This book is a thorough, practical review of the challenges facing clinicians treating skin microbes and how to combat these therapeutic dilemmas. It expresses the critical public health concern of antimicrobial resistance and shows how microorganisms are developing the ability to halt the progress of antimicrobials like antibiotics, antivirals, and antifungals.
Chapters are grouped together in five sections for ease of use. The first three sections of the book convey foundational information on the mechanisms of antibiotics, antivirals, and antifungals resistance, as well as the implications of lack of vaccination. The fourth section then turns to the specifics of drug resistance for protozoan and helminth infections focusing primarily on initial and subsequent resistance to treatment. The book closes with a discussion on the potential solutions of innovative therapy including new delivery mechanisms, broad-spectrum antibiotics, phytocompounds, and biofilms. Chapters feature magnified, microscopic photos for identifying structures as they appear on the skin.
Part of the Updates in Clinical Dermatology series, Overcoming Antimicrobial Resistance of the Skin is an important resource relevant during the COVID-19 pandemic, and is written for all medical healthcare professionals.
Section I: Emerging Bacterial Resistance to Antibiotics.- Ch 1:
Mechanisms of Bacterial Resistance.- Ch 2: Emerging Bacterial Infections.- Ch
3: Re-Emerging Bacterial Infections of the Skin.- Section II: Emerging
Resistance to Antivirals.- Ch 4: Mechanisms of Nonretroviral Resistance.- Ch
5: Mechanisms of Retroviral Resistance.- Ch 6: Emerging Viral Infections.- Ch
7: Re-Emerging Viral Infections - Implications of Lack of Vaccination.-
Section III: Emerging Resistance to Antifungals.- Ch 8: Mechanisms of
Antifungal Resistance.- Ch 9: Emerging and Re-Emerging Fungal Infections.-
Section IV: Emerging Resistance to Drugs for Protozoan and Helminth
Infections.- Ch 10: Mechanisms of Anti-Protozoan/Helminth Drug Resistance.-
Ch 11: Emerging and Re-Emerging Protozoan/Helminth Infections.- Section V:
Innovative Therapies on the Forefront.- Ch 12: Phage Therapy.- Ch 13: The
Role of Biofilms and the Microbiome.- Ch 14: New Classes of Broad-Spectrum
Antibioticsand New Mechanisms of Delivery.- Ch 15: Phytocompounds.- Ch 16:
Summary: Overcoming Antimicrobial Resistance of the Skin.
Stephen K. Tyring, MD, PhDUniversity of Texas Health Science CenterCenter for Clinical StudiesHouston, TXUSA Stephen Andrew MooreArlington Center for DermatologyArlington Research CenterArlington, TXUSA Angela Yen Moore, MDArlington Center for DermatologyArlington Research CenterArlington, TXUSA Omar Lupi, MD, MSc, PhDUniversidade Federal do Estado do Rio de Janeiro (UNIRIO)Policlinica Geral do Rio de Janeiro (PGRJ)Ibero Latin American College of Dermatology (CILAD) International League of Dermatological Societies (ILDS)Brazil
