Phospholipases in Physiology and Pathology is a thorough, comprehensive overview of the mechanistic and therapeutic aspects of phospholipases. The seven-volume set considers an elegant approach to unravelling the potential biochemical and molecular mechanisms of phospholipases in health and diseases. Additionally, the book discusses the use of phospholipases and their metabolites, and their downstream signaling components, as therapeutic targets for establishing prevention strategies. Volume 4, Role of Phospholipases in Inflammation, Gene Expression, and Apoptosis, covers the role of phospholipases in inflammation and apoptosis. In addition, some chapters have been included that relate to the implications of phospholipases in gene expression, noncoding RNAs, and epigenetic mechanisms in diseases such as neuronal conditions, atherosclerosis, and several types of cancers.
A. Implication in Inflammation
1. Role and Regulation of Phospholipase D2 in inflammatory diseases
2.
Cytosolic Phospholipase A2 (PLA2G4) mediated oxidative and inflammatory
responses in neurodegenerative diseases
3. Modulation of Phospholipases by Phenolic Compounds: Novel Targets in the
Management of Inflammatory Diseases
4. Phospholipase A2 superfamily and their role in chronic inflammatory
conditions with relation to adjuster cells
5. Role of
N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) in
neuroinflammation and neurodegeneration
6. Role role of phospholipase A2 in vascular health and disease
7.
Phospholipase A2 as modulator of inflammation
8. Inflammatory Effects of
Phospholipases A2 Present in Snake Venom of the Genus Bothrops
9. Lipoprotein-associated phospholipase A2: Antioxidant and inflammatory
roles
10. Phospholipases and membrane remodeling in inflammation and neoplasia
11. Phospholipase A2 mediated regulation of inflammation and apoptosis
B. Implication in Apoptosis
12. Role of platelet-activating factor
acetylhydrolase on the inflammatory and apoptotic processes in
atherosclerosis
13. Functional role of phospholipase D in apoptosis and
cancer
14. Role of cytosolic phospholipase A2 in TNF-a and caspase-mediated
apoptosis
15. Phospholipases: Insights into the potential role of cell death
16. Calcium- dependent and independent phospholipases and apoptosis
C. Implication in Gene Expression and Non-coding RNAs
17. Influence of phospholipase on expression of metallothionein to repair
cells
18. Epigenetic tools of phospholipase A1 and A2 in gene therapy
19. Role
of non-coding RNAs phospholipases mediated diseases
20. The genetics of Phospholipase induced redox signaling in
neuroinflammation and neuronal diseases
21. Signal transduction and regulation of phospholipases during tumorigenic
processes
22. Functions and gene expression alterations of phospholipase C in gemetes
23. Highlighting the role of phospholipase A2 and non-coding RNA in
colorectal cancer
24. Long non-coding RNAs: a new frontier of ameliorative potentiality on
cytosolic phospholipase A2 (cPLA2) mediated non- alcoholic fatty liver
disease
25. Crosstalk between Phospholipases and non-coding RNAs in cancer
26. Relationship between Phospholipases and lncRNAs during the onset of
diseases
27. Epigenetic signatures in phospholipase receptor genes
predict cancer initiation and therapeutic progression
Dr. Sajal Chakraborti, PhD, DSc is a Professor at the Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India. He did post-doctoral research at the Johns Hopkins Medical Institution, Baltimore; New York Medical College, New York; the University of Utah Health Sciences Center, Salt Lake City, Utah; and the University of Florida, Gainesville, Florida. He has over 35 years teaching and independent research experience in Biochemistry, Molecular Physiology and Cell Biology. He has published over 110 original research articles, 25 review articles and book chapters, and also edited twelve books published by Springer.
