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E-grāmata: Oncological Functional Nutrition: Phytochemicals and Medicinal Plants

Edited by (Food Science Laboratory, Chemical Engineering Faculty, Universidad Autónoma de Yucatan, Mérida, Mexico), Edited by (Universidad Autónoma de Yucatan, Merida, Mexico)
  • Formāts: PDF+DRM
  • Izdošanas datums: 20-Aug-2021
  • Izdevniecība: Academic Press Inc
  • Valoda: eng
  • ISBN-13: 9780128198292
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Oncological Functional Nutrition: Phytochemicals and Medicinal PlantsPalielināt
  • Formāts: PDF+DRM
  • Izdošanas datums: 20-Aug-2021
  • Izdevniecība: Academic Press Inc
  • Valoda: eng
  • ISBN-13: 9780128198292
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Oncological Functional Nutrition: Phytochemicals and Medicinal Plants presents the anticancer activities, metabolism, mechanism of action, doses, and sources of various phytochemicals and medicinal plants.

Broken into five parts, this book addresses cancer epidemiology, molecular and therapeutic bases of cancer, macro and micronutrients in cancer prevention and treatment, phytochemicals in the cancer treatment, and medical plants as potential functional foods or resources for the obtention of metabolites with anticancer activity.

Written for nutritionists, food scientists, health professionals, oncologists, endocrinologists, natural product chemists, ethnobotanists, chemists, pharmacists, biochemists, and students studying relating fields, Oncological Functional Nutrition: Phytochemicals and Medicinal Plants will be a useful reference for those interested in learning more about functional nutrition and cancer.

  • Discusses functional nutrition as alternative therapy
  • Provides recommendations and intervention strategies related to the consumption of phytochemicals, food, and medicinal plants
  • Addresses cancer epidemiology, the molecular and therapeutic bases of cancer, phytochemicals in the cancer treatment, and medical plants
List of contributors ix
1 Cancer epidemiology 1(40)
Yelda A. Leal
1.1 Introduction
1(1)
1.2 Theoretical framework
1(2)
1.2.1 Global cancer epidemiology
1(1)
1.2.2 Related factors to cancer
2(1)
1.3 Endogenous exposure
3(4)
1.3.1 Cancer susceptibility
3(1)
1.3.2 Spontaneous mutations
3(1)
1.3.3 Epigenetics
4(1)
1.3.4 Hereditary cancer
4(1)
1.3.5 Chronic inflammation
5(2)
1.4 Exogenous exposure
7(9)
1.4.1 Infections
7(1)
1.4.2 Environmental pollutants
8(2)
1.4.3 Diet
10(1)
1.4.4 Carcinogenesis by the process of food
11(2)
1.4.5 Supplement and multivitamins
13(1)
1.4.6 Lifestyle
14(1)
1.4.7 Alcohol
15(1)
1.4.8 Tobacco
15(1)
1.4.9 Overweight and obesity
15(1)
1.5 Cancer and obesity
16(1)
1.6 Cancer factors according to affected body site
17(16)
1.6.1 Head and neck cancer
17(1)
1.6.2 Respiratory system cancer
17(2)
1.6.3 Digestive system cancer
19(6)
1.6.4 Urinary system cancer
25(2)
1.6.5 Reproductive system cancer
27(2)
1.6.6 Central nervous system cancer
29(1)
1.6.7 Hematological neoplasia
30(2)
1.6.8 Challenges and policies
32(1)
1.7 Conclusions
33(1)
Acknowledgments
33(1)
References
33(8)
2 Molecular and therapeutic bases of cancer 41(58)
G.R. Fajardo-Orduna
D. Chamorro-Plata
2.1 Introduction
41(2)
2.1.1 Hallmarks of cancer
42(1)
2.2 Grow promotion and cell death suppression
43(6)
2.2.1 The Interplay of oncogenes and tumor suppression genes
43(5)
2.2.2 Posttranslational modifications
48(1)
2.3 Cell signaling
49(1)
2.3.1 Ras protein
49(1)
2.3.2 Receptors
49(1)
2.4 Replicative immortality and telomere dysfunctions
50(1)
2.5 Mechanisms of cell death: cell cycle checkpoints and DNA damage response
51(1)
2.5.1 Cell cycle checkpoints
51(1)
2.5.2 Cell death suppression
52(1)
2.6 Invasion and metastases
52(7)
2.6.1 Molecular drivers of metastasis
53(1)
2.6.2 Angiogenesis
54(4)
2.6.3 Immune evasion
58(1)
2.7 Metabolic reprograming in cancer
59(5)
2.7.1 Mechanisms of cancer metabolic reprograming
60(1)
2.7.2 Oncogenes and tumor suppressor genes in metabolism reprograming
60(1)
2.7.3 Cell signalling pathways in metabolism reprograming
61(1)
2.7.4 Cancer-producing factors in metabolism reprograming
61(1)
2.7.5 Reactive oxygen species in metabolism reprograming
61(1)
2.7.6 Metabolic plasticity of cancer: metabolic heterogeneity in cancer cells and stroma
62(1)
2.7.7 Cancer stem cells metabolism
63(1)
2.7.8 Metabolic reprograming in metastasis
63(1)
2.8 Microenvironment
64(2)
2.9 Inflammation
66(2)
2.9.1 Obesity and hyperinsulinemia
67(1)
2.10 Epigenetic of cancer
68(2)
2.10.1 Epigenetic mechanisms
68(1)
2.10.2 Epigenetic in cancer
69(1)
2.10.3 Inducers of epigenetic alterations
69(1)
2.10.4 Epigenetic heterogeneity in cancer
70(1)
2.10.5 Epigenetic and metabolism interplay in cancer
70(1)
2.11 Cancer and the circadian clock
70(1)
2.12 Treatment
71(11)
2.12.1 Precision medicine
71(2)
2.12.2 Stem cell transplant
73(1)
2.12.3 Immunotherapy
74(1)
2.12.4 Conventional treatment
75(2)
2.12.5 Palliative care
77(1)
2.12.6 New treatments
77(5)
2.13 New paradigms of old ideas
82(1)
2.13.1 A social perspective of cancer
83(1)
2.14 Conclusions
83(1)
Acknowledgments
84(1)
References
84(15)
3 Macronutrients and micronutrients in cancer prevention and treatment 99(26)
A.M. Martin Ortega
M.R. Segura Campos
3.1 Introduction
99(1)
3.2 Macronutrients in cancer
99(9)
3.2.1 Protein
100(1)
3.2.2 Carbohydrates
101(3)
3.2.3 Lipids
104(4)
3.3 Micronutrients
108(10)
3.3.1 Vitamin A
109(1)
3.3.2 Vitamin B1 (thiamine)
109(1)
3.3.3 Vitamin B9 (folate and folic acid)
110(1)
3.3.4 Vitamin B12 (cyanocobalamin)
111(1)
3.3.5 Vitamin C (ascorbic acid)
112(1)
3.3.6 Vitamin D
113(1)
3.3.7 Vitamin E
114(1)
3.3.8 Zinc
115(1)
3.3.9 Magnesium
116(1)
3.3.10 Selenium
117(1)
3.4 Conclusions
118(1)
References
118(7)
4 Phytochemicals in cancer treatment 125(36)
A.M. Martin Ortega
M.R. Segura Campos
4.1 Introduction
125(1)
4.2 Phytochemicals
126(26)
4.2.1 Curcumin
126(1)
4.2.2 Resveratrol
127(3)
4.2.3 Indole-3-carbinol
130(2)
4.2.4 Lycopene
132(2)
4.2.5 Sulforaphane
134(2)
4.2.6 Beta-carotene
136(2)
4.2.7 Allicin
138(2)
4.2.8 Lutein
140(2)
4.2.9 Anthocyanins
142(2)
4.2.10 Epigallocatechin-3-gallate
144(2)
4.2.11 Gingerol
146(2)
4.2.12 Quercetin
148(2)
4.2.13 Genistein
150(2)
4.3 Conclusions
152(1)
References
153(8)
5 Medicinal plants as potential functional foods or resources for obtaining anticancer activity metabolites 161(34)
L.A. Victoria Monroy
J.R. Caamala Cauich
A.M. Martin Ortega
M.R. Segura Campos
5.1 Introduction
161(1)
5.2 Medicinal plants with anticancer potential
162(27)
5.2.1 Aloe (Aloe vera)
162(1)
5.2.2 Cancerina (Semialarium mexicanum (Miers) Mennenga or Hippocratea excelsa)
163(2)
5.2.3 Kalanchoe genus: Kalanchoe flammea, Kalanchoe tubiflora, Kalanchoe daigremontiana, and Kalanchoe pinnata
165(1)
5.2.4 Moringa (Moringa oleifera)
166(2)
5.2.5 Neem (Azadirachta indica)
168(2)
5.2.6 Ganoderma (Ganoderma lucidum)
170(1)
5.2.7 Amla (Emblica officinalis)
171(2)
5.2.8 Quince (Cydonia oblonga)
173(2)
5.2.9 Noni (Morinda citrifolia)
175(1)
5.2.10 Cuachalalate (Amphipterygium adstringens)
176(1)
5.2.11 Cow's tongue (Sansevieria roxburghiana)
177(2)
5.2.12 Muicle (Justicia spicigera)
179(1)
5.2.13 Cat's claw (Uncaria tomentosa)
180(1)
5.2.14 Pink lapacho (Tabebuia avellanedae)
181(2)
5.2.15 Chamomile (Matricaria chamomilla)
183(2)
5.2.16 African cabbage, spider tuft, or cat's whiskers (Cleome gynandra)
185(2)
5.2.17 The devil's staff (Oplopanax horridus)
187(1)
5.2.18 Hedgehog (Sisymbrium officinale)
188(1)
5.3 Conclusions
189(1)
Acknowledgments
189(1)
References
190(5)
Index 195
Maira Rubi Segura Campos is the lead research professor at the Faculty of Chemistry Engineering and the coordinator of the Institutional Postgraduate in Chemical and Biochemical Sciences at the Autonomous University of Yucatan, Mérida, Mexico. She has authored 115 articles in national and international journals, 61 book chapters, 12 books, and 41 memoirs. She has also taught more than 170 courses at the pre-and postgraduate level and has actively participated in 170 national and international academic events. Armando Manuel Martķn Ortega is a nutriologist at the Autonomous University of Yucatan (UADY), Mérida, Mexico. He is research assistant to Dr. Maira Rubi Segura Campos in Faculty of Chemical Engineering at UADY. He has contributed to multiple research projects and has co-authored a variety national and international articles as well as book chapters.
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