Klientu atbalsts: 27018494

E-grāmata: Pharmacology: Principles and Practice

3.75/5 (6 ratings by Goodreads)

Miles Hacker (The University of Toledo College of Pharmacy, Ohio, USA), Kenneth A. Bachmann (The University of Toledo College of Pharmacy, Ohio, USA), William S. Messer (The University of Toledo College of Pharmacy, Ohio, USA)

Formāts: EPUB+DRM
Izdošanas datums: 19-Jun-2009
Izdevniecība: Academic Press Inc
Valoda: eng
ISBN-13: 9780080919225

Citas grāmatas par šo tēmu:

Pharmacology

Formāts - EPUB+DRM
Cena: 67,80 €*
* ši ir gala cena, t.i., netiek piemērotas nekādas papildus atlaides
Ielikt grozā
Pievienot vēlmju sarakstam
Šī e-grāmata paredzēta tikai personīgai lietošanai. E-grāmatas nav iespējams atgriezt un nauda par iegādātajām e-grāmatām netiek atmaksāta.

Formāts: EPUB+DRM
Izdošanas datums: 19-Jun-2009
Izdevniecība: Academic Press Inc
Valoda: eng
ISBN-13: 9780080919225

Citas grāmatas par šo tēmu:

Pharmacology

DRM restrictions

Kopēšana (kopēt/ievietot):

nav atļauts
Drukāšana:

nav atļauts
Lietošana:

Digitālo tiesību pārvaldība (Digital Rights Management (DRM))
Izdevējs ir piegādājis šo grāmatu šifrētā veidā, kas nozīmē, ka jums ir jāinstalē bezmaksas programmatūra, lai to atbloķētu un lasītu. Lai lasītu šo e-grāmatu, jums ir jāizveido Adobe ID. Vairāk informācijas šeit. E-grāmatu var lasīt un lejupielādēt līdz 6 ierīcēm (vienam lietotājam ar vienu un to pašu Adobe ID).

Nepieciešamā programmatūra
Lai lasītu šo e-grāmatu mobilajā ierīcē (tālrunī vai planšetdatorā), jums būs jāinstalē šī bezmaksas lietotne: PocketBook Reader (iOS / Android)

Lai lejupielādētu un lasītu šo e-grāmatu datorā vai Mac datorā, jums ir nepieciešamid Adobe Digital Editions (šī ir bezmaksas lietotne, kas īpaši izstrādāta e-grāmatām. Tā nav tas pats, kas Adobe Reader, kas, iespējams, jau ir jūsu datorā.)

Jūs nevarat lasīt šo e-grāmatu, izmantojot Amazon Kindle.

This unique and much needed textbook meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker, et al. to help train new drug researchers.

The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, Pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process.

*Uses individual drugs to explain molecular actions
*Full color art program explains molecular and chemical concepts graphically
*Logical structure reflecting the current state of pharmacology and translational research, starting with receptors and finishing with target molecules
*Covers such intricacies as drug resistance and cell death
*Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool

This unique and much needed textbook meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker, et al. to help train new drug researchers.

The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, Pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process.

*Uses individual drugs to explain molecular actions
*Full color art program explains molecular and chemical concepts graphically
*Logical structure reflecting the current state of pharmacology and translational research
*Covers such intricacies as drug resistance and cell death
*Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool

Papildus informācija

Only textbook of its kind to emphasize the science behind pharmacology rather than its clinical or therapeutic applications

Contributors

Preface

History of Pharmacology---From Antiquity to the Twentieth Century

(8)

What Is Pharmacology?

(1)

What Is the Position of Pharmacology in the Field of Therapeutics?

(1)

The Beginnings of Pharmacology

(1)

Pharmacology of the Greco-Roman Era

(1)

Pharmacology and the Middle Ages

(1)

Pharmacology and the Renaissance

(1)

Pharmacology and the Baroque Period

(1)

The Birth of Modern Pharmacology

(4)

Dosage Forms and Their Routes of Administration

(22)

Introduction

(1)

Therapeutic Ramifications in Selecting the Appropriate Dosages Forms

(4)

Routes of Drug Administration

(17)

Membranes and Drug Action

(12)

Introduction

(1)

What Is a Membrane?

(13)

Membranes Environment

(2)

The Role of Drug Polarity

(2)

Crossing the Membrane

(3)

The Membrane as a Drug Target

(4)

Drug Transporters

(1)

Key Points and Conclusion

Ligand-Receptor Binding and Tissue Response

(32)

Introduction

(1)

Dose-Response Curves

(1)

Receptors

(1)

Affinity

(1)

Efficacy

(3)

Antagonism

(4)

Constitutive Receptor Activity

(1)

Extended Ternary Complex Model

(1)

Conclusions

(2)

Hormesis and Pharmacology

(28)

Introduction

(6)

Hormesis

(12)

Selected Issues

(2)

Adaptive Response, Preconditioning and Autoprotection: How These Concepts Relate to Hormesis

(1)

Implementing Hormesis into Pharmacology and Toxicology

(3)

Remaining Issues

(1)

Summary and Conclusion

(4)

Signal Transduction and Second Messengers

103

(10)

Receptor Communication

103

(7)

Receptor/Second Messenger Crosstalk

110

(1)

Signal Transduction Targets for Drug Discovery

111

(2)

Drug Distribution

113

(18)

Introduction

113

(1)

Biological Membranes

114

(8)

Factos Influencing Drug Distribution

122

(2)

Pharmacokinetic/Pharmacodynamic Distribution Properties

124

(1)

Specific Tissue Barriers

125

(2)

Summary

127

(4)

Drug Metabolism

131

(44)

Introduction

131

(6)

Drug-Metabolizing Enzymes

137

(31)

Conclusions and Key Points

168

(7)

Drug Excretion

175

(26)

Introduction

175

(1)

Overview of Membrane Transporter Involved in Drug Excretion

176

(5)

Renal Drug Excretion

181

(13)

Other Routes of Drug Excretion

194

(2)

Drug Excretion: Issues to Consider

196

(1)

Conclusions and Future Perspectives

197

(4)

Pharmacokinetic Modeling

201

(78)

Introduction

202

(4)

Chemical Transport

206

(5)

Absorption

211

(2)

Distribution

213

(3)

Elimination (Metabolism and Excretion)

216

(4)

Organization of Single-Dose Pharmacokinetic Model Information

220

(1)

One Compartment Bolus IV Injection (Instantaneous Absorption) Model

221

(6)

One Compartment IV Infusion (Zero-Order Absorption) Model

227

(6)

One Compartment First-Order Absorption Model

233

(7)

Two Compartment Bolus IV Injection (Instantaneous Absorption) Model

240

(8)

Two Compartment IV Infusion (Zero-Order Absorption) Model

248

(5)

Two Compartment First-Order Absorption Model

253

(7)

Generalized Multicompartment Models

260

(4)

Multiple Dosing Models

264

(7)

Advanced Pharmacokinetic Modeling Topics

271

(5)

Summary of Key Points

276

(3)

Bioanalytical Tools for Drug Analysis

279

(24)

Introduction

279

(1)

Small Molecule Chemical Bioanalysis

280

(4)

Theoretical Fundamentals of Chromatography

284

(6)

Analytical Separations in Practice

290

(11)

Key Points and Conclusions

301

(2)

Drug-Drug Interactions with an Emphasis on Drug Metabolism and Transport

303

(24)

Introduction

303

(4)

DDIs Associated with Altered Drug Metabolism

307

(10)

Drug Transporters and DDIs

317

(3)

DDIs Associated with Protein Binding

320

(4)

Conclusions and Key Points

324

(3)

Adverse Drug Reactions

327

(26)

Introduction

327

(1)

Type A ADRs

327

(4)

Examples of Type A ADRs

331

(1)

Avoiding Type A ADRs

332

(1)

Pharmacovigilance and ADR

333

(1)

Type B ADRs

334

(15)

Summary

349

(4)

Risk Assessment

353

(18)

History

353

(1)

Hazard Identification

354

(1)

Dose Response Assessment

355

(1)

Exposure Assessment

356

(1)

Risk Characterization

357

(7)

Radiological Risk Assessments

364

(1)

Risk Management

365

(2)

Risk Communication

367

(4)

Drug Resistance

371

(16)

Introduction

371

(1)

Cancer Cell Drug Resistance

371

(8)

Drug Resistance in Infectious Diseases

379

(6)

Summary

385

(2)

Ion Channels

387

(42)

Introduction

387

(4)

Ion Channel Structure and Function: Basic Principles and Mechanisms

391

(5)

Ion Channel Pharmacology: Principles and Mechanisms

396

(2)

Ion Channel Groups: Functional Implications and Pharmacological Modulators

398

(16)

Methods for the study of ion channels

414

(6)

Ion Channels and Disease

420

(1)

Ion Channels as Drug Targets

421

(3)

Key Points and Conclusions

424

(5)

Targeting the Cell Cycle to Kill Cancer Cells

429

(26)

Introduction

429

(1)

Introduction

429

(1)

The Cell Cycle

430

(2)

Cell Cycle Checkpoints

432

(10)

Mitotic Kinases as targets of New Chemotherapeutics

442

(5)

Conclusions

447

(8)

Programmed Cell Death

455

(20)

Introduction

455

(1)

Mechanism and Regulation of PCD

456

(9)

Apoptosis in Health and Disease

465

(2)

Therapeutic Strategies for Targeting Apoptosis

467

(6)

Key Points and Conclusions

473

(2)

Drug Discovery

475

(86)

Introduction

475

(10)

Underlying Principles

485

(47)

Drug Discovery Case Studies

532

(22)

Summary

554

(7)

Genomics and Proteomics in Drug Design and Discovery

561

(14)

Introduction

561

(1)

Genomics and Proteomics

561

(2)

Major Technological Platforms of Genomics and Proteomics

563

(2)

Current Achievements and Potential Application of Genomics and Proteomics in Drug Design and Discovery

565

(4)

Conclusion and Future Prospects

569

(6)

The Future of Pharmacology

575

(6)

Introduction

575

(1)

The Problem

575

(1)

Strategies for Searching for Future Drugs

576

(1)

Tools for Searching for Future Drugs

577

(1)

The Drugs of the Future

578

(3)

Index

581

Biežāk uzdotie jautājumi par e-grāmatām

Permanent link: https://www.kriso.lv/db/97800809192256e.html

Keywords:

Pharmacology

E-grāmata: Pharmacology: Principles and Practice

DRM restrictions

Kopēšana (kopēt/ievietot):

Drukāšana:

Lietošana:

Papildus informācija

Konts un iestatījumi

Meklēšana

Meklēt datubāzē

Refine By

Tēmas Ebook Subjects

Izvēlieties iepirkumu grozu