New-Delhi metallo--lactamase (NDM) is a chimeric enzyme containing among the most worrying bacterial resistance markers. This book reviews knowledge from all concerned areas, and links the knowledge to display a full picture of NDM.Chemists, physicians, why biologists, will discover why particular genetic features caused the anchoring of NDM to the outer membrane, and endow it with the capacities to overcome scarce zinc conditions, more stability, and fast transfer. Starting from its discovery in India, tracking it throughout the world, this book will describe its mechanism, and highlight the assets brought by each mutation.This review aims to gather all information about NDM from any research field, and to explain causes and consequences in a language understandable for all scientists.
Katharina Fromm is Full Professor at the University of Fribourg, Switzerland. After her studies of Chemistry at the University of Karlsruhe in Germany, and a stay at Ecole des Hautes Etudes des Industries Chimiques de Strasbourg (now ECPM) in Strasbourg, France, she did her PhD at the University of Karlsruhe, Germany, with Prof. Evamarie Hey-Hawkins (now University of Leipzig) on organometallic compounds with metal-phosphor double bonds. After postdocs with Prof. J. Strähle, Prof. J.M. Lehn, and Profs. D. Fenske and R. Ahlrichs, she got her habilitation with Prof. A. F. Williams at the University of Geneva, Switzerland. Katharina then got a research professorship position with the SNF (Swiss National Science Foundation) at the University of Basel, Switzerland, before joining the University of Fribourg in 2006.Justine Schwarte studied chemistry first at the European School of Chemistry, Polymers and Materials (ECPM, Strasbourg, France), and received then an engineer diploma in organic, bioorganic and therapeutic Chemistry from the High National School of Chemistry of Mulhouse (ENSCMu, France). She is pursuing her PhD in Chemistry at the University of Fribourg, Switzerland, about the development of new chemical tools against antimicrobial resistance.
