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Novel Delivery Systems for Transdermal and Intradermal Drug Delivery [Hardback]

Edited by (School of Pharmacy, Queens University, Belfast, UK), Edited by (School of Pharmacy, Queens University, Belfast, UK)
  • Formāts: Hardback, 296 pages, height x width x depth: 252x175x20 mm, weight: 603 g
  • Sērija : Advances in Pharmaceutical Technology
  • Izdošanas datums: 18-Sep-2015
  • Izdevniecība: John Wiley & Sons Inc
  • ISBN-10: 1118734513
  • ISBN-13: 9781118734513
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Novel Delivery Systems for Transdermal and Intradermal Drug DeliveryPalielināt
  • Formāts: Hardback, 296 pages, height x width x depth: 252x175x20 mm, weight: 603 g
  • Sērija : Advances in Pharmaceutical Technology
  • Izdošanas datums: 18-Sep-2015
  • Izdevniecība: John Wiley & Sons Inc
  • ISBN-10: 1118734513
  • ISBN-13: 9781118734513
Citas grāmatas par šo tēmu:
Permanent link: https://www.kriso.lv/db/9781118734513.html
Keywords:
This research book covers the major aspects relating to the use of novel delivery systems in enhancing both transdermal and intradermal drug delivery. It provides a review of transdermal and intradermal drug delivery, including the history of the field and the various methods employed to produce delivery systems from different materials such as device design, construction and evaluation, so as to provide a sound background to the use of novel systems in enhanced delivery applications.
Furthermore, it presents in-depth analyses of recent developments in this exponentially growing field, with a focus on microneedle arrays, needle-free injections, nanoparticulate systems and peptide-carrier-type systems. It also covers conventional physical enhancement strategies, such as tape-stripping, sonophoresis, iontophoresis, electroporation and thermal/suction/laser ablation Discussions about the penetration of thestratum corneum by the various novel strategies highlight the importance of the application method. Comprehensive and critical reviews of transdermal and intradermal delivery research using such systems focus on the outcomes ofin vivoanimal and human studies. The book includes laboratory, clinical and commercial case studies featuring safety and patient acceptability studies carried out to date, and depicts a growing area for use of these novel systems is in intradermal vaccine delivery. The final chapters review recent patents in this field and describe the work ongoing in industry.
About the Editors xiii
Contributors xv
Advances in Pharmaceutical Technology: Series Preface xvii
Preface xix
1 Introduction
1(40)
Gary P.J. Moss
1.1 The Subcutis (Subcutaneous Fat Layer)
1(1)
1.2 The Dermis
2(1)
1.3 Skin Appendages
2(1)
1.4 The Subcutaneous Sensory Mechanism
3(2)
1.5 The Epidermis
5(1)
1.6 The stratum germinativum
5(1)
1.7 The stratum spinosum
5(1)
1.8 The stratum granulosum
6(1)
1.9 The stratum lucidum
6(1)
1.10 The stratum corneum
6(5)
1.10.1 Routes of Absorption
9(1)
1.10.2 Transdermal Permeation -- Mechanisms of Absorption
9(2)
1.11 Theoretical Considerations
11(2)
1.12 Physicochemical Properties of the Penetrant
13(3)
1.12.1 Partition Coefficient
13(1)
1.12.2 Molecular Size and Shape
14(1)
1.12.3 Applied Concentration/Dose
15(1)
1.12.4 Solubility and Melting Point
15(1)
1.12.5 Ionisation
15(1)
1.12.6 Physiological Factors Affecting Percutaneous Absorption
16(1)
1.13 Physiological Properties of the Skin
16(3)
1.13.1 Skin Condition
16(1)
1.13.2 Skin Hydration and Occlusion
17(1)
1.13.3 Skin Age
17(1)
1.13.4 Regional Variation (Body Site)
18(1)
1.13.5 Race
19(1)
1.13.6 Skin Temperature
19(1)
1.14 Vehicle Effects
19(1)
1.15 Modulation and Enhancement of Topical and Transdermal Drug Delivery
20(21)
1.15.1 Chemical Modulation of Permeation
21(5)
1.15.2 Physical Methods of Enhancement
26(15)
2 Application of Spectroscopic Techniques to Interrogate Skin
41(16)
Jonathan Hadgraft
Rita Mateus
Majella E. Lane
2.1 Introduction
41(1)
2.2 Vibrational Spectroscopic Methods
42(4)
2.3 Electronic Spectroscopic Methods
46(2)
2.3.1 UV and Fluorescence
46(1)
2.3.2 Nuclear Magnetic Resonance
47(1)
2.4 Miscellaneous Spectroscopic Methods
48(2)
2.4.1 Opto-Thermal Transient Emission Radiometry
48(1)
2.4.2 Electron Spin Resonance
48(1)
2.4.3 Impedance Spectroscopy
49(1)
2.4.4 Laser-Induced Breakdown Spectroscopy
49(1)
2.4.5 Photoacoustic Spectroscopy
50(1)
2.4.6 Mass Spectrometry Imaging
50(1)
2.5 Conclusions and Future
50(7)
3 Analysis of the Native Structure of the Skin Barrier by Cryo-TEM Combined with EM-Simulation
57(14)
Lars Norlen
3.1 Introduction
57(1)
3.2 Our Approach: In Situ Biomolecular Structure Determination in Near-Native Skin
58(9)
3.2.1 Step 1: Cryo-Electron Microscopy of Vitreous Sections
60(6)
3.2.2 Steps 2--3: Molecular Model Building and Electron Microscopy Simulation
66(1)
3.2.3 Step 4: Confrontation of Observed Data with Simulated Data
66(1)
3.3 Molecular Organisation of the Horny Layer's Fat Matrix
67(1)
3.4 Molecular Organisation of the Horny Layer's Keratin Filament Matrix
67(1)
3.5 Final Remark
68(3)
4 Intradermal Vaccination
71(26)
Marija Zaric
Adrien Kissenpfennig
4.1 Vaccination
71(2)
4.1.1 Disadvantages Associated with Conventional Vaccination
72(1)
4.2 Dendritic Cells Immunobiology
73(1)
4.3 Skin Anatomy and Physiology
74(2)
4.3.1 The Role of Skin in Vaccine Delivery
75(1)
4.4 The Skin Dendritic Cell Network
76(6)
4.4.1 Langerhans Cells and the `Langerhans Cell Paradigm'
76(1)
4.4.2 Dermal Dendritic Cell Network
77(2)
4.4.3 Dendritic Cell Subsets in the Skin-Draining Lymph Node
79(1)
4.4.4 Human Dendritic Cells in the Skin
80(1)
4.4.5 The Role of Skin Dendritic Cells Subsets in Transdermal Immunisation
81(1)
4.5 The DTR-DT Depletion System
82(2)
4.5.1 Langerin-DTR Mouse Models
83(1)
4.6 Dendritic Cells and the Differentiation of T Lymphocytes
84(4)
4.6.1 CD8+ T Cell Activation
85(1)
4.6.2 CD4+ T Cell Polarisation
85(3)
4.7 Summary
88(9)
5 Film-Forming and Heated Systems
97(28)
William J. McAuley
Francesco Caserta
5.1 Film-Forming Systems
97(10)
5.1.1 The Design of Film-Forming Systems
98(1)
5.1.2 Advantages of Using Film-Forming Systems for Drug Delivery
99(2)
5.1.3 Production of a Supersaturated State
101(2)
5.1.4 Use with Chemical Penetration Enhancers
103(2)
5.1.5 Advantages of Film-Forming Systems for Patient Use
105(1)
5.1.6 Therapeutic Applications
105(2)
5.2 Heated Systems
107(9)
5.2.1 Mechanisms of Drug Penetration Enhancement
107(1)
5.2.2 Partitioning
108(2)
5.2.3 Effects of Heat on Skin
110(1)
5.2.4 Dermal Clearance
111(1)
5.2.5 The Effects of Heat on the Permeation of Drugs Across Skin
112(1)
5.2.6 Strategies for Generating Heat
113(2)
5.2.7 Therapeutic Applications
115(1)
5.3 Conclusions
116(9)
6 Nanotechnology-Based Applications for Transdermal Delivery of Therapeutics
125(22)
Venkata K. Yellepeddi
6.1 Introduction
125(4)
6.1.1 Skin Structure
126(1)
6.1.2 Skin Sites for Nanoparticle Delivery
127(1)
6.1.3 Skin as a Barrier for Nanoparticle Penetration
128(1)
6.1.4 Physicochemical Characteristics of NPs for Penetration through Skin
129(1)
6.2 Nanocarriers for Topical and Transdermal Delivery
129(8)
6.2.1 Polymeric Nanoparticles
130(4)
6.2.2 Lipid Based Nanocarriers
134(1)
6.2.3 Metallic and Mineral Nanoparticles
135(2)
6.2.4 Carbon-Based Nanomaterials
137(1)
6.3 Interactions of Nanoparticles with the Skin
137(1)
6.4 Limitations of Nanotechnology for Skin Delivery
138(1)
6.5 Conclusions
139(8)
7 Magnetophoresis and Electret-Mediated Transdermal Delivery of Drugs
147(16)
Abhijeet Maurya
Cui Lili
S. Narasimha Murthy
7.1 Introduction
147(2)
7.2 Physical Permeation Enhancement Techniques
149(1)
7.3 Magnetophoresis
150(5)
7.3.1 Drug Delivery Applications
151(1)
7.3.2 Mechanism of Permeability Enhancement
152(2)
7.3.3 Magnetophoretic Transdermal Patch
154(1)
7.3.4 Conclusion
154(1)
7.4 Electret-Mediated Drug Delivery
155(8)
7.4.1 Electrets for Cutaneous Drug Delivery
156(2)
7.4.2 Electret Layer in a Patch
158(1)
7.4.3 Mechanism of Permeability Enhancement
158(1)
7.4.4 Conclusion
159(4)
8 Microporation for Enhanced Transdermal Drug Delivery
163(16)
Thakur Raghu Raj Singh
Chirag Gujral
8.1 Introduction
163(1)
8.2 High-Pressure Gas or Liquid Microporation
164(2)
8.3 Ultrasound (Phonophoresis and Sonophoresis) Microporation
166(2)
8.4 Iontophoresis
168(1)
8.5 Electroporation
169(1)
8.6 Laser Microporation
170(1)
8.7 Thermal Microporation
171(2)
8.8 RF Microporation
173(1)
8.9 Microneedles
173(1)
8.10 Conclusion
174(5)
9 Microneedle Technology
179(30)
Helen L. Quinn
Aaron J. Courtenay
Mary-Carmel Kearney
Ryan F. Donnelly
9.1 Introduction
179(3)
9.2 MN Materials and Fabrication
182(3)
9.3 MN-Mediated Drug Delivery
185(3)
9.3.1 Combinational Approaches
187(1)
9.4 MN Vaccination
188(3)
9.4.1 Polymeric MNs and Vaccination
188(1)
9.4.2 Solid MNs and Vaccination
189(1)
9.4.3 Hollow MNs and Vaccination
190(1)
9.4.4 MN Vaccination Moving Forwards
190(1)
9.5 Further MN Applications
191(3)
9.5.1 Therapeutic Drug Monitoring
192(1)
9.5.2 Cosmetic Applications
193(1)
9.5.3 Other Potential Applications
194(1)
9.6 Patient Factors Relating to MN Use
194(4)
9.6.1 Effects of MN Insertion on the Skin
194(2)
9.6.2 Patient Safety
196(1)
9.6.3 Acceptability to Patients and Healthcare Providers
197(1)
9.6.4 Patient Application
197(1)
9.7 The Next Steps in MN Development
198(3)
9.7.1 Manufacturing Considerations
199(1)
9.7.2 Regulatory Considerations
199(1)
9.7.3 Commercialisation of MN Technologies
200(1)
9.8 Conclusion
201(8)
10 Intradermal Delivery of Active Cosmeceutical Ingredients
209(34)
Andrzej M. Bugaj
10.1 Introduction
209(1)
10.2 Emulsions
210(6)
10.2.1 Microemulsions
211(1)
10.2.2 Nanoemulsions
212(1)
10.2.3 Quick-Breaking Emulsions
213(1)
10.2.4 Pickering Emulsions
214(1)
10.2.5 Gel Emulsions
214(1)
10.2.6 Liquid Crystal Emulsions
214(1)
10.2.7 Multiple Emulsions
215(1)
10.3 Vesicular Systems
216(6)
10.3.1 Liposomes
216(5)
10.3.2 Niosomes
221(1)
10.3.3 Sphingosomes
221(1)
10.3.4 Multiwalled Delivery Systems
221(1)
10.4 Solid Particulate Systems
222(7)
10.4.1 Microparticles
222(3)
10.4.2 Solid Nanoparticles
225(3)
10.4.3 Fullerenes
228(1)
10.4.4 Cyclodextrins
228(1)
10.4.5 Fibrous Matrices
229(1)
10.5 Cosmetic Foams
229(1)
10.6 Cosmetic Patches
230(1)
10.7 Cosmeceuticals: The Future
230(13)
11 Commercial and Regulatory Considerations in Transdermal and Dermal Medicines Development
243(16)
Marc. B. Brown
Jon Lenn
Charles Evans
Sian Lim
11.1 Introduction
243(2)
11.2 Dermal and Transdermal Product/Device Development
245(8)
11.2.1 Drug Candidate Selection
246(1)
11.2.2 Dosage/Device Form
246(2)
11.2.3 Pre-formulation and Formulation/Device Development
248(2)
11.2.4 Performance Testing
250(3)
11.3 Product Scale-Up and Process Optimisation, Validation and Stability Testing
253(1)
11.3.1 Product Scale-Up, Process Optimisation and Specification Development
253(1)
11.3.2 Analytical Method Validation
253(1)
11.3.3 ICH Stability Testing
254(1)
11.4 The Commercial Future of Transdermal Devices
254(5)
Index 259
Dr Ryan Donnelly is Reader in Pharmaceutics at Queen's University Belfast. Dr Donnelly's research is centred on design and physicochemical characterisation of advanced polymeric drug delivery systems for transdermal and topical drug delivery, with a strong emphasis on improving therapeutic outcomes for patients. He is also a technical director at Swedish Pharma AB. Still at a relatively early stage of his career, he has authored over 300 peer-reviewed publications, including 3 patent applications, 3 textbooks, 16 book chapters and approximately 100 full papers. Hes the holder of many awards including the current GSK Emerging Scientist Award. Dr Raj Thakur is Lecturer in Pharmaceutics at Queen's University Belfast. He obtained his PhD in polymer science in 2009 from Queens University Belfast and his MSc in drug delivery in 2006 from University Science Malaysia. He has a BSc in Pharmacy from Jawaharlal Nehru Technological University, India. Dr Thakur's research interests are in development and evaluation of novel in situ forming controlled release implants and ocular and transdermal drug delivery using novel minimally-invasive devices. He has published a textbook and over 30 scientific papers.