Pharmaceutical Biotechnology in Drug Development summarizes key concepts and the latest developments of biotechnology applied to the development of biopharmaceuticals. Chapters present a comprehensive collection of introductory biotechnology technologies and their modern concepts and cover pharmacokinetic and pharmacodynamic behavior of biopharmaceuticals and modification techniques of amino acids and nucleic acid. Other sections focus on topics such as gene therapy, immunological preparations and nanoparticles which are the major contributions of pharmaceutical biotechnology. Final chapters discuss emerging techniques in the field of pharmaceutical biotechnology to meet current patient and health care demand.
This book is an essential reference useful for pharmaceutical scientists, clinicians and academic researchers who want easy access to up-to-date practices of pharmaceutical biotechnology. Corporate researchers will also benefit from this books succinct and objective content structure.
- Includes key concepts at the foundation of the technology and relevant for protein therapeutics
- Explains how advances in other areas such as genomics, proteomics and high-throughput screening have paved the way for exploring new avenues of drug discovery
- Covers the importance of biotechnology in the development of new biopharmaceuticals, along with their pharmacodynamics and pharmacokinetics
Recenzijas
*4 stars* a methodical approach, first describing different areas of biotechnology, pharmacokinetics and pharmacodynamics, and drug targets, followed by new biological targets. [ D]efines difficult terminology before delving into further detail on the topics[ while] visuals are easy to understand and follow. [ A] very good reference and an easy read,the book offers background information necessary to understand concepts pertinent to biotechnology in drug development, then successfully takes readers through the various drug classes and medications that utilize biotechnology. [ C]lear and well written, discusses important topics very thoroughly, [ and] provides a good overview and description of each field. --©Doodys Review Service, 2023, Nur Kazzaz, PharmD (Temple University Hospital)
1. Introduction to modern concepts in pharmaceutical biotechnology and drug development
2. Pharmacokinetic and pharmacodynamics of biotechnology products
3. Role of biotechnology in amino acids modification
4. Role of biotechnology in nucleic acid modification
5. Monoclonal antibodies: Development, characterization and therapeutic application
6. Development of nanoparticles: recent developments and future prospects
7. Production of biopharmaceuticals from genetically modified organisms
8. Metabolomics as bioanalytical approach for pharmaceutical biotechnology in drug development
9. New biological targets for drug discovery and development
10. Signaling pathways of membrane-spanning receptors for drug discovery and development
Dr. Akash is currently working as an Associate Professor at the Department of Pharmaceutical Chemistry, Government College University Faisalabad, Pakistan. He got his PhD degree in Pharmaceutical Analysis from Zhejiang University, China. Currently, he is focusing on investigating the effect of endocrine disrupting chemicals on various molecular and metabolic pathways that are involved in metabolic disorders and their treatment strategies. His research work is cutting-edge and worthy of extension in developing countries, like Pakistan, where it can be most beneficial and cost-effective, especially for diabetic patients. Based on his significant scientific contributions in the field of Pharmaceutical Sciences, he has been awarded Research Productivity Awards from the Pakistan Council for Science and Technology, the PAS Gold Medal from the Pakistan Academy of Sciences, and the A.R. Shakoori Gold Medal from the Zoological Society of Pakistan. Dr. Kanwal Rehman is working as an Associate Professor at the Department of Pharmacy in The Women University, Multan, Pakistan. Dr. Rehman received her PhD in Pharmacology from Zhejiang University, China. She nurtures a keen interest in the pathogenesis of metabolic disorders and new therapeutic modalities for its treatment. Currently, she is focusing on the investigation of the role of pharmacogenomics based upon gene polymorphism on various molecular and metabolic pathways that are involved in mitogenic disorders and treatment strategies, like natural biogenic compounds against different risk factors of metabolic disorders, including pancreatitis, cardiometabolic disorders, and hormonal imbalance. Dr. Rehman has also been awarded the Research Productivity Award by the Pakistan Council for Science and Technology, Pakistan; the PAS Gold Medal from the Pakistan Academy of Sciences; and the A.R. Shakoori Gold Medal from the Zoological Society of Pakistan. Dr. Kanwal Irshad is working as PhD scholar at Department of Pharmaceutical Chemistry in Government College University Faisalabad, Pakistan. She has done her MPhil from Government College University Faisalabad, Pakistan. She completed her bachelors (Doctor of Pharmacy) from University of Agriculture, Faisalabad. She has done excellent work on exploring the effect of arsenic on hepatoxicity and nephrotoxicity and their amelioration by bioactive compounds. She has published 5 articles and 8 book chapters with international book publishers. She has received HEC PhD indigenous scholarship for completion of PhD by Higher Education Commission (HEC) of Pakistan. Currently, she is focusing on the investigation of different molecular pathways of arsenic in neurological disorders and their treatment strategies by naturally occurring bioactive compounds. Professor Chen was graduated from Zhejiang Medical University in 1983, got his Ph.D. degree in Zhejiang University and had his post-doctor training in Cornell University USA. Professor Chen now is a professor of Zhejiang University, head of the Precision Medicine & Biopharmaceuticals Laboratory, director of International Center for Precision Medicine, Zhejiang-California International NanoSystems Institute, standing committee member of the Division of Pharmacogenomics of the Chinese Pharmacological Society, committee member of the Division of Biochemical and Biotechnological Drugs of the Chinese Pharmaceutical Association, honorary chairman of the Biochemical Drugs Professional Committee of Zhejiang Pharmaceutical Association, director of Zhejiang Bioengineering Society, deputy editor-in-chief of Chinese Journal of Biochemical Pharmacy, editor of Chinese Journal of Pharmaceutical Sciences, international editor of Medical Science Monitor. Dr. Shuqing Chen published 269 articles including Cell, Advanced Materials, Biomaterials, SMALL, Clinical Cancer Research of which 148 are included in SCI/EI. He is the chief editor or editor of 16 books and textbooks. He has presided over five National Natural Science Foundation of China (including two of theStateKeyProgram), two major sub-projects of the NationalMajorScientificandTechnologicalSpecialProjectforSignificant NewDrugsDevelopment, and one key project of the National Key R & D Plan Precision Medical Research. Dr. Shuqing Chen has chaired and accomplished three scientific research, got one Second Prize award and two Third Prize award of Science & Technology Progress of Zhejiang Province.
