This book provides up-to-date insights into the COVID-19 disease, addressing its outbreak, pathogenesis, biology, treatment interventions, and consequences as a global health crisis. Divided into six sections, the book covers a detailed examination of various facets of the disease. Section I delves into the host"s genetic and epigenetic mechanisms in response to COVID-19. Section II focuses on disease diagnosis, providing valuable perspectives on kits, nucleic acid testing, immunological assays, imaging-based diagnosis, and variant-specific SARS-COV-2 detection. Section III covers cytokine storm, inflammation, and immunity, including the modulation of signaling pathways leading to immune evasion and persistence. Section IV reveals drug repurposing, exploring antiviral, anti-inflammatory, anti-platelet drugs, and target-based drug discovery. Section V explains the evolution of vaccine development including DNA, RNA, subunit, and viral vaccines. Finally, Section VI explores COVI
D-19"s impact on associated comorbidities, ranging from cancer and cardiac issues to neurological damages and economic consequences.The book is relevant for scientists, and researchers working on pathogenesis, development, implementation, host-pathogen interactions, and drug repurposing of COVID-19 disease.
Part 1 COVID-19 Pandemic: Pathogenesis, Inflammation, and Biology.- Ch 1 The COVID-19 Outbreak.- Ch 2 Pathogenesis and Biology of SARS-CoV-2.- Ch 3 COVID-19: Modulation of Host s Genetic and Epigenetic Machineries.- Ch 4 SARS-CoV-2 Mutants and Variants of Interest.- Part 2 COVID-19: Diagnosis and Development of Diagnostics.- Ch 5 Imaging-Based COVID-19 Diagnosis.- Ch 6 Nucleic Acid Amplification Testing (NAAT) based COVID-19 Kits.- Ch 7 Immunological Assay Based COVID-19 Detection.- Ch 8 Variant-Specific Diagnosis of COVID-19.- Part 3 COVID-19: Immunological Perspectives.- Ch 9 Cytokine Storm, Inflammation, and Immunity in COVID-19.- Ch 10 COVID-19: Modulation of Signaling Pathways.- Ch 11 Immunological Persistence and Risk of SARS-CoV-2 Re-infection: Insights and Implications.- Ch 12 Plasma Therapy in COVID-19.- Part 4 COVID-19 Drug Repurposing: Mode of Action, Clinical Trials, and Future Perspectives.- Ch 13 Repurposing of Anti-viral Agents in COVID-19.- Ch 14 Role of Anti-i
nflammatory Agents in the Management of COVID-19.- Ch 15 Application of Anti-platelet Drugs and Anti-coagulants in COVID-19.- Ch 16 COVID-19: Target-Based Drug Discovery.- Part 5 COVID-19: Vaccine Development and Vaccination.- Ch 17 COVID-19: Vaccine Classification and their Clinical Status.- Ch 18 SARS-CoV-2: A Comprehensive Insight into DNA, RNA, Subunit, and Viral Vaccines.- Ch 19 COVID-19 Vaccination in Medically Distinct Population.- Part 6 COVID-19 Associated Comorbidities, Economic and Societal Impact.- Ch 20 Neurological damages in COVID-19 patients.- Ch 21 COVID-19 Comorbidities in Cancer.- Ch 22 Interplay of COVID-19 with Tuberculosis and Pneumonia: Challenges and Treatment.- Ch 23 Economic Consequences of the COVID-19 Pandemic.- Ch 24 COVID-19 Pandemic and Its Societal Impact: A Philosophical/Theoretical Perspective in Human Quantum Mechanics.- Ch 25 Unravelling the Global Economic Impact: A Region and Sector-wise Post-COVID Analysis.- Ch 26 Navigating Long COVID: Como
rbidities and the Global Societal Impact.
