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E-grāmata: Pharmaceutical Applications of Dendrimers

Edited by (College of Wisconsin, USA), Edited by (Assistant Professor, Central University of Gujarat, India)
  • Formāts: EPUB+DRM
  • Sērija : Micro & Nano Technologies
  • Izdošanas datums: 15-Nov-2019
  • Izdevniecība: Elsevier Science Publishing Co Inc
  • Valoda: eng
  • ISBN-13: 9780128145289
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Pharmaceutical Applications of DendrimersPalielināt
  • Formāts: EPUB+DRM
  • Sērija : Micro & Nano Technologies
  • Izdošanas datums: 15-Nov-2019
  • Izdevniecība: Elsevier Science Publishing Co Inc
  • Valoda: eng
  • ISBN-13: 9780128145289
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Pharmaceutical Applications of Dendrimers explores the applications of dendrimers in the solubilization of hydrophobic active ingredients, drug delivery, gene delivery, imaging, diagnosis and photodynamic therapy. The book discusses the diagnostic applications of dendrimers, including their use as MRI contrast agents and in the imaging of diseased areas. In addition, the anti-inflammatory, antimicrobial and antiviral properties of PPI and PAMAM are also covered, along with a discussion on photosensitizers, such as rose Bengal and protoporphyrin IX that have been delivered using PAMAM and PPI dendrimers for the treatment of cancer.

This book is an important research reference for those who want to learn more about the development of dendrimer-based solutions for drug delivery.

  • Explores the role of dendrimers in the design of dendritic nanoplatforms for targeted drug and gene delivery systems
  • Discusses the potential of dendrimers in preformulation and formulation development
  • Addresses both clinical and regulatory challenges in the development of dendrimer-based formulations
Contributors xi
Preface xv
SECTION A Dendrimers and their properties
1(56)
1 Engineering critical nanoscale design parameters (CNDPs): A strategy for developing effective nanomedicine therapies and assessing quantitative nanoscale structure-activity relationships (QNSARs)
3(46)
Donald A. Tomalia
Linda S. Nixon
David M. Hedstrand
1 Introduction
3(1)
2 Historical
4(4)
3 Application of nanoperiodic property patterns and CNDP engineering principles to nanomedicine
8(6)
4 Unique dendrimer features that facilitate systematic CNDP engineering for optimized nanomedicine applications
14(1)
5 Nanoparticle structural control and engineering CNDPs: Implications for nanomedicine
15(3)
6 Recent progress in dendrimer based CNDP-engineering
18(5)
7 Optimizing dendrimer properties for nanomedicine applications
23(11)
8 Progress in dendrimer-based CNDP engineering related to quantitative nanostructure-activity relationships (QNSARs) and nanomedicine
34(4)
9 Conclusions
38(1)
Acknowledgment
39(1)
References
39(8)
Further reading
47(2)
2 Dendrimers in drug delivery and the role of "critical nanoscale design parameters" (CNDPs)
49(8)
Abhay Chauhan
1 Introduction
49(1)
2 Dendrimer as drug delivery?
50(2)
3 Critical nanoscale design parameters (CNDPs) in dendrimers for drug delivery
52(4)
References
56(1)
SECTION B Dendrimers for pharmaceutical applications
57(232)
3 Dendrimers for drug solubilization, dissolution and bioavailability
59(34)
Abhay Chauhan
Becka Anton
Mayank K. Singh
1 Introduction
59(1)
2 Molecular features of dendrimers
60(1)
3 Concept of solubility enhancement with dendrimer
61(2)
4 Dendrimer-based solubility enhancement of various classes of drugs
63(16)
5 Dendrimer-based drug-delivery through various routes
79(7)
6 Conclusion
86(1)
Acknowledgments
86(1)
References
86(7)
4 Pharmacokinetic considerations in design of dendrimer-based nanomedicines
93(14)
Lakshmi Tunki
Hitesh Kulhari
Suresh K. Bhargava
Deep Pooja
1 Introduction
93(1)
2 Effect of size, molecular weight, hydrophobicity and charge on pharmacokinetic profile of dendrimers
93(5)
3 Effect of surface functionalization on pharmacokinetic profile of dendrimers
98(5)
4 Conclusion
103(1)
Acknowledgment
104(1)
References
104(3)
5 Dendrimer-based targeted drug delivery
107(24)
Lakshmi Tunki
Hitesh Kulhari
Ramakrishna Sistla
Deep Pooja
1 Introduction
107(1)
2 Designing of dendrimers for drug targeting
107(1)
3 Types of surface modification of dendrimers
108(17)
4 Conclusion
125(1)
References
125(6)
6 Dendrimers for anticancer drug delivery
131(20)
Pushpendra Kumar Tripathi
Shalini Tripathi
1 Introduction
131(1)
2 Brief about dendrimers and application for cancer drug delivery
132(3)
3 PAMAM dendrimer for cancer therapy
135(5)
4 PPI dendrimers for cancer therapy
140(1)
5 PPL dendrimers for cancer therapy
141(3)
6 Conclusion
144(1)
Acknowledgment
144(1)
References
144(7)
7 Cancer-targeted chemotherapy: Emerging role of the folate anchored dendrimer as drug delivery nanocarrier
151(48)
Chitra Rajani
Pooja Borisa
Tukaram Karanwad
Yogeshwari Borade
Vruti Patel
Kuldeep Rajpoot
Rakesh K. Tekade
1 Cancer world "the making of modern disease"
151(16)
2 Nanotechnology
167(8)
3 Dendrimer in nanotechnology
175(17)
4 Conclusion
192(1)
References
192(6)
Further reading
198(1)
8 Design of dendrimer based prodrugs
199(12)
T. Srinivasa Reddy
Suresh K. Bhargava
1 Introduction
199(1)
2 Advantages of dendrimer over other polymers for prodrug preparation
200(1)
3 Advantages of dendrimer prodrugs
201(1)
4 Requirements for dendrimer prodrugs
201(1)
5 Strategies for design and synthesis of dendrimer prodrugs
201(1)
6 Dendrimer prodrugs without spacer
202(3)
7 Dendrimer-prodrugs with spacers
205(1)
8 Conclusion
205(3)
References
208(3)
9 Dendrimers in gene delivery
211(22)
Divya Bharti Rai
Deep Pooja
Hitesh Kulhari
1 Introduction
211(1)
2 Mechanism of gene delivery using dendriplexes
212(3)
3 Factors affecting dendrimer-based gene delivery
215(2)
4 Design criteria for formulating dendrimer vectors for gene delivery
217(1)
5 Problems in dendrimer-based gene delivery
218(1)
6 Surface modification in dendrimer for efficient gene delivery
218(5)
7 Modification of dendrimer core for efficient gene delivery
223(1)
8 Conclusion
224(1)
Acknowledgments
224(1)
References
225(6)
Further reading
231(2)
10 Dendrimers in immunotherapy and hormone therapy
233(18)
Srinivasa Reddy Bonam
Aparna Areti
Prashanth Komirishetty
Sylviane Muller
1 Dendrimers in immunotherapy
233(7)
2 Dendrimers in hormone therapy
240(2)
3 Limitations of dendrimers
242(1)
4 Future prospects
243(1)
Acknowledgments
244(1)
References
244(7)
11 Toxicity and biocompatibility aspects of dendrimers
251(24)
Avinash Gothwal
Sarita Malik
Umesh Gupta
Narenda Kumar Jain
1 Introduction
251(1)
2 Dendrimer architecture
252(1)
3 Dendrimer types
253(7)
4 Mechanism of dendrimer biocompatibility and toxicity
260(1)
5 Why are dendrimers toxic?
261(2)
6 Dendrimer toxicity and biocompatible strategies
263(2)
7 Surface modified dendrimer for compatibility
265(3)
8 Miscellaneous
268(1)
9 Future prospectus
269(1)
References
269(6)
12 Therapeutic dendrimers
275(14)
Abhay Chauhan
Dominika Krynicka
Mayank K. Singh
1 Introduction
275(1)
2 Classification of therapeutic dendrimer
276(9)
3 Conclusion
285(1)
Acknowledgments
285(1)
References
285(4)
SECTION C Dendrimers for non-pharmaceutical applications
289(46)
13 Dendrimers for diagnostic applications
291(34)
Divya Bharti Rai
Nitin Gupta
Deep Pooja
Hitesh Kulhari
1 Introduction
291(2)
2 Problem with carrier free in-vivo delivery of diagnostic agents
293(1)
3 Advantage of dendrimer-based imaging systems
293(1)
4 Design criteria for formulating dendrimer vectors as contrasting agents
293(3)
5 Dendrimer for encapsulating contrasting agents within the cavity
296(12)
6 Dendrimer for conjugating contrasting agents on the surface
308(5)
7 Major challenges of dendrimer-based diagnostic systems
313(1)
8 Conclusion
314(1)
References
314(11)
14 Dendrimer-based marketed formulations and miscellaneous applications in cosmetics, veterinary, and agriculture
325(10)
Abhay Chauhan
Chaitrali Patil
Poonam Jain
Hitesh Kulhari
1 Current scenario: Translation of dendrimer-based product from research to market
325(2)
2 Dendrimer-based formulations under clinical trial
327(1)
3 Miscellaneous applications of dendrimers
328(3)
4 Conclusion
331(1)
References
331(4)
Index 335
Abhay Singh Chauhan is Associate Professor, School of Pharmacy at the Medical College of Wisconsin, USA. He was previously Director of Pharmaceutical Nanotechnology at Concordia University, USA. His research is in the area of nanopharmaceuticals. Dr. Hitesh Kulhari is an Assistant Professor at the School of Nano Sciences, Central University of Gujarat, India. He completed his PhD at RMIT University, Australia, from 2011 to 2015. Prior to that, he earned his Master of Pharmacy at the Bundelkhand University, India, in 2008.

Dr. Kulhari's remarkable contributions have been recognized with prestigious awards, including the Prof CNR Rao Research Excellence Award in Material Science, the INSPIRE Faculty Award, and the Early Career Research Award. His research interests include nanomedicines and nanobiomaterials.
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