Contributed by sleep medicine, neuroscience, psychiatry, and other specialists from North America, Japan, Israel, and Europe, the 12 articles in this book explore the basic science and role of the orexin system in sleep pathology. They discuss its role in regulating sleep and wakefulness, including its interaction with other sleep and wake-regulating neurotransmitter systems, its role in different sleep phases, and its relationship to memory and cognition; the cellular and molecular aspects of the system, including the subsecond ensemble dynamics of orexin neurons that link sensation and action, the heterogeneity of hypocretin/orexin neurons, the implications of lateral hypothalamic neurons for sleep and metabolism, and cellular signaling mechanisms of hypocretin/orexin; and diseases caused by or associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, chronic sleep deficiency, and Alzheimer's disease. Annotation ©2021 Ringgold, Inc., Portland, OR (protoview.com)
The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep and wake, and its interaction with other wake-regulating systems. The orexin system is dissected at the cellular and molecular level to explore the diversity of the orexin-producing neurons, their projections, and their signaling pathways. Additionally, the book discusses the diseases which are associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, and Alzheimers disease, and explores the new potential therapeutic applications derived from the burst of research around this fascinating system. This publication is essential reading for neurobiologists, neurologists, psychopharmacologists, sleep researchers, and other researchers and clinical scientists interested in sleep, sleep research, insomnia, and medicine in general.
