The potential impact of work being conducted in genomics, proteomics, and metabolomics upon clinical practice for gynecologists is immense but not yet completely appreciated. This groundbreaking text from international experts examines the newest topics on the perinatal agenda and gives clinicians a real look into the future via the newest methodologies.
| Introduction: Why do we need omics and systems biology? |
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| Contributors |
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SECTION I PREGNANCY COMPLICATIONS: SETTING THE SCENE |
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1 The mother: Adaptation to pregnancy and normal metabolism |
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2 | (5) |
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2 Maternal and fetal normal and abnormal nutrition |
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7 | (5) |
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3 Great obstetrical syndromes: It's all in the placenta |
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12 | (6) |
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4 Normal and abnormal fetal growth |
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18 | (5) |
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5 Preterm labor and birth |
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23 | (5) |
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6 Gestational diabetes mellitus |
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28 | (6) |
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34 | (6) |
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40 | (6) |
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9 Maternal health: Immediate, short-, and long-term complications following pregnancy |
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46 | (10) |
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10 The fetus and the neonate: Immediate, short-, and long-term impact |
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56 | (4) |
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11 Cost of pregnancy complications related to noncommunicable diseases and cost effectiveness of interventions to address them |
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60 | (14) |
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SECTION II TOWARDS PREDICTION AND PREVENTION |
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12 Integrated system biology approaches to fetal medicine problems |
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74 | (7) |
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13 Omics and female reproduction |
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81 | (4) |
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14 Maternal genome and pregnancy outcomes |
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85 | (5) |
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15 Placental development and omics |
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90 | (5) |
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16 Placental metabolomics in obese pregnancies |
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95 | (3) |
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17 Methylome and epigenetic markers |
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98 | (4) |
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18 Microbiome and pregnancy complications |
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102 | (5) |
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19 Small noncoding RNAs as biomarkers for pregnancy complications |
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107 | (5) |
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20 Urine metabolomics and proteomics in prenatal health |
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112 | (13) |
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21 Metabolomics and perinatal complications |
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125 | (8) |
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22 Metabolomics in normal and pathologic pregnancies |
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133 | (6) |
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23 Metabolomics in amniotic fluid |
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139 | (10) |
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Alexandra-Maria Michaelidou |
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Apostolos P. Athanasiadis |
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24 Omics and coagulation disorders in pregnancy |
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149 | (7) |
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25 Omics and perinatal medicine: Preeclampsia |
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156 | (16) |
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26 Single nucleotide polymorphisms and pregnancy complications |
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172 | (2) |
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27 Metabolomics and perinatal cardiology |
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174 | (3) |
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28 Metabolomics and human breast milk: A unique and inimitable food for infants |
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177 | (4) |
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29 Neurodevelopment and placental omics |
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181 | (4) |
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Ariadne Malamitsi-Puchner |
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30 Early life complications, placental genomics, and risk for neurodevelopmental disorders in offspring |
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185 | (7) |
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31 Metabolomics and perinatal asphyxia |
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192 | (12) |
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32 Environment, pregnancy complications, and omics |
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204 | (5) |
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33 Sleep and pregnancy complications |
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209 | (5) |
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34 Maternal plasma cell-free DNA screening: Basic science and applications |
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214 | (4) |
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35 Maternal plasma cell-free DNA screening: Integration into clinical practice |
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218 | (5) |
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223 | (7) |
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37 Whole exome and whole genome sequencing |
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230 | (9) |
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| Index |
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239 | |
Prof. Moshe Hod is Director of the Mor Comprehensive Women's Health Care Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel, President of the European Association of Perinatal Medicine, and Chairman of the FIGO Hyperglycemia in Pregnancy Working Group. Eduard Gratacos is Head and Professor of Maternal-Fetal Medicine at Hospitals Clķnic de Barcelona & Sant Joan de Déu, Barcelona, Spain. Vincenzo Berghella is Professor and Director, Division of Maternal-Fetal Medicine at Thomas Jefferson University, Philadelphia, PA, USA, and President of the Society for Maternal-Fetal Medicine. Mary E D'Alton is Willard C. Rappleye Professor of Obstetrics & Gynecology and Director of Services, Sloane Hospital for Women, and Chair of the Department of Obstetrics & Gynecology, Maternal-Fetal Medicine, Columbia University Medical Center, New York, NY, USA, and is a past president of the Society for Maternal-Fetal Medicine. Prof. Gian Carlo Di Rezo is Director of Perinatal and Reproductive Medicine Center and Midwifery School, University Hospital Perugia, Italy and Director of Permanent International and European School of Perinatal and Reproductive Medicine, Florence, Italy. Prof. Vassilios Fanos is Professor of Pediatrics and Director of Neonatal Intensive Care Unit, University of Cagliari, Cagliari, Italy.
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