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E-grāmata: New and Future Developments in Microbial Biotechnology and Bioengineering: Microbial Secondary Metabolites Biochemistry and Applications

Edited by (G.B. Pant National Institute of Himalayan Environment and Sustainable Development, Almora, Uttarakhand, India), Edited by (Department of Chemistry and Biotechnology, Tallinn University of Technology, Estonia)
  • Formāts: PDF+DRM
  • Izdošanas datums: 14-Jun-2019
  • Izdevniecība: Elsevier Science Ltd
  • Valoda: eng
  • ISBN-13: 9780444635112
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New and Future Developments in Microbial Biotechnology and Bioengineering: Microbial Secondary Metabolites Biochemistry and ApplicationsPalielināt
  • Formāts: PDF+DRM
  • Izdošanas datums: 14-Jun-2019
  • Izdevniecība: Elsevier Science Ltd
  • Valoda: eng
  • ISBN-13: 9780444635112
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New and Future Developments in Microbial Biotechnology and Bioengineering: Microbial Secondary Metabolites Biochemistry and Applications examines the areas of biotechnology and chemical engineering, covering aspects of plants, bacteria and machines, and using microbes as factories. The book is aimed at undergraduates, post-graduates and researchers studying microbial secondary metabolites, and is an invaluable reference source for biochemical engineers working in biotechnology, manipulating microbes, and developing new uses for bacteria and fungi. The applications of secondary metabolites in biotechnology, pharmaceuticals, diagnostics and medical device development are extensively covered.

The book integrates the aforementioned frontline branches into an interdisciplinary research work to satisfy those working in biotechnology, chemical engineering, alternative fuel development, diagnostics and pharmaceuticals. Chapters related to important research work on applications of microbial secondary metabolites are written by specialists in the various disciplines from the international community.

  • Compiles the latest developments in the area of microbial secondary metabolites
  • Authored by the top international researchers in this area
  • Includes information related to nearly all areas of a microbial secondary metabolites system

Papildus informācija

This timely guide examines the practical uses and applications of microbial secondary metabolites in biotechnology and bioengineering
List of Contributors ix
1 Wild Mushrooms as Functional Foods: The Significance of Inherent Perilous Metabolites 1(12)
Madhusmita Borthakur
S.R. Joshi
1.1 Introduction
1(1)
1.2 Mushroom and Its Taxonomy
2(1)
1.3 The Toxins and Their Perilous Connections
3(1)
1.4 Prospects and Concerns in Terms of Human Health
4(1)
1.5 Mushrooms as Dietary Supplements
5(2)
1.6 Protein Composition
7(1)
1.7 Lipid Composition
8(1)
1.8 Carbohydrates and Fiber content
8(1)
1.9 Mineral Composition
9(1)
1.10 Conclusion
9(1)
References
10(3)
2 Genetic Manipulation of Secondary Metabolites Producers 13(18)
Ali Asghar Rastegari
Ajar Nath Yadav
Neelam Yadav
2.1 Introduction
13(1)
2.2 Genetic Engineering of the Secondary Metabolic Pathway in Plants
14(4)
2.3 Secondary Metabolites in Actinomycetes by Metabolic Engineering
18(7)
2.4 The Aspergillus nidulans MAPK Module and Secondary Metabolism
25(2)
2.5 Conclusions and Future Scope
27(1)
Acknowledgment
27(1)
References
27(4)
3 Role of Rhizobacterial Secondary Metabolites in Crop Protection Against Agricultural Pests and Diseases 31(24)
Luis Andres Yarzabal
Eduardo J. Chica
3.1 Introduction
31(1)
3.2 Early Uses of Biocontrol Methods in Agriculture
32(1)
3.3 Microbial Secondary Metabolites
33(1)
3.4 Rhizobacterial Secondary Metabolites and Biological Control
34(8)
3.5 Regulation of Secondary Metabolites' Production
42(2)
3.6 Microbial Metabolites and Biopesticides Development
44(1)
3.7 Concluding Remarks
45(1)
References
46(9)
4 Bioengineering of Secondary Metabolites 55(14)
Ali Asghar Rastegari
Ajar Nath Yadav
Neelam Yadav
Nazanin Tataei Sarshari
4.1 Introduction
55(2)
4.2 Gene Duplication in Idiophase
57(1)
4.3 Evolution of New Pathways
58(1)
4.4 Bioengineering of Terpenoids in Plants
59(3)
4.5 Metabolic Engineering and Microbial Biogenesis of Plant Isoprenoids
62(3)
4.6 Enzyme Engineering
65(1)
4.7 Conclusion
66(1)
Acknowledgment
67(1)
References
67(1)
Further Reading
68(1)
5 Advances in Microbial Technology for Upscaling Sustainable Biofuel Production 69(8)
Shachi Shah
V. Venkatramanan
5.1 Introduction
69(1)
5.2 Biomass Feedstocks for Biofuels Production
70(1)
5.3 Downside of First- and Second-Generation Biofuels
71(1)
5.4 Metabolic Engineering and Biofuel Production
72(1)
5.5 Metabolic Pathways for Alcohol-Derived Fuels
73(1)
5.6 Metabolic Pathways for Isoprenoid-Derived Fuels
73(1)
5.7 Metabolic Pathways for Fatty Acid-Derived Fuels
74(1)
5.8 Synthetic Biology and Its Role in Design of Microbial Cell Factories
74(1)
5.9 Engineering Microbes for Tolerance to Next-Generation Biofuels
75(1)
5.10 Conclusion
75(1)
References
76(1)
6 Bioprospecting Actinobacteria for Bioactive Secondary Metabolites From Untapped Ecoregions of the Northwestern Himalayas 77(10)
Qazi Parvaiz Hassan
Aasif Majeed Bhat
Aabid Manzoor Shah
6.1 Introduction to Secondary Metabolites
77(1)
6.2 Introduction to Actinobacteria
78(1)
6.3 Distribution of Actinobacteria
79(1)
6.4 Choice of Actinobacteria as Source of Bioactive Secondary Metabolites
79(1)
6.5 Actinobacteria From Unusual Environments
80(1)
6.6 Northwestern Himalayas as Sources of Bioactive Actinobacteria
81(2)
6.7 Conclusion
83(1)
Acknowledgment
84(1)
References
84(3)
7 Microbial Metabolites: Peptides of Diverse Structure and Function 87(16)
Des Raj Kashyap
7.1 Introduction
87(1)
7.2 Antimicrobial Peptides
88(1)
7.3 Classification of Microbial AMPs
89(4)
7.4 Mechanism of Action
93(2)
7.5 Potential Applications of AMPs
95(1)
7.6 Conclusion
96(1)
References
96(5)
Further Reading
101(2)
8 Agrobacterium rhizogenes Mediated Hairy Root Cultures: A Promising Approach for Production of Useful Metabolites 103(16)
Janhvi Mishra Rawat
Aakriti Bhandari
Manoj Raturi
Balwant Rawat
8.1 Introduction
103(1)
8.2 Agrobacterium and Ri T-DNA Genes
104(1)
8.3 Role of rol Genes
105(1)
8.4 Secondary Metabolite Production
106(4)
8.5 Large-Scale Production of Hairy Roots
110(1)
8.6 Liquid-Phase Bioreactors
111(2)
8.7 Gas Phase Bioreactors
113(1)
8.8 Hybrid Bioreactors
113(1)
8.9 Parameters That Affect Productivity
113(1)
8.10 Conclusion and Future Prospects
114(1)
References
114(5)
9 Unleashing Extremophilic Metabolites and Its Industrial Perspectives 119(12)
Balasubramanian Cibichakravarthy
Siddarthan Venkatachalam
Solai Ramatchandirane Prabagaran
9.1 Introduction
119(1)
9.2 Marine Microbial Metabolites Derived From Benthic Environment
120(1)
9.3 Marine Sponge-Microbial Symbionts
121(1)
9.4 Stromatolites: Potential Novel Source for Future Biotechnology
121(2)
9.5 Polyhydroxyalkanoate-Producing Free-Living Marine Bacteria
123(1)
9.6 Stress Acclimatization of PHA-Producing Bacteria
124(1)
9.7 Production of Polyhydroxyalkanoate by Halophilic Bacteria
124(2)
9.8 Role of PHA Synthase in Halophiles
126(1)
9.9 Concluding Remarks
127(1)
References
127(3)
Further Reading
130(1)
10 Hybrid Bioactive Products and Combinatorion Biosynthesis 131(10)
Mohd Sajjad Ahmad Khan
Mohd Musheer Altaf
10.1 Introduction
131(1)
10.2 Need of Combinatorial Biosynthesis
132(1)
10.3 Precursor-Directed Combinatorial Biosynthesis
132(2)
10.4 Enzyme-Level Combinatorial Biosynthesis
134(2)
10.5 Pathway-Level Combinatorial Biosynthesis
136(1)
10.6 Conclusion
137(1)
Acknowledgment
137(1)
References
137(4)
11 Rubromycins: A Class of Telomerase Inhibitor Antibiotics Produced by Streptomyces spp. 141(10)
Ali Zineddine Boumehira
Hocine Hacene
Hesham A. El-Enshasy
11.1 Introduction
141(1)
11.2 Telomeres, Telomerase, and Cancer
142(1)
11.3 Rubromycins: A Class of Molecules Telomerase Activity Inhibition
143(1)
11.4 Mode of Action of Rubromycins Human Telomerase Inhibition
144(1)
11.5 Streptomyces spp.: The Biofactories for Human Telomerase Inhibitors Production
144(1)
11.6 Biosynthesis of Rubromycins
145(1)
11.7 Bioprocess of Rubromycins Production
146(1)
References
147(4)
12 Regulation by Metal Ions 151(14)
Shalini Singh
Robinka Khajuria
12.1 Introduction
151(2)
12.2 Regulatory Mechanisms
153(1)
12.3 Role of Specific Molecules in Controlling Biosynthetic Pathways
154(2)
12.4 Metal Ions in the Synthesis of Organic Acids
156(1)
12.5 Metal Ions in the Synthesis of Siderophores
157(1)
12.6 Metal Ions in the Synthesis of Microbial Pigments
158(1)
12.7 Metal Ions in the Synthesis of Vascular Permeability Factor
158(1)
12.8 Metal Ions in the Synthesis of Hydrogen Cyanide
159(1)
12.9 Conclusion
159(1)
References
159(6)
13 Citric Acid Cycle Regulation: Back Bone for Secondary Metabolite Production 165(18)
Punit Kumar
Kashyap Kumar Dubey
13.1 History
166(2)
13.2 Citric Acid Cycle: Process and Regulation
168(4)
13.3 Citric Acid Cycle as Biosynthetic Precursors
172(4)
13.4 Example of Synthesis of Metabolites Through Intermediates of Citric Acid Cycle
176(3)
13.5 Conclusion
179(1)
References
180(3)
14 Resistance in Pathogenic Microorganisms 183(10)
Saba Siddiqui
14.1 Resistance in Bacteria
183(3)
14.2 Resistance in Fungi
186(2)
14.3 Antifungal Resistance From Environmental Origin
188(1)
14.4 Resistance in Viruses
188(2)
References
190(3)
15 Hybrid Approach for Transformation for Betulin (an Anti-HIV Molecule) 193(12)
Dhirendra Kumar
Kashyap Kumar Dubey
15.1 Background of Betulin
193(2)
15.2 Main Sources of Triterpenes
195(1)
15.3 Applications
196(1)
15.4 Value Addition Using the Hybrid Approach
197(1)
15.5 Key Strategies for Adding Value
198(1)
15.6 Hybrid Approach to Develop Betulin Derivatives
199(1)
15.7 Issues in Chemical Synthesis
200(1)
15.8 Conclusion
200(1)
Acknowledgments
201(1)
References
201(2)
Further Reading
203(2)
16 Producers of Bioactive Compounds 205(18)
Arvind Kumar
Ram Naraian
16.1 Introduction
205(2)
16.2 Bioactive Compounds
207(1)
16.3 Major Classes of Bioactive Compounds
207(1)
16.4 Criteria for the Selection of an Ideal Bioactive Compound
208(1)
16.5 Diverse Biological Activities of Bioactive Compounds
208(1)
16.6 Sources of Bioactive Compounds
208(1)
16.7 Plants as the Sources of Bioactive Compounds
209(1)
16.8 Invertebrates as the Sources of Bioactive Compounds
209(1)
16.9 Microbial Producers of Bioactive Compounds
210(1)
16.10 Bacteria as Producers of Bioactive Compounds
211(3)
16.11 Fungi as Producers of Bioactive Compounds
214(2)
16.12 Algae as Producers of Bioactive Compounds
216(2)
16.13 Conclusion
218(1)
References
218(5)
17 Bioremediation of Organic and Inorganic Pollutants Using Microalgae 223(14)
Madhumanti Mondal
Gopinath Halder
Gunapati Oinam
Thingujam Indrama
Onkar Nath Tiwari
17.1 Introduction
223(1)
17.2 Inorganic Pollutants
224(3)
17.3 Organic Pollutants
227(3)
17.4 Role of Biosurfactants in the Bioremediation
230(1)
17.5 Emerging Pollutants
231(1)
17.6 Conclusion
231(1)
References
232(3)
Further Reading
235(2)
18 Secondary Metabolites From Endophytic Fungi and Their Biological Activities 237(22)
M. Vasundhara
M. Sudhakara Reddy
Anil Kumar
18.1 Introduction
237(1)
18.2 Endophytic Fungal Diversity
238(1)
18.3 Secondary Metabolites
238(14)
18.4 Conclusions
252(1)
References
252(7)
19 Regulation and Role of Metal Ions in Secondary Metabolite Production by Microorganisms 259(20)
Manish Kumar Dubey
Mukesh Meena
Mohd. Aamir
Andleeb Zehra
Ram Sanmukh Upadhyay
19.1 Introduction
259(4)
19.2 Manganese
263(1)
19.3 Copper
264(1)
19.4 Nickel
265(1)
19.5 Calcium
265(1)
19.6 Cadmium
266(1)
19.7 Zinc
266(2)
19.8 Cobalt
268(1)
19.9 Iron
269(1)
19.10 Rare-Earth Elements
269(1)
19.11 Other Metals
270(1)
19.12 Conclusion and Future Prospect
270(1)
References
271(6)
Further Reading
277(2)
20 Metabolic Engineering to Synthetic Biology of Secondary Metabolites Production 279(42)
Ajar Nath Yadav
Divjot Kour
Kusam Lata Rana
Neelam Yadav
Bhanumati Singh
Vinay Singh Chauhan
Ali Asghar Rastegari
Abd El-Latif Hesham
Vijai Kumar Gupta
20.1 Introduction
279(1)
20.2 Secondary Metabolites-Producing Microbes
280(4)
20.3 Discovery of Novel Microbes Producing Secondary Metabolites
284(2)
20.4 The Functional Genomics of Secondary Metabolites-Producing Microbes
286(2)
20.5 Biodiversity of Secondary Metabolites-Producing Microbes
288(7)
20.6 Distributions of Secondary Metabolites-Producing Microbes
295(10)
20.7 Synthetic Biology for Secondary Metabolites Production
305(4)
20.8 Biotechnological Applications of Secondary Metabolites
309(1)
20.9 Conclusion and Future Prospects
310(1)
Acknowledgment
311(1)
References
311(10)
21 Microbial Enzymes as Control Agents of Diseases and Pests in Organic Agriculture 321(12)
Tassia C. Confortin
Stefani S. Spannemberg
Izelmar Todero
Luciana Luft
Thiarles Brun
Eliana A. Alves
Raquel C. Kuhn
Marcio A. Mazutti
21.1 Introduction
321(1)
21.2 Production of Microbial Enzymes
322(2)
21.3 Enzyme Purification
324(1)
21.4 Role of Enzymes in Inducing Plant Resistance to Insect Attack
324(1)
21.5 Antioxidant Enzymes
325(1)
21.6 Types of Enzymes and Their Application in Agriculture for Pest Control
326(3)
21.7 Final Conclusion
329(1)
References
329(3)
Further Reading
332(1)
22 Secondary Metabolites: Metabolomics for Secondary Metabolites 333(12)
Gaurav Raj Dwivedi
Brijesh Singh Sisodia
Shikha
22.1 Introduction
333(1)
22.2 Secondary Metabolites and Synthetic Biology
334(1)
22.3 Primary Metabolites
334(1)
22.4 Secondary Metabolite
335(1)
22.5 Genome and Genomics
335(1)
22.6 Proteome and Proteomics
335(1)
22.7 Synthetic Biology
335(1)
22.8 Metabolomics and Synthetic Biology: How to Engineer the Microbes
336(1)
22.9 Discovery of Secondary Metabolites: How to Discover Secondary Metabolites Through Metabolomics
337(1)
22.10 Production of Secondary Metabolites
338(1)
22.11 Role of Metabolomics in Identification of the Bottleneck in Engineered Pathway
339(2)
22.12 Conclusion and Future Perspectives
341(1)
Acknowledgments
341(1)
Conflict of Interest
342(1)
References
342(3)
23 Solid-State Fermentation Strategy for Microbial Metabolites Production: An Overview 345(10)
Neha Srivastava
Manish Srivastava
P.W Ramteke
P.K. Mishra
23.1 Introduction
345(1)
23.2 History of SSF
346(1)
23.3 Common Characteristics of Solid-State Fermentation
347(1)
23.4 Analysis of Substrate Selection for Solid-State Fermentation
348(1)
23.5 Microorganisms and Growth Kinetics for Solid-State Fermentation
349(1)
23.6 Physicochemical Parameters for Solid-State Fermentation
350(1)
23.7 Bioreactor for the Solid-State Fermentation
351(1)
23.8 Conclusion
352(1)
Acknowledgement
352(1)
References
352(3)
Index 355
Dr Vijai G. Gupta is an Assistant Professor of Biotechnology at MITS University of India. Currently he is working as Research Scientist at National University of Ireland in Galway. Dr. Guptas present work is focused on the development and optimization of novel Enzyme-based bioconversion systems for biorefining and bioenergy. He has been honored with several awards, including the prestigious Indian ICAR Senior Research Fellowship and Indian Young Scientist Award. He has submitted 33 new fungal nucleotide sequences and deposited 147 fungal strains in International databases. His work with Fusarium spp., Colletotrichum gloeosporioides, Penicillium spp. and Trichoderma spp. is augmented by contributions to biotechnological development, molecular diversity, secondary metabolites and industrial applications Dr. Gupta is the editor-in-chief of the International Journal of Plant Pathology and a regional editorial board member of 8 other respected journals. He is the author of 40 journal articles and 27 book chapters. Gupta has also written and edited books and series from reputed publishers, including CRC Press, Taylor and Francis, USA; Springer, USA; Elsevier, USA; Nova Science Publisher, USA and LAP Lambert Academic Publishing, Germany. Dr. Anita Pandey is a Microbiologist at the G.B. Pant National Institute of Himalayan Environment and Sustainable Development in Almora, Uttarakhand, India. Her research focuses on the bioprospection of microbial diversity in the Indian Himalayan region (IHR). Specifically, her research areas of interest have included extremophiles, rhizosphere, biodegradation, fermented foods, water microbes, and plant-based antimicrobials. She has also developed microbial formulations for conservation of medicinal plant species and established a microbial culture collection in her laboratory. MSc, PhD and Postdoc scholars work in her research group.

Dr. Pandey has several recognitions to her credit, such as the National Young Woman Bioscientist Award by DBT, Govt. of India, New Delhi and Vishisht Mahila Vaigyanik Sammaan (Eminent Woman Scientist Recognition) by USERC, Govt. of Uttarakhand, India.
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