| I The International Solvay Institutes |
|
xi | |
| II Solvay Scientific Committee for Chemistry |
|
xiii | |
| III Acknowledgements |
|
xv | |
| IV Participants |
|
xvi | |
| V Auditors |
|
xviii | |
| VI Opening Address |
|
xix | |
|
|
| VII Preface |
|
xxi | |
|
|
|
Session 1 New Chemistry in the Expanding Protein Universe |
|
|
1 | (56) |
|
1.1 Novel Chemistry Still to be Found in Nature |
|
|
3 | (3) |
|
|
|
1.2 Natural Product Biosynthesis in the Genomic Age |
|
|
6 | (5) |
|
|
|
1.3 Peptide Dendrimers and Polycyclic Peptides |
|
|
11 | (5) |
|
|
|
1.4 What can Comparative Genomics Reveal about the Mechanisms of Protein Function Evolution? |
|
|
16 | (4) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1.5 Exploring Chromatin Biology Using Protein Chemistry |
|
|
20 | (3) |
|
|
|
1.6 Our Expanding Protein Universe |
|
|
23 | (5) |
|
|
|
1.7 The Scientific Impact of Freely Available Chemical Probes |
|
|
28 | (3) |
|
|
|
1.8 Discussions of Session 1 |
|
|
31 | (26) |
|
Session 2 Exploring Enzyme Families and Enzyme Catalysis |
|
|
57 | (60) |
|
2.1 Mechanistic Enzymology and Catalyst Design |
|
|
59 | (5) |
|
|
|
2.2 Looking in New Directions for the Origins of Enzymatic Rate Accelerations |
|
|
64 | (6) |
|
|
|
2.3 Computational Enzyme Design and Methods to Predict the Role of Remote Mutations |
|
|
70 | (5) |
|
|
|
2.4 Discovering Novel Enzymes, Metabolites and Pathways |
|
|
75 | (4) |
|
|
|
2.5 Programming New Chemistry into the Genetic Code of Cells and Animals |
|
|
79 | (5) |
|
|
|
2.6 Expanding the Enzyme Universe through a Marriage of Chemistry and Evolution |
|
|
84 | (6) |
|
|
|
2.7 Controlled Radical Reactions in Biology and the Importance of Metallo-Cofactor Biosynthesis |
|
|
90 | (4) |
|
|
|
2.8 Discussions of Session 2 |
|
|
94 | (23) |
|
Session 3 Microbiomes and Carbohydrate Chemistry |
|
|
117 | (60) |
|
3.1 Structural Basis for Host/Commensal-Microbe Interactions in the Human Distal Gut Microbiome |
|
|
119 | (6) |
|
|
|
3.2 Carbohydrate Chemistry and Biology |
|
|
125 | (5) |
|
|
|
3.3 Chemical Biological Proteomics of Bacterial Protein Functionalities in the Human Distal Gut Microbiome |
|
|
130 | (6) |
|
|
|
3.4 Automated Oligosaccharide Synthesis: From Insights into Fundamental Glycobiology to Vaccines and Diagnostics |
|
|
136 | (5) |
|
|
|
3.5 Carbohydrate-Active Enzymes in Microbiomes |
|
|
141 | (5) |
|
|
|
3.6 The Microbiome(s): Microbiota, Families, Functions |
|
|
146 | (4) |
|
|
|
3.7 N-Linked Protein Glycosylation |
|
|
150 | (4) |
|
|
|
3.8 Discussions of Session 3 |
|
|
154 | (23) |
|
Session 4 GPCRs and Transporters: Ligands, Cofactors, Drug Development |
|
|
177 | (52) |
|
4.1 GPCRs and Transporters: Ligands, Cofactors, Drug Development |
|
|
179 | (3) |
|
|
|
4.2 Studies of GPCR Conformations in Non-Crystalline Milieus |
|
|
182 | (4) |
|
|
|
4.3 The Seven Transmembrane Superfamily |
|
|
186 | (6) |
|
|
|
4.4 Nanobodies for the Structural and Functional Investigation of GPCR Transmembrane Signaling |
|
|
192 | (3) |
|
|
|
|
|
4.5 The Hidden Pharmacology of the Human GPCR-ome |
|
|
195 | (4) |
|
|
|
4.6 Structures and Reaction Mechanisms of ABC Transporters |
|
|
199 | (4) |
|
|
|
4.7 Discussions of Session 4 |
|
|
203 | (26) |
|
Session 5 Biologicals and Biosimilars |
|
|
229 | (56) |
|
5.1 Biologicals and Biosimilars |
|
|
231 | (6) |
|
|
|
|
|
5.2 Platform Technologies for the Artificial Pseudo-Natural Product Discovery |
|
|
237 | (6) |
|
|
|
5.3 Anticalins® & Pasylation®: New Concepts for Biopharmaceutical Drug Development from Protein Design |
|
|
243 | (6) |
|
|
|
5.4 From Natural Antibodies to Synthetic Proteins |
|
|
249 | (5) |
|
|
|
5.5 From Intact Antibodies to Armed Antibodies |
|
|
254 | (3) |
|
|
|
5.6 Regulating Cellular Life Death and Development Using Intracellular Combinatorial Antibody Libraries |
|
|
257 | (3) |
|
|
|
|
|
|
|
|
|
|
|
|
|
5.7 Nanobodies: A Universe of Variable Domains and a Toolbox for Many Trades |
|
|
260 | (6) |
|
|
|
5.8 Discussions of Session 5 |
|
|
266 | (19) |
|
Session 6 Proteins in Supramolecular Machines |
|
|
285 | (60) |
|
6.1 Assembly of Filamentous Type 1 Pili from Uropathogenic Escherichia Coli Strains |
|
|
287 | (6) |
|
|
|
6.2 HIV Envelope and Influenza Hemagglutinin Fusion Glycoproteins and the Quest for a Universal Vaccine |
|
|
293 | (6) |
|
|
|
6.3 Deconstruction of Iterative Polyketide Synthases |
|
|
299 | (6) |
|
|
|
6.4 Regulating Ribosome Pausing During Translation |
|
|
305 | (3) |
|
|
|
6.5 The Molecular Mechanics of the Ribosome |
|
|
308 | (5) |
|
|
|
|
|
|
|
|
|
|
|
6.6 Exploring the Dynamics of Supramolecular Machines with Cryo-Electron Microscopy |
|
|
313 | (5) |
|
|
|
6.7 Crystallographic Studies of Eukaryotic Ribosomes and Functional Insights |
|
|
318 | (5) |
|
|
|
6.8 Discussions of Session 6 |
|
|
323 | (22) |
| Index |
|
345 | |
Biežāk uzdotie jautājumi par e-grāmatām