The author examines individual susceptibility to dental caries, erosive tooth wear, and disturbances of dental development, focusing on genetic aspects. He discusses the basis of inheritance in humans in the context of dental caries, erosive tooth wear, and amelogenesis; genetic mutation that causes amelogenesis imperfecta; the genetic component of dental caries, as well as dietary interventions; animal models on the genetics of dental caries; twin studies on their heritability; wine tasters and erosive tooth wear; the genes involved in enamel formation and saliva formation and composition and their impact on caries susceptibility and erosive tooth wear; the impact of dietary preferences; genes interacting with fluorides, influencing behavior, and involved in immune response and their impacts; the initiation of caries and erosive tooth wear and lesions, their progression, and adhesive restorative dental treatment; genomic predictors of caries experience and erosive tooth wear; and fluoride and its benefits and toxicity. Annotation ©2022 Ringgold, Inc., Portland, OR (protoview.com)
Individual susceptibility to disease (i.e., ones own genetic background) is one of the three main components classically described in the etiology of dental caries. Hence, genes influence susceptibility to erosive tooth wear, dental development, and response to treatments and interventions. This publication is an up-to-date overview of individual susceptibility to dental caries, erosive tooth wear, and disturbances of dental development from different clinically relevant perspectives. One of the most recognized scientists in this field reports on recent research relating to human genetics from general summaries to recommendations for daily clinical work and population-level interventions. This book covers all aspects of individual susceptibility to dental caries and erosive tooth wear. Several chapters deal with potential biological mechanisms, with additional ones providing a strong foundation in human genetics, and other chapters touch on efficacy of therapies and alternative concepts. This book is particularly recommended to dental medicine students, practitioners, other oral healthcare professionals, and scientists with an interest in translational research on dental caries and erosive tooth wear.
