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Perioperative Neuroscience: Translational Research [Mīkstie vāki]

Edited by (Department of Neuroanaesthesiology and Critical Care, Neurosciences Center, AIIMS, New Delhi, India), Edited by (Department of Neuroanaesthes), Edited by (Department of Neuroanaesthesiology and Critical Care, Neurosciences Center, AIIMS, New Delhi, India)
  • Formāts: Paperback / softback, 260 pages, height x width: 229x152 mm, weight: 430 g
  • Izdošanas datums: 01-Mar-2022
  • Izdevniecība: Academic Press Inc
  • ISBN-10: 0323910033
  • ISBN-13: 9780323910033
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Perioperative Neuroscience: Translational ResearchPalielināt
  • Formāts: Paperback / softback, 260 pages, height x width: 229x152 mm, weight: 430 g
  • Izdošanas datums: 01-Mar-2022
  • Izdevniecība: Academic Press Inc
  • ISBN-10: 0323910033
  • ISBN-13: 9780323910033
Citas grāmatas par šo tēmu:
Permanent link: https://www.kriso.lv/db/9780323910033.html
Keywords:

Perioperative Neurosciences: Translational Research examines current clinical research focused on complications and the improvement of patient outcomes in neuroanesthesia and neurocritical care. The book addresses important translational topics including neuroanesthetics, pharmacogenomics, neuroprotection and neurotoxicity. In addition, it covers special considerations for topics such as stroke, traumatic brain injury and pain, as well as for specific patient populations like geriatric and pediatric.

  • Addresses translational developments in pharmacogemonics, brain protection and neurotoxicity
  • Discusses ethical concerns relevant to clinical research in perioperative neuroscience
  • Collates insights from international experts in translating research to practice
List of Contributors
xiii
Foreword xvii
Acknowledgment xix
1 Introduction
1(6)
Indu Kapoor
Cham Mahajan
Hemanshu Prabhakar
Translational research and neurosciences
1(2)
References
3(4)
2 Basic principles of translational research
7(18)
Yusuke Naito
Masahiko Kawaguchi
Introduction to translational research
7(1)
What is translational research?
7(2)
History of translational research
9(2)
Current concepts and domains
11(3)
Ethics and regulations
14(3)
Ethical issues in T1: embryonic stem cells and induced pluripotent stem cells
17(1)
Ethical issues in T2: artificial red blood cell products
17(1)
Ethical issues in T3--4: the thalidomide drug incident
18(1)
Education and careers
19(1)
Conclusions
20(1)
References
21(4)
3 Anesthetics and translational research
25(16)
Marco Cascella
Introduction
25(1)
Induction and emergence from anesthesia processes
26(1)
Overview on mechanisms
26(2)
Applicability clinical practice
28(1)
Anesthetics and consciousness: the "awareness" paradox
29(2)
General anesthetics and neurodegenerative processes
31(2)
Impact on carcinogenic processes
33(1)
Perspectives
34(1)
Conclusion
35(1)
References
35(6)
4 Neurotoxicity and translational research
41(18)
Zachary Fleissner
Antonia Schonwald
Neil Patel
Benjamin F. Gruenbaum
Valerie A. Smart
Shaun E. Gruenbaum
Introduction
41(1)
Preclinical evidence and the use of animal models
42(1)
Volatile anesthetics
42(1)
Ketamine
43(1)
Propofol
44(1)
Anesthesia and neurotoxicity: mechanisms
44(2)
From laboratory to clinical trials: evidence in humans
46(2)
Exposure to anesthesia and the elderly
48(1)
Neuroprotective strategies in the perioperative setting
49(1)
Dexmedetomidine
50(1)
Rutin
50(1)
Vitamin C
50(1)
Modulation of TNF-alpha expression
51(1)
Lithium
51(1)
Anesthesia and neurotoxicity: future experimental modalities
52(1)
Neuroimaging
52(1)
Translational biomarkers of neurotoxicity
52(1)
Conclusions
52(1)
References
53(6)
5 Neuromonitoring and translational research
59(22)
Ankur Luthra
Summit Bloria
Rajeev Chauhan
Sameer Sethi
Introduction
59(1)
Clinical monitoring
59(1)
Glasgow coma score
59(1)
Combined GCS-pupils score
60(1)
Full Outline of Unresponsiveness score
60(1)
For aneurysmal subarachnoid hemorrhage patients
60(3)
For ischemic stroke patients
63(1)
Imaging studies
64(1)
Noncontrast computerized tomography
64(2)
Perfusion computerized tomography
66(1)
Intracranial pressure and derived indices
67(1)
External ventricular catheters
67(1)
Parenchymal microtransducer devices
67(1)
Camino transducers
67(1)
Codman microsensor
67(1)
Spiegelberg ICP monitor
68(1)
Optic nerve sheath diameter
68(1)
Transcranial Doppler
69(1)
Pupillometry
69(1)
Thermal diffusion flowmetry
70(1)
Jugular venous oxygen saturation
71(1)
Brain tissue oxygen partial pressure
72(1)
Near infrared spectroscopy
73(1)
Brain metabolism and biochemistry
73(2)
Electroencephalography
75(1)
Evoked potentials
75(1)
Conclusion
76(1)
References
76(5)
6 Cognition and translational research
81(14)
Francesca Rubulotta
Ahmed Ezzat
Zena Radi
Federico Billotta
Introduction
81(1)
Cognitive dysfunctions in the perioperative period: definition and diagnosis
81(2)
Animal models of cognitive dysfunction in perioperative neuroscience
83(2)
Anesthetics
85(2)
Clinical studies investigating cognitive dysfunction in perioperative neuroscience
87(1)
Hospitalization
87(1)
Surgery including bleeding requiring blood transfusions
87(2)
Perioperative care for patients with known presurgery cognition dysfunctions
89(1)
Limits of translational research for inconsistencies of evidence from preclinical studies
89(1)
Conclusion
89(1)
References
90(5)
7 Geriatrics and translational research
95(16)
Suparna Bharadwaj
Sangeetha R. Palaniswamy
Cellular, biochemical, and molecular biology of aging
95(1)
Chromosome and telomere regulation
96(1)
Transcription regulation
96(1)
Nuclear trafficking and organization
96(1)
Protein translation
96(1)
Proteostasis
96(1)
Unfolded protein response
96(1)
Autophagy
97(1)
Mitochondrial function, biogenesis, and mitophagy
97(1)
Cytoskeletal integrity
97(1)
Replicative aging senescence and renewal
97(1)
Physiology, immunology, and endocrinology of aging
97(1)
Physiological changes: changes in nervous system
97(2)
Mechanisms and intervention of cellular senescence and stem cell aging
99(1)
Computational and functional genomics of aging
99(1)
Animal models of aging research
99(3)
Geroprotectors as antiaging chemicals
102(1)
Primary criteria for potential geroprotectors
102(1)
Secondary criteria for potential geroprotectors
102(1)
Classification of geroprotectors
102(3)
Human experiments on longevity
105(1)
Utility of epigenetic clock in aging and age-related diseases
106(1)
Conclusion
107(1)
References
107(4)
8 Pediatrics and translational research
111(10)
Kulikov Alexander
Russi Mariarita
Bilotta Federico
Introduction
111(1)
Preclinical research on perioperative anesthetics neurotoxicity
111(3)
Clinical research on perioperative anesthetics neurotoxicity in children
114(2)
Reasons for discrepancy between preclinical and clinical data
116(1)
Conclusion
117(1)
References
118(3)
9 Stroke and translational research
121(18)
Chandril Chugh
Animal models for ischemic stroke
122(1)
Model for stroke risk factors
123(1)
Hyperglycemia and obesity
123(3)
Neuronal protection
126(1)
Free radical scavengers
126(1)
Delayed neuronal injury
127(1)
Inflammation
127(1)
Regeneration in stroke and neuronal repair
128(1)
Growth promoters
129(1)
Other drugs
130(1)
Conclusion
130(1)
References
130(9)
10 Traumatic brain injury and translational research: pharmacological and nonpharmacological perspectives
139(16)
Denise Battaglini
Chiara Robba
Paolo Pelosi
Introduction
139(1)
Pathophysiology of traumatic brain injury
139(2)
The question/controversy
141(1)
Pharmacological interventions in traumatic brain injury
141(4)
Nonpharmacological interventions in traumatic brain injury
145(3)
Consensus statement
148(1)
Conclusion
148(1)
Conflict of interest
148(1)
Authors' contribution
148(1)
References
148(7)
11 Movement disorders and translational research
155(24)
Supriyo Choudhury
Sakhi Bhansali
Mona Tiwari
Hrishikesh Kumar
Etiology, diagnosis, and monitoring
155(1)
Biomarkers
155(9)
In prevention and treatment
164(8)
Conclusion
172(1)
References
172(7)
12 Epilepsy and translational research
179(10)
Mariangela Panebianco
Introduction
179(1)
Diagnostic evaluation
180(1)
History and neurologic examination
180(1)
Neurophysiological examinations
180(1)
Neuroimaging techniques
180(1)
Other neuroimaging techniques
181(1)
Metabolic evaluation
181(1)
Genetic testing
181(1)
Treatment
182(1)
Future perspective of translational research
183(3)
References
186(3)
13 Translational research in delayed cerebral ischemia
189(14)
Vanitha Rajagopalan
Vasudha Singhal
Cham Mahajan
Introduction
189(1)
Experimental aneurysmal subarachnoid hemorrhage
189(1)
Characteristics of experimental SAH models
190(1)
Perspectives on the current status of SAH animal models
190(2)
Failure in current SAH studies
192(1)
Delayed brain injury
193(1)
Delayed cerebral vasospasm: from extravascular blood to vessel lumen
193(1)
Microcirculatory spasm and dysfunction
194(1)
Microthrombosis: an additional explanation for DCI
195(1)
Cortical spreading ischemia
196(1)
Are we close to solving the mystery of SAH?
196(1)
Future directions
197(1)
Conclusion
197(1)
References
197(6)
14 Translation research in pain medicine
203(12)
Ryan R. Budwany
Yeshvant A. Navalgund
Alaa Abd-Elsayed
Translational research
203(1)
Types of pain
204(1)
Neuropathic pain
204(1)
Nociceptive pain
205(1)
Models in pain management
205(1)
Medical management
205(1)
Interventional management
205(1)
Integrative management
206(1)
Current trends in care
207(1)
Immense opportunity for translational research in pain medicine
208(1)
Bridging the gap between pain research and clinical pain management
208(2)
Analyzing current theories of pain mechanisms and their relevance to clinical pain
210(1)
Exploring new tools for both preclinical and clinical pain research
210(1)
References
211(4)
15 Ethical considerations in translational research
215(10)
Nidhi Gupta
Introduction
215(1)
Evolution of translational research ethics
215(1)
Nuremberg Code (1947)
216(1)
Declaration of Helsinki (1964)
216(1)
Beecher's studies (1966)
216(1)
The Belmont Report (1979)
217(1)
Common Rule (1991)
217(1)
International ethical guidelines
217(1)
Ethical considerations in translational research
218(1)
High-quality preclinical research
218(1)
Informed consent
219(1)
Therapeutic misconception
220(1)
Clinical "equipoise"
220(1)
Incentive payments
221(1)
Review by ethical boards
221(1)
International collaboration
222(1)
Commercialization of translational research
222(1)
Ethical issues in vulnerable neurological population
222(3)
Summary 225(1)
References 225(4)
Index 229
Dr. Hemanshu Prabhakar, MD, PhD, FSNCC, is a Professor at the Department of Neuroanaesthesiology and Critical Care at the All India Institute of Medical Sciences (AIIMS), New Delhi, India. He is a recipient of the AIIMS Excellence Award 2012 for his notable contribution to academia and has published over 350 papers in peer-reviewed national and international journals. Dr. Prabhakar is a Reviewer for various national and international journals and is also a Review Author for the Cochrane Collaboration. He has a special interest in the evidence-based practice of neuroanesthesia and ERAS. Dr. Prabhakar is a Member of various national and international neuroanesthesia societies and is the Past Secretary of the Indian Society of Neuroanesthesia and Critical Care (ISNACC) and the Society of Neurocritical Care (SNCC). He is also the Immediate Past President of the SNCC. To date, he has published more than 25 books on neuroanesthesia and neurocritical care. He is featured in the Limca Book of Records as a prolific Writer in the field of neuroanesthesiology. He actively collaborates on research activities among the low-income and middle-income countries.

Charu Mahajan, MBBS, MD, DM is currently working as an Additional Professor in the Department of Neuroanaesthesiology and Critical Care at All India Institute of Medical Sciences, New Delhi. She has research experience of over a decade backing her profile and has been awarded with the prestigious NBM Gold medal in the subject of surgery in the year 2003. She has more than 50 publications to her name in the form of books and journal alike. She is also the reviewer of various prestigious national journals like the Neurology India and Indian Journal of Anaesthesia and is the member of various scientific bodies such as the SNACC, ISNACC and ISA. Indu Kapoor, MBBS, MD from the prestigious institute Lady Hardinge Medical College [ LHMC] and MD from UCMS Delhi is currently serving as an Additional Professor in the department of Neuroanaesthesiology and Critical Care at All India Institute of Medical Sciences, New Delhi. She has more than 80 research papers published in national and international journals across the globe and numerous chapter contributions in reputed titles. She has also been awarded with the reputed Dr. TN. JHA Memorial Award by the Indian Society of Anaesthesiologists and Smt. Chandra and Sh. Narayan Wadhwani Memorial Award.