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E-grāmata: Osteoporosis Primer

Edited by (McGill University, Montréal), Edited by (McGill University, Montréal)
  • Formāts: PDF+DRM
  • Izdošanas datums: 24-Aug-2000
  • Izdevniecība: Cambridge University Press
  • Valoda: eng
  • ISBN-13: 9780511036750
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Osteoporosis PrimerPalielināt
  • Formāts: PDF+DRM
  • Izdošanas datums: 24-Aug-2000
  • Izdevniecība: Cambridge University Press
  • Valoda: eng
  • ISBN-13: 9780511036750
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Osteoporosis is one of the leading causes of morbidity and mortality among the elderly. The rationale for The Osteoporosis Primer is to provide an introductory text that relates the clinical presentation of osteoporosis to its molecular biochemical basis. The text has been organized into four sections that deal with the molecular/cellular components of bone, the development of peak bone mass, the pathophysiology of aging bone and finally, how all of these relate to the prevention, diagnosis, and treatment of osteoporosis. The international team of authors includes many leading clinicians and scientists who have provided the reader with a concise, yet comprehensive, synopsis of bone development and skeletal homeostasis. This book will be an essential introduction for individuals working on osteoporosis, including students and doctors considering a career related to metabolic bone disease, general practitioners, geriatricians, rheumatologists, and endocrinologists.

The Osteoporosis Primer provides an excellent introduction that relates the clinical presentation of osteoporosis to its molecular biochemical basis, and reviews therapeutic options.

Recenzijas

'I really enjoyed tying together the cell biology and the basis of the current treatments and potential therapeutic interventions. I found that I knew a lot more about bone cell physiology, bone turnover and cell signalling by the end of the section. The book succeeds as an introductory text on metabolic bone disease and provides insight into the complexity of the subject without becoming overwhelming.' Gerontology 'A clearly written and updated text on a topic of increasing interest.' Journal of Pediatric Endocrinology and Metabolism 'This is a concise yet comprehensive synopsis of bone developments and skeletal homeostasis.' Aslib Book Guide

Papildus informācija

The Osteoporosis Primer provides an excellent introduction that relates the clinical presentation of osteoporosis to its molecular biochemical basis, and reviews therapeutic options.
List of contributors viii Preface xiii Part 1 Molecular and cellular environment of bone Endochondral bone formation and development in the axial, and appendicular skeleton 3(15) A. Robin Poole Sheila Laverty Fackson Mwale The role of osteoblasts 18(18) Jane E. Aubin Osteoclasts: characteristics and regulation of formation and activity 36(10) Johan N. M. Heersche Morris F. Manolson Bone matrix proteins 46(18) Marc D. McKee Jaro Sodek Local regulators of bone turnover 64(9) Lawrence J. Fraher Patricia H. Watson The PTH/PTHrP system and calcium homeostasis 73(15) Geoffrey N. Hendy Vitamin D metabolism 88(14) Marielle Gascon-Barre Sodium-dependent phosphate transport in kidney, bone and intestine 102(12) Harriet S. Tenenhouse Molecular genetic analysis of growth factor signaling in bone 114(17) Janet E. Henderson David Goltzman Part 2 Determinants of peak bone mass Genetic determinants of osteoporosis 131(16) Millan S. Patel Laurence A. Rubin David E. C. Cole Non-genetic determinants of peak bone mass 147(23) Velimir Matkovic John D. Landoll Bone mineral acquisition during childhood and adolescence: physical exercise as a preventative measure 170(16) Heather A. McKay Karim M. Khan Osteoporosis in children 186(13) Frank Rauch Francis H. Glorieux Part 3 Pathophysiology of the aging skeleton Consequences of alterations in bone remodeling 199(12) Karen M. Prestwood Lawrence G. Raisz The role of parathyroid hormone and hyperparathyroidism in osteoporosis 211(14) Pierre DAmour Senile osteoporosis 225(14) Patrick M. Doran Sundeep Khosla Part 4 Clinical aspects of osteoporosis Biochemical markers of bone turnover 239(14) David A. Hanley Radiologic assessment of osteoporosis 253(9) Jacqueline C. Hodge Bone mineral density measurements 262(15) Paul D. Miller Carol Zapalowski Hormone replacement therapy 277(14) Jonathan D. Adachi Alexandra Papaioannou Selective estrogen receptor modulators 291(13) Felicia Cosman Robert Lindsay Bisphosphonate therapy of osteoporosis 304(14) Frederick R. Singer Payam Minoofar The action of fluoride on bone 318(13) Marc D. Grynpas Debbie Chachra Hardy Limeback PTH peptides as anabolic agents in bone 331(16) Anthony B. Hodsman Vitamin D and vitamin D analogs as therapeutic agents 347(17) Richard Kremer Index 364
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