E-grāmata: Non-Clinical Vascular Infusion Technology, Volume I: The Science

Preface There are many pharmaceuticals on the market or undergoing clinical trials that require intravenous infusion, for either short or longer periods, intermittently or continuously, and so this book should be of interest to those in pharmaceutical research and development, as well as in other research areas. These applications include chemotherapy and the treatment of various diseases such as HIV, hepatitis C, and cardiovascular disease, as well as during and following problematical surgical procedures. It is a regulatory and ethical requirement that these pharmaceuticals first be tested on both rodents and non-rodents by the clinical route, and so the range of pre-clinical experimental models is covered. The technique of prolonged intravenous delivery in conscious, free-moving animal models has also broadened the opportunities to study and evaluate the safety and efficacy of those products that have limiting biological or chemical properties such as half-life and formulation issues. In 2000 the first book covering pre-clinical infusion techniques was published by Taylor & Francis (Handbook of Pre-Clinical Continuous Intravenous Infusion, Healing and Smith, editors) and this has become the singular reference source for this technology up to the present time. However, it is now recognised that a number of the techniques have been refined since that time, and also that new and improved equipment has been developed--Provided by publisher. Intravenous infusion is a necessary mode of delivery for many pharmaceuticals currently on the market or undergoing clinical trials. The technique of prolonged intravenous delivery in conscious, free-moving animal models has broadened the opportunity to study and evaluate the safety and efficacy of these therapeutic products. For the first time, the collective sciences involved in the understanding of this mode of drug delivery are brought together in one publication.Non-Clinical Vascular Infusion Technology, Volume I: The Science covers the scientific principles behind the delivery systems, from both physical and physiological standpoints. The book addresses body fluid dynamics, describes the scientific processes necessary to understand the various aspects of the physico-chemical issues relating to vascular infusion delivery, and discusses vascular infusion dynamics. It also considers all the essential elements of the preparation of a formulation intended for vascular delivery as well as assessment of compatibility of the formulation with the dosing apparatus. This volume, along with Volume II: The Techniques, provides a foundation of knowledge on infusion technology and its importance for safe clinical use of substances via this route of delivery.FeaturesIdentifies and shares best practices for non-clinical vascular infusionPresents modern practices and procedures in line with up-to-date equipment developmentOffers recommendations for in-life assessments in order to monitor the success or problems with the vascular infusion deliveryMakes comparisons with human data in many areas