| Contributors |
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xiii | |
| Preface |
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xvii | |
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1 Evolution of proopiomelanocortin |
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1 | (16) |
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Jose Miguel Cerda-Reverter |
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1 | (1) |
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2 Evolution of opioid peptides and nociceptin/orphanin family |
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2 | (8) |
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10 | (3) |
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13 | (1) |
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13 | (1) |
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13 | (4) |
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2 Structure and dynamics of dynorphin peptide and its receptor |
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17 | (32) |
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1 Dynorphin: A neuropeptide involved in pain, addiction and mood regulation |
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18 | (4) |
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2 The molecular mechanism of action of dynorphin: Research and hypotheses prior to KOP cloning |
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22 | (2) |
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3 KOP cloning, site-directed mutagenesis and heterologous expression systems |
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24 | (2) |
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4 Structure and dynamics of dynorphin and its receptor based on experimental 3D structures |
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26 | (4) |
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5 Building 3D models of dynorphin-KOP complexes |
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30 | (3) |
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6 Development of novel KOP ligands based on structural knowledge |
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33 | (1) |
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7 Conclusions and future perspectives |
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34 | (1) |
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35 | (14) |
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3 Molecular aspects of delta opioid receptors |
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49 | (42) |
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1 The delta opioid receptor (DOP) |
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50 | (1) |
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2 Advances in the resolution of GPCR structures |
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51 | (10) |
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3 Trafficking of DOP to the plasma membrane |
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61 | (5) |
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4 Molecular mechanisms of DOP signaling |
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66 | (4) |
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5 Molecular mechanisms underlying regulation of DOP signaling |
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70 | (6) |
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76 | (1) |
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76 | (1) |
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76 | (15) |
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4 The role of heat shock protein 90 in regulating pain, opioid signaling, and opioid antinociception |
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91 | (14) |
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92 | (1) |
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93 | (2) |
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3 Hsp90 in opioid signaling and antinociception |
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95 | (3) |
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98 | (1) |
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99 | (1) |
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99 | (6) |
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5 Enkephalinase regulation |
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105 | (26) |
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Magdalena Martinez-Canamero |
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1 Enkephalins and enkephalinases |
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106 | (2) |
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2 Brain distribution and development (regional and subcellular) |
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108 | (4) |
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112 | (3) |
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115 | (3) |
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118 | (1) |
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119 | (2) |
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7 Neurotransmitters interactions |
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121 | (3) |
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8 Conclusions and future directions |
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124 | (1) |
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124 | (1) |
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124 | (7) |
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6 Limbic circuit connectivity and the stress response: New insights into the mammalian nociceptin peptide system |
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131 | (16) |
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1 Mechanisms underlying the stress modulatory effects of the neuropeptide nociceptin |
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132 | (2) |
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2 Neuropharmacological basis of nociceptin effects in stress and anxiety |
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134 | (2) |
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3 Stress and the thalamic reticular nucleus |
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136 | (3) |
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4 Nociceptin and neurodevelopmental disorders |
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139 | (1) |
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140 | (1) |
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141 | (4) |
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145 | (2) |
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7 Enkephalins and ACTH in the mammalian nervous system |
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147 | (48) |
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148 | (1) |
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148 | (2) |
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3 Structure of the enkephalin/ACTH genes |
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150 | (1) |
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4 Processing of the precursors |
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151 | (3) |
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154 | (4) |
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6 Receptors and signaling cascades |
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158 | (4) |
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162 | (7) |
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169 | (12) |
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9 Conclusion and future perspectives |
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181 | (1) |
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181 | (1) |
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182 | (13) |
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8 Opioids and the hormone oxytocin |
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195 | (32) |
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196 | (1) |
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2 Effects of endogenous and exogenously administered opioids on brain OT systems |
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197 | (8) |
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3 Effects of endogenous and exogenously administered oxytocin on opioid use disorders |
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205 | (4) |
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209 | (6) |
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215 | (1) |
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216 | (9) |
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225 | (2) |
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9 Estrogens as arbiters of sex-specific and reproductive cycle-dependent opioid analgesic mechanisms |
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227 | |
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228 | (2) |
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2 Sexually dimorphic opioid mechanisms mediate comparable opioid analgesia |
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230 | (1) |
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3 Influence of estrogens on the physical relationship of MOR and KOR |
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231 | (1) |
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4 Estrogens can influence the balance between antinociception and pronociception induced by dynorphin-KOR signaling |
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232 | (1) |
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5 Spinal ER-mGluRl signaling suppresses EM2 analgesia |
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233 | (1) |
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6 Estrogenic signaling suppresses endogenous spinal EM2 release |
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234 | (1) |
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7 Estrogenic signaling enables coordination of spinal EM2 utilization with physiological demand |
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235 | (1) |
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8 Collaboration between spinally- and ovarian-produced estrogens |
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235 | (1) |
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9 Multiple subpopulations of CNS aromatase and mERα |
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236 | (3) |
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239 | (1) |
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239 | (1) |
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239 | (8) |
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10 Opioids and reproduction |
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247 | (1) |
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248 | (1) |
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2 Effects of opioids in the central nervous system on the reproductive system |
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249 | (6) |
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3 Peripheral action of the opioid system |
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255 | (6) |
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4 Pathophysiology of the opioid system in reproductive disorders |
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261 | (4) |
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265 | (5) |
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270 | (1) |
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271 | (10) |
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11 Kappa opioid receptor and oligodendrocyte remyelination |
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281 | (1) |
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1 Oligodendrocyte and remyelination |
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282 | (3) |
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2 Opioids in regulating oligodendroglial differentiation |
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285 | (4) |
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3 Endogenous opioid signaling in oligodendroglia |
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289 | (2) |
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291 | (1) |
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291 | (8) |
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12 Inhibitory role of Gi-coupled receptors on cAMP-driven cancers with focus on opioid receptors in lung adenocarcinoma and its stem cells |
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299 | (1) |
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300 | (1) |
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2 Antagonistic effects of Gs- and Gi-coupled receptors on pulmonary adenocarcinoma and its stem cells |
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301 | (4) |
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3 Anti-carcinogenic effects of methadone |
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305 | (1) |
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4 Anti-carcinogenic effects of cannabinoids |
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305 | (1) |
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306 | (1) |
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307 | (6) |
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13 Prenatal ethanol exposure and enkephalinergic neurotransmission |
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313 | (1) |
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314 | (2) |
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2 Alcohol reinforcement: Activation of dopaminergic mesocorticolimbic transmission |
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316 | (1) |
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3 Role of opioid peptides in alcohol reinforcement |
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317 | (1) |
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4 Alcohol effects on enkephalinergic and β-endorphinergic transmission |
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318 | (13) |
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331 | (1) |
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331 | |
Biežāk uzdotie jautājumi par e-grāmatām