The book provides an in-depth and comprehensive overview of the essential role of non-coding RNAs (ncRNAs) in bone formation. In combination with researches from multiple scholars in this field, the book reviews the mechanisms of ncRNA-related bone diseases, as well as the potential applications of RNA synthesis technology in bone disorder treatments. This volume covers the following topics: 1) basic introduction of non-coding RNA and bone development, how 2) microRNAs and 3) long noncoding RNAs (LncRNAs) regulate bone formation, 4) how ncRNAs and the corresponding pathways participate in bone metabolism diseases, 5) RNA synthesis technology and the possible RNA therapies in bone disease. Researchers and students in the fields of human genetics, human physiology, developmental biology and biomedical engineering, as well as professionals and scientists in Orthopedics, will particularly find this book helpful.
Preface.- Part I MicroRNAs and Bone.
Chapter 1 MicroRNAs and
Osteoporosis.
Chapter 2 MicroRNAs and the Diagnosis of Osteoporosis.-
Chapter 3 MicroRNAs and Osteoarthritis.- Chapter 4 Mechanosensitive miRNAs
and Bone Formation.- Part II Long non-coding RNAs and Bone.
Chapter 5 Roles
and Mechanism of Long Noncoding RNAs in Bone Diseases.- Chapter 6 LncRNAs
that Regulate Oosteoblast Function and Bone Formation.- Part III RNA
Synthesis Technology and RNA Therapy in Bone Diseases.- Chapter 7 Synthetic
Technology of Non-coding RNAs Used in Bone Disease Research and
Therapeutics.
Chapter 8 RNA Therapy in Bone Diseases.
Dr. Airong QIAN is a professor at School of Life Sciences, Northwestern Polytechnical University, Xian, China. She serves as the director of NPU-UAB International Joint Laboratory of Bone Metabolism at this University.
