmata: New Antibody Formats

Volume editor (CIMA Universidad de Navarra, Program of Immunology and Immunotherapy, Spain), Volume editor (Assistant Professor of Cell Biology in Radiation Oncolo), Volume editor (Fernando Aranda Vega, CIMA Universidad de Navarra, Program of Immunology and Immunotherapy, Spain)
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New Antibody Formats, Volume 369 in the International Review of Cell and Molecular Biology serial, highlights new advances in the field with this new volume presenting interesting chapters on a variety of important topics, including Current innovative engineered antibodies, Advances in bispecific antibodies, Applications of trimerbodies for cancer immunotherapy, Multispecific mAb-Anticalin formats, New antibody formats to treat Lung Cancer, Immunocytokines: from bench to bedside, and Single domain antibodies in cancer.
  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the International Review of Cell and Molecular Biology serials
  • Updated release includes the latest information on New Antibody Formats
Contributors ix
1 Current innovative engineered antibodies
1(44)
Jose Yelamos
1 Introduction
2(1)
2 Historical overview of antibody engineering
3(20)
3 Bispecific antibodies
23(1)
4 Nanobodies
24(1)
5 Intrabodies
24(1)
6 Fine-tuning Fc-dependent effector functions
25(6)
7 Antibody-drug conjugates
31(4)
8 Engineered antibody fusion proteins
35(1)
9 CAR-T and CAR-NK cells
36(2)
10 Conclusions
38(7)
Acknowledgments
38(1)
References
38(7)
2 Opportunities and challenges of bi-specific antibodies
45(26)
Aina Segues
Shuyu Huang
Alice Sijts
Pedro Berraondo
Dietmar M. Zaiss
1 Introduction
46(1)
2 Cis-versus trans-targeting bispecific antibodies
47(1)
3 Technical challenges in the design and production of bispecific antibodies
48(7)
4 Examples of BsAbs approved for clinical application
55(3)
5 Further opportunities for bispecific antibodies on the example of regulatory T-cells
58(4)
6 Current bi-specific antibodies targeting regulatory T-cells
62(1)
7 Concluding remarks
63(8)
Funding
64(1)
Disclosure statement
64(1)
References
64(7)
3 Applications of trimerbodies in cancer immunotherapy
71(18)
Marta Compte
Laura Sanz
Luis Alvarez-Vallina
1 Introduction
72(1)
2 Next-generation antibodies
72(1)
3 The trimerbody concept and evolution
73(3)
4 Trimerbodies in cancer immunotherapy
76(5)
5 Trimerbodies in cancer diagnosis
81(1)
6 Conclusions and future prospects
82(7)
Acknowledgments
83(1)
Competing interests
83(1)
References
83(6)
4 Anticalin®-based therapeutics: Expanding new frontiers in drug development
89(18)
Aizea Morales-Kastresana
Martin Siegemund
Stefan Haak
Janet Peper-Gabriel
Vanessa Neiens
Christine Rothe
1 Introduction
90(1)
2 Anticalin protein technology
91(2)
3 Format opportunities for Anticalin proteins
93(2)
4 Plasma half-life engineering of Anticalin proteins
95(1)
5 Anticalin protein based multispecifics for potential treatment of infectious diseases
96(1)
6 Antibody-Anticalin fusion formats for cancer immunotherapy
97(2)
7 Armoring cancer immunotherapies with Anticalin protein-based payloads
99(2)
8 Inhalable Anticalin proteins for local lung delivery
101(1)
9 Concluding remarks
102(5)
References
102(5)
5 Overcoming the limitations of cytokines to improve cancer therapy
107(36)
Claudia Augusta Di Trani
Assunta Cirella
Leire Arrizabalaga
Myriam Fernandez-Sendin
Angela Bella
Fernando Aranda
Ignacio Melero
Pedro Berraondo
1 Introduction
108(2)
2 Strategies to modulate the activity
110(3)
3 Strategies to increase the half-life
113(4)
4 Strategies to target the tumor microenvironment
117(6)
5 In vivo production of cytokines
123(6)
6 Conclusions
129(14)
Acknowledgments
132(1)
References
132(11)
6 Emerging applications of nanobodies in cancer therapy
143
Robin Maximilian Awad
Fien Meeus
Hannelore Ceuppens
Thomas Ertveldt
Heleen Hanssens
Quentin Lecocq
Lukasz Mateusiak
Katty Zeven
Hana Valenta
Timo W.M. De Groof
Yannick De Vlaeminck
Ahmet Krasniqi
Kim De Veirman
Cleo Goyvaerts
Matthias D'Huyvetter
Sophie Hernot
Nick Devoogdt
Karine Breckpot
1 Introduction
144(3)
2 Nanobodies: Small antigen-binding proteins with a big impact on conventional cancer therapies
147(12)
3 Nanobodies: Emerging applications in cancer immunotherapy
159(23)
4 Conclusion
182
References
182
Fernando Aranda holds a BSc in Biology (2006) and Biochemistry (2007) from the University of Navarra. Then, he specialized in different strategies of Cancer Immunotherapy with a MSc in Biomedical Research (2008), and a PhD Degree (2012) from the University of Navarra (Pamplona) Cima University of Navarra. More than 12 years in translational research focus on antitumor immune responses and Cancer Immunotherapy. Author of 64 publications indexed in PubMed in prestigious international journals, with h-index 30 and 4,296 cites (October 2022). He completed the Program of Sara Borrell (ISCIII) -competitive Postdoctoral contract- in the Group of Immune Receptors of the Innate and Adaptive System (IDIBAPS), Barcelona (2016-2018). Co-author of 1 invention patent: Composition based on the fibronectin domain A for the treatment of melanoma - WO/2011/101332. In 2012, Fernando Aranda obtained a Scientific Award, "Profesor Durantez" II Edición, for the best scientific article in Tumor Immunology by Fundación LAIR. Recently, Fernando Aranda awarded a competitive Research Fellow contract Miguel Servet tipo I” by Instituto de Salud Carlos III, to continue his independent researcher career (IP) in cancer immunotherapy issues. Specifically, he is involved in Translational Immunotherapy of Peritoneal Carcinomatosis. Currently, Fernando Aranda leads a research group in cooperation with Dr. Pedro Berraondo. Pedro Berraondo graduated in Pharmacy at the University of Navarra in 1999. In 2004 he obtained the Ph.D. at the same university. Next, he worked at the Pasteur Institute in Paris (France) under the supervision of Dr. Claude Leclerc, where he developed novel strategies in tumor immunotherapy within the European THERAVAC project. In February 2007, he joined the Immunology and Immunotherapy Program at the Cima Universidad de Navarra, where he leads the Cytokine-based Immunotherapy laboratory. He is co-inventor of ten patents and he is co-author of more than 140 publications, including publications in Nature, Nature Medicine, Nature Reviews Drug Discovery, Immunity, Cancer Discovery, and Cancer Cell. He was certified as a full professor in 2021 by AQU. He is co-director of the degree of expert in immunooncology at the Faculty of Medicine of the University of Navarra, and is in charge of the undergraduate course of macromolecular structure at the Faculty of Sciences of the University of Navarra. He is also the coordinator of the immuno-oncology work module at CIBERONC. Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.

Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.